Modern Pathology

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The Role of CD10 Staining in Distinguishing Invasive Endometrial Adenocarcinoma from Adenocarcinoma Involving Adenomyosis

Alessandra F Nascimento, Michelle S Hirsch, Aida Cviko, Bradley J Quade and Marisa R Nucci

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FIGURE 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

FIGURE 1.

A, B, invasive endometrial adenocarcinoma (H&E stain). C, lack of CD10 staining around the neoplastic glands. Intraluminal and stromal granulocytes are an internal positive control.

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FIGURE 2.

A, invasive adenocarcinoma with accompanying desmoplastic reaction (H&E stain). B, CD10-expressing cells are present immediately adjacent to the invasive focus.

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FIGURE 3.

A, invasive endometrial adenocarcinoma (H&E stain). B, focal desmin-expressing cells are present immediately adjacent to the invasive glands (myometrium as internal positive control); these cells also expressed CD10.

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FIGURE 4.

A, partial replacement of adenomyotic focus by endometrial adenocarcinoma without myometrial invasion (H&E stain). B, the stromal cells of the adenomyotic focus are positive for CD10.

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FIGURE 5 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

FIGURE 5.

A, B, endometrial adenocarcinoma with involvement of adenomyosis and coexistent myometrial invasion. Focus of adenomyosis involved by endometrial adenocarcinoma (on left) and focus of invasive tumor (on right). C, CD10 is positive in the stromal cells in the adenomyotic focus but absent in cells surrounding the invasive focus.

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