Modern Pathology

FIGURE 1

FROM:

ETV6 Rearrangements in Patients with Infantile Fibrosarcomas and Congenital Mesoblastic Nephromas by Fluorescence In Situ Hybridization

Camilo Adem, David Gisselsson, Paola Dal Cin and Antonio G Nascimento

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FIGURE 1.

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A, ideogram of a G-banded chromosome 12 with positions of the ETV6 and KRAS2 probes. B, schematic description of hybridization pattern resulting from a 12;15 translocation involving the ETV6 gene region: the ETV6 signal (green) is split between the derivative (der) chromosomes 12 and 15, whereas the KRAS2 signal remains on the der(12). C, schematic interphase pattern in nuclei without and with rearrangement of the ETV6 region. D, interphase nucleus with a normal hybridization pattern; in other words, two pairs of colocalized ETV6 (green) and KRAS2 (red) signals; blending of red and green results in yellow fluorescence. E, nucleus from Case 3, showing two copies of the KRAS2 region (red) and three signals for the ETV6 region; the smaller green signal is located some distance from the red-green-yellow signals, indicating that it is translocated to another chromosome. F, nucleus from Case 7, showing one intact and one split signal for ETV6 (red) and three signals for the centromere of chromosome 11 (green).

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