SPOTLIGHTS
The Leukemia SPOTLIGHTS focus on topical research in the field and contain both reviews and original manuscripts:
Chronic Myeloid Leukemia
Guest Editor: Prof. A Hochaus
Chronic myeloid leukemia (CML) was probably the first form of leukemia to be recognized as a distinct entity. Further, CML was the first neoplastic disease being associated with a consistent molecular-cytogenetic aberration, the Ph chromosome with the constitutively active BCR-ABL fusion gene. With this spotlight we seek to summarize recent advances in knowledge related to the pathogenesis of CML and indicate where these may have important therapeutic implications.
Myeloma
Guest Editor: Prof. V Rajkumar
This series of review articles covers recent advances in the biology and treatment of multiple myeloma. The series also includes authoritative consensus statements on controversial and evolving areas including diagnostic and response criteria, molecular classification, and new laboratory tests. These reviews will be an invaluable resource for practicing clinicians, laboratory scientists, and other hematologists.
Genomics
Guest Editor: Prof. A Ferrando
This Spotlight is devoted to Genomics and to the unraveling of the molecular basis of leukemias and germane diseases. As we enter a new era in science, compelling us to reinterpret the meaning of our experiments and leading us to new categories of diagnostic and prognostic groups, we are obliged to embrace an utterly staggering number and complex network of genes.
Myeloproliferative Neoplasms
Guest Editor: Prof. A Tefferi
The most up-to-date information regarding the history, classification, molecular pathogenesis, stem cell biology, bone marrow morphology, disease complications including thrombosis, prognosis and treatment of the BCR-ABL-negative myeloproliferative neoplasms (MPN) and related disorders.
Reduced-intensity Conditioning
Guest Editor: Prof. M Mohty
The so-called reduced intensity conditioning (RIC) regimens for allogeneic stem cell transplantation have emerged as an attractive modality to harness the immune graft-versus-tumor effect while attempting to overcome toxicity. This spotlight offers a compendium of articles providing an exciting overview and an important source of timely information on the state-of-the-art research on a broad range of clinical topics related to RIC.
Stem Cells
Guest Editor: Prof. MZ Ratajczak
The topics related to stem cells impact on many facets. In this spotlight we address new experimentation going on in the field, with special attention to novel evidence that alters our perception of the long-established dogma concerning normal hematopoietic and leukemic stem cell phenotype and function.
