Case Report
Mod Pathol 2001;14(11):1183–1186
Metaplastic Carcinoma of the Breast: p53 Analysis Identified the Same Point Mutation in the Three Histologic Components
Xiaojuan Wang M.D.1, Ichiro Mori M.D., Ph.D.1, Weihua Tang M.D.1, Qifeng Yang M.D.2, Misa Nakamura Ph.D.1, Yasushi Nakamura M.D., Ph.D.1, Misako Sato B.S.1, Takeo Sakurai M.D., Ph.D.2 and Kakudo Kennichi M.D., Ph.D.1
- 1Department of Pathology, Wakayama Medical University, Japan
- 2Department of Surgery, Affiliated Kihoku Hospital, Wakayama Medical University, Japan
Correspondence: Xiaojuan Wang, M.D., Department of Pathology, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Japan 641-0012; e-mail: wang-xj@mail.wakayama-med.ac.jp; fax: 81-073-446-4825.
Accepted 21 July 2001.
Abstract
A rare case of metaplastic carcinoma of the breast with both squamous metaplasia and cartilaginous metaplasia was reported. Histologically, the neoplasm revealed complex features, which were consisting of invasive ductal carcinoma, squamous carcinomatous component and chondrosarcomatoid component. Gradual transition of each component was recognized microscopically. p53 mutation analysis disclosed the same point mutation in three histologically different components, but not in the normal epithelium. Based on the morphologic findings, immunohistochemical findings and the p53 mutation analysis, we concluded that these three components in the tumor originated from the same duct progenitor cells.
Keywords:
Breast cancer, cartilaginous metaplasia, Metaplastic carcinoma, p53, Squamous metaplasia
