FOCUS
Host defense and immunity to Mycobacterium tuberculosis
Pulmonary tuberculosis, caused by Mycobacterium tuberculosis infection remains an important cause of morbidity and mortality worldwide, currently accounting for over 8 million new infections and approximately 1.5 million deaths annually. Furthermore, there is a significant spread of drug-resistant organisms, and no broadly effective vaccine strategies are presently available. The continuing global epidemic of tuberculosis emphasizes the urgent need to improve our knowledge of host defense mechanisms and to develop effective strategies for the prevention and treatment of this devastating disease.
This Web Focus is a compilation of the most pertinent original research, commentaries, and review articles published in Mucosal Immunology over the past three years addressing the immunology of tuberculosis and efforts to develop novel vaccines. We hope that the articles will inspire novel thinking about this infection of world-wide significance.
Review
The role of IL-10 in immune regulation during M. tuberculosis infection FREE
P S Redford, P J Murray and A O'Garra
Mucosal Immunology 4: 261-270; Published online, 30 March 2011; doi:10.1038/mi.2011.7
Initiation and regulation of T-cell responses in tuberculosis FREE
K B Urdahl, S Shafiani and J D Ernst
Mucosal Immunology 4: 288-293; Published online, 30 March 2011; doi:10.1038/mi.2011.10
Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis FREE
S M Behar, C J Martin, M G Booty, T Nishimura, X Zhao, H-X Gan, M Divangahi and H G Remold
Mucosal Immunology 4: 279-287; Published online, 09 February 2011; doi:10.1038/mi.2011.3
Role of innate cytokines in mycobacterial infection FREE
A M Cooper, K D Mayer-Barber and A Sher
Mucosal Immunology 4: 252-260; Published online, 23 March 2011; doi:10.1038/mi.2011.13
Macrophages and control of granulomatous inflammation in tuberculosis FREE
J L Flynn, J Chan and P L Lin
Mucosal Immunology 4: 271-278; Published online, 23 March 2011; doi:10.1038/mi.2011.14
Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections FREE
M Guilliams, B N Lambrecht and H Hammad
Mucosal Immunology 6: 464-473; Published online, 03 April 2013; doi:10.1038/mi.2013.14
Harnessing local and systemic immunity for vaccines against tuberculosis FREE
P C L Beverley, S Sridhar, A Lalvani and E Z Tchilian
Mucosal Immunology 7: 20-26; Published online, 20 November 2013; doi:10.1038/mi.2013.99
Commentary
The impact of mucosal infections on acquisition and progression of tuberculosis FREE
S Perry, R Hussain and J Parsonnet
Mucosal Immunology 4: 246-251; Published online, 16 March 2011; doi:10.1038/mi.2011.11
Article
Interleukin-17-dependent CXCL13 mediates mucosal vaccine–induced immunity against tuberculosis FREE
R Gopal, J Rangel-Moreno, S Slight, Y Lin, H F Nawar, B A Fallert Junecko, T A Reinhart, J Kolls, T D Randall, T D Connell and S A Khader
Mucosal Immunology 6: 972-984; Published online, 09 January 2013; doi:10.1038/mi.2012.135
Differentially imprinted innate immunity by mucosal boost vaccination determines antituberculosis immune protective outcomes, independent of T-cell immunity FREE
M Jeyanathan, D Damjanovic, C R Shaler, R Lai, M Wortzman, C Yin, A Zganiacz, B D Lichty and Z Xing
Mucosal Immunology 6: 612-625; Published online, 07 November 2012; doi:10.1038/mi.2012.103
Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells FREE
H Dong, O Stanek, F Rudilla Salvador, U Länger, E Morillon, C Ung, P Sebo, C Leclerc and L Majlessi
Mucosal Immunology 6: 522-534; Published online, 03 October 2012; doi:10.1038/mi.2012.92
Pulmonary M. tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells FREE
M Jeyanathan, S McCormick, R Lai, S Afkhami, C R Shaler, C N Horvath, D Damjanovic, A Zganiacz, N Barra, A Ashkar, M Jordana, N Aoki and Z Xing
Mucosal Immunology 7: 670-683; Published online, 30 October 2013; doi:10.1038/mi.2013.86