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Molecular subtypes predict therapeutic responses and identifying and validating diagnostic signatures based on machine learning in chronic myeloid leukemia
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References
Eadie LN, Dang P, Saunders VA, Yeung DT, Osborn MP, Grigg AP et al. The clinical significance of ABCB1 overexpression in predicting outcome of CML patients undergoing first-line imatinib treatment. Leukemia 2016; e-pub ahead of print 15 July 2016; doi:10.1038/leu.2016.179.
Wang L, Giannoudis A, Lane S, Williamson P, Pirmohamed M, Clark RE . Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. Clin Pharmacol Ther 2008; 83: 258–264.
White DL, Dang P, Engler J, Frede A, Zrim S, Osborn M et al. Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic phase chronic myeloid leukemia treated with imatinib. J Clin Oncol 2010; 28: 2761–2767.
Razga F, Racil Z, Machova Polakova K, Buresova L, Klamova H, Zackova D et al. The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia. Int J Hematol 2011; 94: 303–306.
Racil Z, Razga F, Buresova L, Jurcek T, Dvorakova D, Zackova D et al. The assessment of human organic cation transporter 1 (hOCT1 mRNA expression in patients with chronic myelogenous leukemia is affected by the proportion of different cells types in the analyzed cell population. Am J Hematol 2010; 85: 525–528.
Racil Z, Razga F, Polakova KM, Buresova L, Polivkova V, Dvorakova D et al. Assessment of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1 mRNA expression in patients with de novo chronic myelogenous leukemia: the role of different cell types. Leuk Lymphoma 2011; 52: 331–334.
Picard S, Titier K, Etienne G, Teilhet E, Ducint D, Bernard MA et al. Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood 2007; 109: 3496–3499.
Racil Z, Razga F, Klamova H, Voglova J, Belohlavkova P, Malaskova L et al. No clinical evidence for performing trough plasma and intracellular imatinib concentrations monitoring in patients with chronic myelogenous leukaemia. Hematol Oncol 2014; 32: 87–93.
Acknowledgements
This work was supported by the Slovak Research and Developmental Agency under Contract No. APVV-15-0215 and by VEGA Grant No. 2/0094/15. Rázga is receiving support within the SASPRO Programme (Project No. 0057/01/02) co-funded by the European Union and the Slovak Academy of Sciences.
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Némethová, V., Rázga, F. Overexpression of ABCB1 as prediction marker for CML: How close we are to translation into clinics?. Leukemia 31, 266–267 (2017). https://doi.org/10.1038/leu.2016.266
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DOI: https://doi.org/10.1038/leu.2016.266
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