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Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice
Scientific Reports Open Access 28 September 2016
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References
Li Keqin Kathy, Luo Liu-Fei, Shen Yang, Xu Jie, Chen Zhu, Chen Sai-Juan . DNA methyltransferases in hematologic malignancies. Semin Hematol 2013; 50: 48–60.
Kim MS, Kim YR, Yoo NJ, Lee SH . Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers. APMIS 2013; 121: 85–94.
Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 2011; 44: 23–31.
Shah MY, Vasanthakumar A, Barnes NY, Figueroa ME, Kamp A, Hendrick C et al. DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res 2010; 70: 5840–5850.
Hlady RA, Novakova S, Opavska J, Klinkebiel D, Peters SL, Bies J et al. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest 2012; 122: 163–177.
Vasanthakumar A, Lepore JB, Zegarek MH, Kocherginsky M, Singh M, Davis EM et al. Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis. Blood 2013; 121: 2059–2063.
Nguyen S, Meletis K, Fu D, Jhaveri S, Jaenisch R . Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan. Dev Dyn 2007; 236: 1663–1676.
Peters SL, Hlady RA, Opavska J, Klinkebiel D, Novakova S, Smith LM et al. Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas. Mol Cell Biol 2013; 33: 4321–4333.
Ji H, Ehrlich LI, Seita J, Murakami P, Doi A, Lindau P et al. Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature 2010; 467: 338–342.
Haferlach T, Kohlmann A, Wieczorek L, Basso G, Kronnie GT, Béné MC et al. Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol 2010; 28: 2529–2537.
Kulis M, Heath S, Bibikova M, Queirós AC, Navarro A, Clot G et al. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia. Nat Genet 2012; 44: 1236–1242.
Palamarchuk A, Yan PS, Zanesi N, Wang L, Rodrigues B, Murphy M et al. Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL). Proc Natl Acad Sci USA 2012; 109: 2555–2560.
Walter MJ, Ding L, Shen D, Shao J, Grillot M, McLellan M et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 2011; 25: 1153–1158.
Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 2012; 48: 506–510.
Kaneda M, Okano M, Hata K, Sado T, Tsujimoto N, Li E et al. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 2004; 429: 900–903.
Acknowledgements
The authors thank the UNMC Flow Cytometry and Tissue Sciences Facilities. This work was supported by an Eppley Cancer Center pilot project grant (RO), the Nebraska Cancer and Smoking Disease Research Program NE DHHS LB506 2012-28 (RO), the National Center for Research Resources and the National Institutes of Health grant 5P20GM103489. RAH and SLP were supported by a UNMC assistanceship/fellowship.
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Peters, S., Hlady, R., Opavska, J. et al. Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis. Leukemia 28, 1138–1142 (2014). https://doi.org/10.1038/leu.2013.364
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DOI: https://doi.org/10.1038/leu.2013.364
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