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Higher expression levels of activation-induced cytidine deaminase distinguish hairy cell leukemia from hairy cell leukemia-variant and splenic marginal zone lymphoma

Leukemia volume 24, pages 1084–1086 (2010)Cite this article

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Hairy cell leukemia (HCL), HCL-variant and splenic marginal zone lymphoma (SMZL) are B-cell disorders that have several pathological features in common, making their distinction at diagnosis sometimes difficult.1 The normal B-cell counterparts from which these disorders derive are still under debate, and their resemblance suggests that they may share a common clonal progenitor in the splenic marginal zone.

Analysis of the immunoglobulin heavy chain (IGH) locus rearrangements can provide insight into the clonal origin of B-cell disorders. It can determine whether the cell of origin has undergone somatic hypermutation (SHM) and class-switch recombination (CSR) events in response to antigen encounter, and thus can be used to classify disorders based on the B-cell differentiation or activation stage at which they appear to be arrested. SHM and CSR commonly take place in the germinal center (GC), but recent evidence suggests that they can less frequently occur outside of this microenvironment.2

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Acknowledgements

We thank Dr Mark Catherwood for providing some of the FL controls used in this study.

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  1. E Matutes and D Gonzalez: These authors contributed equally to this work.

Authors and Affiliations

  1. Section of Hemato-Oncology, The Institute of Cancer Research, Sutton, Surrey, UK

    S L Hockley, A Morilla, M Else, C Dearden, D Catovsky, G J Morgan, E Matutes & D Gonzalez

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  1. S L Hockley
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  2. A Morilla
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Correspondence to D Gonzalez.

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Hockley, S., Morilla, A., Else, M. et al. Higher expression levels of activation-induced cytidine deaminase distinguish hairy cell leukemia from hairy cell leukemia-variant and splenic marginal zone lymphoma. Leukemia 24, 1084–1086 (2010). https://doi.org/10.1038/leu.2010.44

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