Modern Pathology

TABLE 2

FROM:

Extracutaneous Angiosarcomas Metastatic to the Lungs: Clinical and Pathologic Features of Twenty-One Cases

T Bocklage, K Leslie, S Yousem and T Colby

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TABLE 2. Histologic and Immunohistochemical Features of 22 Cases of Angiosarcoma Metastatic to the Lungs

Figure and tables index
CaseVasoformative AreasCell TypeNuclear GradeImmunohistochemical Staining
1NoSpindle1 and 2VonWF+
2YesSpindle1 and 2VonWF, CD31, CD34+; Ker-
3YesSpindle and epithelioid1 and 2N/P
4YesSpindle2VonWF+; Ker-
5NoSpindle and epithelioid2 and 3N/P
6YesSpindle and epithelioid3VonWF+; Ker-
7NoSpindle and epithelioid2 and 3VonWF+
8NoSpindle2N/P
9YesSpindle2VonWF+; Ker-
10NoSpindle2VonWF+ and ulex lectin+
11YesEpithelioid3VonWF, Cam5.2, and AE1/AE3 Ker, +
12YesSpindle2VonWF+; Ker-
13YesSpindle2VonWF+, Ker-
14YesSpindle1 and 2N/P
15YesSpindle and epithelioid3VonWF, ulex lectin, and AE1/AE3 Ker, +
16NoSpindle and epithelioid2N/P
17YesSpindle and epithelioid2VonWF, CD31, and CD34, +; Ker-
18YesSpindle and epithelioid3VonWF-, Ker-Only Vim+
19YesEpithelioid3VonWF+
20YesSpindle and epithelioid1 and 2N/P
21YesSpindle and epithelioid2 and 3N/P

 Nuclear grade 1 = uniform nuclei with minimal nuclear shape variation, inconspicuous nucleoli; nuclear grade 2 = moderate variation in nuclear shape and size; Nuclear Grade 3 = marked pleomorphism and/or vesicular nuclei with macronucleoli and/or irregular chromatin clumping. VonWF, Von Willebrand Factor; Ker, Keratin; N/P, not performed; AE1/AE3, AE1/AE3 keratins; VIM, vimentin.

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