FIGURES AND TABLES
FROM:
Kupffer Cell Aggregation and Perivenular Distribution in Steatohepatitis
Jay H Lefkowitch, Jennifer H Haythe and Nicole Regent
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FIGURE 1.
CD68 immunostaining of Kupffer cells in a case of mild steatohepatitis. A, low magnification shows prominent aggregated Kupffer cells near the central veins (arrows; magnification, 50 
). B, a portion of A shows a portal tract (P) and aggregated prominent Kupffer cells near the central vein (arrow). Individual elongated Kupffer cells in the midzonal and periportal regions are less conspicuous (magnification, 125 ). C, aggregated Kupffer cells with enlarged, rounded cell bodies and intracytoplasmic granules are present near mildly ballooned hepatocytes and the central vein (V; magnification, 325 ).
FIGURE 2.
CD68 immunostaining of normal control liver shows individual elongated Kupffer cells diffusely within the sinusoids. (V = central vein; magnification, 125 .) Inset, individual, elongated, tapering Kupffer cells are present within sinusoids (magnification, 325 ).
FIGURE 3.
A and B are consecutive serial sections from a case of severe NASH. A, the centrilobular region at center right shows markedly ballooned hepatocytes, many of which contain Mallory bodies (short arrows). Sinusoidal inflammation at Points 1, 2, and 3 correspond in B to prominent aggregates of Kupffer cells. A large lipid droplet at top appears to be within a hepatocyte (open arrow). Hematoxylin and eosin stain, 325 . B, CD68-immunostained serial section demonstrates Kupffer cells aggregates within sinusoids. A large vacuole of lipid at top is enclosed within a Kupffer cell (open arrow; specific immunoperoxidase; magnification, 325 .)
FIGURE 4.
Mild (A) and marked (B) fatty liver with CD68 immunostaining for Kupffer cells. A diffuse sinusoidal distribution of individual Kupffer cells is present, without perivenular aggregation. V = central vein. An enlarged Kupffer cell is seen near the bottom in B. (Magnification, A and B, 125 .)
