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Tools and techniques

Reviews
Carpenter, A. E. & Sabatini, D. M. Systematic genome-wide screens of gene function. Nature Rev. Genet. 5, 11-22 (2004)

Dykxhoorn, D. M., Novina, C. D. & Sharp, P. A. Killing the messenger: short RNAs that silence gene expression. Nature Rev. Mol. Cell Biol. 4, 457-467 (2003)

van Roessel, P. & Brand, A. H. Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins. Nature Cell Biol. 4, E15-E20 (2002)

Heintz, N. BAC to the future: the use of BAC transgenic mice for neuroscience research. Nature Rev. Neurosci. 2, 861-870 (2001)

Mittal, V. Improving the efficiency of RNA interference in mammals. Nature Rev. Genet. 5, 355-365 (2004)

Hadjantonakis, A. -K., Dickinson, M. E., Fraser, S. E. & Papaioannou, V. E. Technicolour transgenics: imaging tools for functional genomics in the mouse. Nature Rev. Genet. 4, 613-625 (2003)

Brown, W. R. A., Hubbard, S. J., Tickle, C. & Wilson, S. A. The chicken as a model for large-scale analysis of vertebrate gene function. Nature Rev. Genet. 4, 87-98 (2003)

Schoenwolf, G. Cutting, pasting and painting: experimental embryology and neural development. Nature Rev. Neurosci. 2, 763-771 (2001)

Weaver, M & Hogan, B. Powerful ideas driven by simple tools: lessons from experimental embryology. Nature Cell Biol. 3, E165-E167 (2001)

Innovation
Shav-Tal, Y., Singer, R. H. & Darzacq, X. Imaging gene expression in single living cells. Nature Rev. Mol. Cell Biol. 5, 855-862 (2004)

Hunter, P. J. & Borg, T. K. Integration from proteins to organs: the Physiome Project. Nature Rev. Mol. Cell Biol. 4, 237-243 (2003)

Research papers
Yen, L., Svendsen, J., Lee, J.-S., Gray, J. T., Magnier, M., Baba, T., D'Amato, R. J. & Mulligan, R. C. Exogenous control of mammalian gene expression through modulation of RNA self-cleavage. Nature 431, 471-476 (2004)

News and Views
Eggleston, A. K. Biological techniques: Tailor-made riboswitches. Nature 431, 409 (2004)

Famulok, M. Chemical biology: Green fluorescent RNA. Nature 430, 976-977 (2004)

Novina, C. D. & Sharp, P. A. The RNAi revolution. Nature 430, 161-164 (2004)


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