Milestones timeline

• PDF of Milestones timeline (82 KB)
• PDF of all Milestones (1,560 KB)

• 1952

  • Electrophoresis (Milestone 1)

• 1967

  • Discovery of DNA ligase (Milestone 2)

• 1969

  • FISH (Milestone 3)

• 1970

  • Discovery of restriction enzymes (Milestone 4)

  • Discovery of reverse transcriptase (Milestone 5)

• 1972

  • Cloning (Milestone 2)

• 1975

  • Southern blot (Milestone 6)

• 1977

  • 1937

    DNA sequencing (Milestone 7)

• 1980

  • RFLP concept (Milestone 8)

• 1982

  • P-element-mediated manipulation of the fly genome (Milestone 9)

  • Whole genome shotgun (Milestone 10)

• 1983

  • RFLP realization (Milestone 8)

• 1985

  • PCR (Milestone 11)

  • DNA fingerprinting (Milestone 12)

• 1987

  • YACs (Milestone 13)

  • Site-directed mutagenesis of the mouse genome (Milestone 9)

• 1988

  • ChIP (Milestone 14)

• 1990

  • BLAST — the key to comparative genomics (Milestone 15)

• 1992

  • BACs (Milestone 13)

• 1995

  • Microarray technology (Milestone 16)

• 1998

  • RNAi (Milestone 17)

  • Sequencing by synthesis (Milestone 18)

  • Full-length cDNA technologies (Milestone 5)

• 2002

  • Launch of UCSC Genome Browser (Milestone 19)

• 2003

  • DNA assembly programs (Milestone 20)

• 2004

  • ENSEMBL - an example of a gene annotation tool (Milestone 21)

• 2005

  • HapMap (Milestone 22)

  • Sequencing by ligation/polony sequencing (Milestone 18)

• 2006

  • Genome-wide maps of DNA methylation (Milestone 23)

• PDF of Milestones timeline (82 KB)
• PDF of all Milestones (1,560 KB)

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