Modern Pathology

FIGURE 4

FROM:

Synovial Sarcoma of the Upper Digestive Tract: A Report of Two Cases with Demonstration of the X;18 Translocation by Fluorescence In Situ Hybridization

Steven D Billings, Lorraine F Meisner, Oscar W Cummings and Eduardo Tejada

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FIGURE 4.

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Typical appearance of the red X and green 18 probes characterizing the diagnostic t(X;18) in four separate synovial sarcoma nuclei from the gastroesophageal tumor (A) and the gastric tumor (B). The translocation is characterized by the red and green signals touching or lying less than three centromere lengths to each other (lower left corner of A) in the interphase nuclei. The second green 18 signal is randomly located in the nuclei. The second red X signal is randomly located in the gastric tumor, but there is no second red X signal in the gastroesophageal tumor because the patient is male. This pattern is consistent with the presence of the X;18 translocation.

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