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Rapid flow cytometric detection of aberrant cytoplasmic localization of nucleophosmin (NPMc) indicating mutant NPM1 gene in acute myeloid leukemia

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Acknowledgements

We thank all participating study centers for including their patients in the SAL trials. Generation of monoclonal antibodies anti-NPM1 (clones 322 and 376) was supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC). This work was supported in part through BMBF grants no. 01GS0872 and 03WKBH2H to CT. The excellent skills of technicians Claudia Garten, Marika Karger, Sandra Kleiner; data manager Catrin Theuser; and statistician Michael Kramer are gratefully acknowledged. We further thank Michelle Meredyth-Stewart for her advice in preparing the manuscript.

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Correspondence to C Thiede.

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BF has applied for a patent on the clinical use of NPM1 mutants. The other authors declare no conflict of interest.

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Oelschlaegel, U., Koch, S., Mohr, B. et al. Rapid flow cytometric detection of aberrant cytoplasmic localization of nucleophosmin (NPMc) indicating mutant NPM1 gene in acute myeloid leukemia. Leukemia 24, 1813–1816 (2010). https://doi.org/10.1038/leu.2010.178

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