milestones timeline

• PDF of milestones timeline (411 KB)
• PDF of all milestones (2,212 KB)

• 1942

  

  Discovery of actomyosin (milestone 1)

• 1953

  Abercrombie's studies of cell migration (milestone 2)

• 1954

  Sliding filament model for muscle contraction (milestone 3)

• 1965

  Dynein, the first microtubule-dependent motor (milestone 4)

• 1967

  

  Dynamic filaments in the mitotic spindle (milestone 5)

• 1968

  Tubulin, the binding partner of colchicine in the mitotic spindle (milestone 6)

• 1968-1978

  Identification of intermediate filaments (milestone 7)

• 1972-1977

  Actomyosin contractile ring in cytokinesis (milestone 8)

• 1973

  Isolation of the first non-conventional myosin (milestone 9)

• 1974

  Visualization of actin filaments in non-muscle cells (milestone 10)

• 1978

  

  Analysis of cytoskeletal dynamics with fluorescently labelled probes (milestone 11)

• 1980

  

  Actin-adhesion links to the extracellular matrix (milestone 12)

• 1981-1982

  Differential interference contrast microscopy (milestone 13)

• 1984

  Microtubule dynamic instability (milestone 14)

• 1985

  The microtubule molecular motor kinesin (milestone 15)

• 1989 and 1995

  

  γ-Tubulin and γ-TURC (milestone 16)

• 1989-1996

  Single-molecule assays for motor proteins (milestone 17)

• 1990-1993

  Structures of actin and myosin (milestone 18)

• 1991

  Keratins in health and disease (milestone 19)

• 1992

  

  Rho GTPases as cytoskeletal regulators (milestone 20)

• 1992-1998

  Discovery of the bacterial cytoskeleton (milestone 21)

• 1993

  Cilia and flagella formation and function (milestone 22)

• 1994-1998

  

  Isolation of the first actin nucleator (milestone 23)

• 1995-1996

  Structures of microtubules and kinesin (milestone 24)

• 1999

  

  Reconstitution of a complete motile system in vitro (milestone 25)

• PDF of milestones timeline (411 KB)
• PDF of all milestones (2,212 KB)

Main navigation

NPG resources

• Nature
• Nature Cell Biology
• Nature Reviews Molecular Cell Biology
• Nature Structural & Molecular Biology
• Cell Migration Gateway
• cancer@nature.com
• development@nature.com
• molecular cell biology@nature.com
• systems biology@nature.com
• Nature web focus. Muscle crossbridges: 50-year anniversary