Modern Pathology

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Primary Peripheral PNET/Ewing's Sarcoma of the Dura: a Clinicopathologic Entity Distinct from Central PNET

Franceska Dedeurwaerdere, Caterina Giannini, Raf Sciot, Brian P Rubin, Giorgio Perilongo, Laura Borghi, Maria Luisa Ballotta, Erwin Cornips, Anouk Demunter, Brigitte Maes and Angelo P Dei Tos

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FIGURE 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

FIGURE 1.

MRI (T1 weighted, after Gadolinium injection): parasagittal, polylobulated mass with broad base on the dura; intense contrast enhancement is present (Case 1).

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FIGURE 2.

MRI (T1 weighted, after Gadolinum injection): a right parietal, parasagittal mass, strongly and diffusely enhancing after Gadolinum injection (Case 2). Dural "tails" are present, suggesting the preoperative diagnosis of meningioma.

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FIGURE 3.

Case 2: low power microscopic view, showing sheets of monotonous small round cells (A). High power microscopic view, highlighting an area of necrosis and several mitotic figures (B). The tumor cells display a diffuse, strong, membrane expression of CD99 (C). FISH with EWS centromere/EWS telomere probe set of Case 2. Split signals indicate EWS region rearrangement (D).

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FIGURE 4.

Result of the RT-PCR for the detection of the EWS/FLI1 fusion transcript in Case 1. Lane M: molecular marker; Lane 1: positive control; Lane 2: patient's sample; Lane 3: negative control.

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TABLE 1 - Summary of Clinical Data and Follow-Up of Present and Previously Reported Cases - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

TABLE 1 - Summary of Clinical Data and Follow-Up of Present and Previously Reported Cases.

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TABLE 2 - Summary of Pathologic and Molecular Data of Present and Previously Reported Cases - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, please contact help@nature.com or the author

TABLE 2 - Summary of Pathologic and Molecular Data of Present and Previously Reported Cases.

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