Modern Pathology - FIGURE 3 for article: Fusion, Disruption, and Expression of HMGA2 in Bone and Soft Tissue Chondromas

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Fusion, Disruption, and Expression of HMGA2 in Bone and Soft Tissue Chondromas

Anna Dahlén, Fredrik Mertens, Anders Rydholm, Otte Brosjö, Johan Wejde, Nils Mandahl and Ioannis Panagopoulos

FIGURE 3.

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Metaphase FISH of Case 1 with an intragenic rearrangement of HMGA2. The cosmids probes 142H1 (green) and 27E12 (red) hybridize to exons 1–2 and exons 4–5 of HMGA2, respectively. A, normal metaphase. B, metaphase with an ins(4;12), in which the signal of 142H1 is seen on der(12) and the signal of 27E12, on der(4).

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