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Establishment of germ layers and body axes

Reviews
Chisholm, R. L. & Firtel, R. A. Insights into morphogenesis from a simple developmental system. Nature Rev. Mol. Cell Biol. 5, 531-541 (2004)

G�mez-Skarmeta, J. L., Campuzano, S. & Modolell, J. Half a century of neural prepatterning: the story of a few bristles and many genes. Nature Rev. Neurosci. 4, 587-598 (2003)

Gonz�lez-Gait�n, M. Signal dispersal and transduction through the endocytic pathway. Nature Rev. Mol. Cell Biol. 4, 213-224 (2003)

Caspary, T. & Anderson, K. V. Patterning cell types in the dorsal spinal cord: what the mouse mutants say. Nature Rev. Neurosci. 4, 290-298 (2003)

Rallu, M., Corbin, J. G. & Fishell, G. Parsing the prosencephalon. Nature Rev. Neurosci. 3, 943-951 (2002)

Maden, M. Retinoid signalling in the development of the central nervous system. Nature Rev. Neurosci. 3, 843-853 (2002)

Opinion
Chizhikov, V. V. & Millen, K. J. Mechanisms of roof plate formation in the vertebrate CNS. Nature Rev. Neurosci. 5, 808-812 (2004)

Martinez Arias, A. Wnts as morphogens? The view from the wing of Drosophila. Nature Rev. Mol. Cell Biol. 4, 321-325 (2004)

Bienz, M. & Clevers, H. Armadillo/β-catenin signals in the nucleus — proof beyond a reasonable doubt? Nature Cell Biol. 5, 179-182 (2003)

Gilbert, S. F. Opening Darwin's black box: teaching evolution through developmental genetics. Nature Rev. Genet. 4, 735-741 (2003)

Research papers
Rajagopalan, S., Deitinghoff, L., Davis, D., Conrad, S., Skutella, T., Chedotal, A., Mueller, B. K. & Strittmatter, S. M. Neogenin mediates the action of repulsive guidance molecule. Nature Cel Biol. 6, 756-762 (2004)

Reber, M., Burrola, P. & Lemke, G. A relative signalling model for the formation of a topographic neural map. Nature 431, 847-853 (2004)

Casali, A. & Struhl, G. Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein. Nature. 431, 76-80 (2004)

Dubrulle, J & Pourquié, O. fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Nature 427, 419-422 (2004)

De Joussineau, C., Soule, J., Martin, M., Anguille, C., Montcourrier, P. & Alexandre, D. Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila. Nature 426, 555-559 (2003)

Eldar, A., Dorfman, R., Weiss, D., Ashe, H., Shilo, B. Z. & Barkai, N. Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature 419, 304-308 (2002)

Ossipova, O., Bardeesy, N., DePinho, R. A. & Green, J. B. A. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nature Cell Biol. 5, 889-894 (2003)

Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L. & Anderson, K. V. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature 426, 83-87 (2003)

Montcouquiol, M., Rachel, R. A., Lanford, P. J., Copeland, N. G., Jenkins, N. A. & Kelley, M. W. Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature 423, 173-177 (2003)

Schroder, R. The genes orthodenticle and hunchback substitute for bicoid in the beetle Tribolium. Nature 422, 621-625 (2003)

Dale, J. K., Maroto, M., Dequeant, M. L., Malapert, P., McGrew, M. & Pourquié, O. Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock. Nature 421, 275-278 (2003)

Houchmandzadeh, B., Wieschaus, E. & Leibler, S. Establishment of developmental precision and proportions in the early Drosophila embryo. Nature 415, 798-802 (2002)

News and Views
Janmey, P. A. & Discher, D. E. Developmental biology: Holding it together in the eye. Nature 431, 635-636 (2004)

Schier, A. F. Developmental biology: Tail of decay. Nature 427, 403-404 (2004)

Christofori, G. Split personalities: the agonistic antagonist Sprouty. Nature Cell Biol. 5, 377-379 (2003)

Clements, W. K. & Kimelman, D. Wnt signalling gets XEEKy Nature Cell Biol. 5, 861-863 (2003)

Cohen, S. M. Developmental biology: Long-range signalling by touch. Nature 426, 503-504 (2003)

Axelrod, J. D. Strabismus comes into focus. Nature Cell Biol 4, E6-E8 (2002)


Related Milestones
1952 Symmetry breaking and computer simulation
1978 Order: it's in the genes
1986 Morphing heads
1991 Sonic hedgehog the morphogen
1997 Time for segmentation
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