Modern Pathology - FIGURE 3 for article: Kupffer Cell Aggregation and Perivenular Distribution in Steatohepatitis

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Kupffer Cell Aggregation and Perivenular Distribution in Steatohepatitis

Jay H Lefkowitch, Jennifer H Haythe and Nicole Regent

FIGURE 3.

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A and B are consecutive serial sections from a case of severe NASH. A, the centrilobular region at center right shows markedly ballooned hepatocytes, many of which contain Mallory bodies (short arrows). Sinusoidal inflammation at Points 1, 2, and 3 correspond in B to prominent aggregates of Kupffer cells. A large lipid droplet at top appears to be within a hepatocyte (open arrow). Hematoxylin and eosin stain, 325 $times$ . B, CD68-immunostained serial section demonstrates Kupffer cells aggregates within sinusoids. A large vacuole of lipid at top is enclosed within a Kupffer cell (open arrow; specific immunoperoxidase; magnification, 325 $times$ .)

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