Commentary
Mucosal Immunology (2008) 1, 8–10. doi:10.1038/mi.2007.8
Location, location, location: B-cell differentiation in the gut lamina propria
- 1Department of Pathology and Laboratory Medicine of Weill Medical College of Cornell University, New York, New York, USA
- 2Weill Graduate School of Medical Sciences of Cornell University, New York, New York, USA
Correspondence: A Cerutti, (acerutti@med.cornell.edu)
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Abstract
The intestinal immune system includes an immunoglobulin (Ig)A-inductive site represented by Peyer's patches (PPs) and an IgA effector site represented by the lamina propria (LP). This canonical map of intestinal IgA production has been blurred recently by studies showing the presence of active IgA class switching in the LP. Here we discuss the functional implications and controversial nature of these findings.
