TABLE 6
FROM:
Liver Pathology: Cirrhosis, Hepatitis, and Primary Liver Tumors. Update and Diagnostic Problems
Linda Ferrell
BACK TO ARTICLETABLE 6. PBC and PSC
| Similarities | ||
| Disappearing bile ducts | ||
| Chronic inflammatory infiltration | ||
| Interface hepatitis ("biliary piecemeal") | ||
| Periportal Mallory bodies and copper |
| PBC | PSC | |
|---|---|---|
| Histology | ||
| Granulomas, bile duct | +++ |  |
| Granulomas, parenchymal | +++ | |
| Lymphoid aggregates | +++ | + |
| Sinusoidal infiltrate | +++ | |
| Scarring at bile duct | + | ++ |
| Concentric fibrosis | | ++ |
| Portal tracts without ducts | +++ | + |
| Lesions of LBDO | No | Yes |
| Lab/clinical | ||
| Hx of UC/Crohn's | - | ++ |
| AMA | +++ | |
| ANA, DSDNA, SMAb | + | |
 IgM | +++ | - |
| Alkaline phosphatase | ++ | ++ |
| ERCP findings | + | +++ |
| Long indolent course | + | +++ |
PBC, primary biliary cirrhosis; PSC, primary sclerosing cholangitis; LBDO, large bile duct obstruction; UC, ulcerative colitis; AMA, antimitochondrial antibody; ANA, antinuclear antibody; DSDNA, double-stranded DNA; SMAb, smooth muscle antibody; ERCP, endoscopic retrograde cholangiopancreatography; +, present to a 1+ degree; ++, present to a 2+ degree; +++, present to a 3+ degree; -, not present; , minimal degree of involvement.
From Ferrell LD. Liver and gallbladder pathology. In: Weidner N, editor. The difficult diagnosis in surgical pathology. Philadelphia: W.B. Saunders; 1996. p. 290. Reprinted with permission.
