Modern Pathology

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Expression of CD10 in Malignant Müllerian Mixed Tumors and Adenosarcomas: An Immunohistochemical Study

Yoshiki Mikami, Sakae Hata, Takako Kiyokawa and Toshiaki Manabe

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FIGURE 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

FIGURE 1.

Malignant müllerian mixed tumor, consisting of a mixture of carcinomatous and sarcomatous components with an island of cartilage (A). Immunohistochemistry for CD10, showing diffuse and strong staining of sarcomatous components (B).

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FIGURE 2.

Malignant müllerian mixed tumor, showing distinct cytoplasmic staining for CD10 in the sarcomatous components.

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FIGURE 3.

Rhabdomyoblastic cells in malignant müllerian mixed tumor, with abundant eosinophilic and filamentous cytoplasm scattered in the sarcomatous components (A), which are positive for myoglobin (B) and CD10 (C).

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FIGURE 4.

Carcinomatous components in malignant müllerian mixed tumor. Elements of adenocarcinoma (A) show membranous and cytoplasmic staining for CD10 (B). Portions of undifferentiated carcinoma (C) also contain cells positive for CD10 (D).

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FIGURE 5.

Müllerian adenosarcoma, characterized by a mixture of benign-appearing müllerian-type epithelium and sarcomatous components consisting of spindle-shaped cells (A). Hypercellular areas accentuated by strong CD10 expression are arranged in a concentric fashion around dilated glands (B).

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FIGURE 6.

High-grade leiomyosarcoma characterized by pleomorphic nuclear morphology and increased mitotic figures (A). Neoplastic cells show cytoplasmic immunoreactivity for CD10 (B).

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