Modern Pathology - FIGURE 1 for article: c-kit Mutations in Gastrointestinal Stromal Tumors Occur Preferentially in the Spindle Rather Than in the Epithelioid Cell Variant

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c-kit Mutations in Gastrointestinal Stromal Tumors Occur Preferentially in the Spindle Rather Than in the Epithelioid Cell Variant

Eva Wardelmann, Iris Neidt, Erhard Bierhoff, Nicola Speidel, Christoph Manegold, Hans-Peter Fischer, Ulrich Pfeifer and Torsten Pietsch

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FIGURE 1.

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A–H, morphological and immunohistochemical features of a spindle cell (A, C, E, G) and an epithelioid (B, D, F, H) gastrointestinal stromal tumor. A, the spindle cells are arranged in storiform and herringbone patterns and have blunt-ended nuclei. B, the epithelioid cells are arranged in organoid clusters and have round nuclei and abundant cytoplasm. Both subtypes express CD34 (C and D), bcl-2 (E and F), and the Kit receptor (G and H). Magnifications, 240 $times$ .

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