TABLE OF CONTENTS
Volume 23, Issue 3 (March 2009)
Editorial
Is angiogenesis essential for the progression of hematological malignancies or is it an epiphenomenon?
D Ribatti
Leukemia 23: 433-434; doi:10.1038/leu.2008.381
Spotlight Reviews
Pathogenesis of myeloma bone disease FREE
G D Roodman
Leukemia 23: 435-441; advance online publication, November 27, 2008; doi:10.1038/leu.2008.336
Role of autologous and allogeneic stem cell transplantation in myeloma FREE
W I Bensinger
Leukemia 23: 442-448; advance online publication, January 29, 2009; doi:10.1038/leu.2008.396
Treatment of newly diagnosed myeloma FREE
A Palumbo and S V Rajkumar
Leukemia 23: 449-456; advance online publication, November 13, 2008; doi:10.1038/leu.2008.325
Reviews
Treatment of B-cell chronic lymphocytic leukemia with nonchemotherapeutic agents: experience with single-agent and combination therapy
S Faderl, A Ferrajoli, O Frankfurt and A Pettitt
Leukemia 23: 457-466; advance online publication, November 6, 2008; doi:10.1038/leu.2008.322
Inhibitor of apoptosis proteins in hematological malignancies
S Fulda
Leukemia 23: 467-476; advance online publication, November 27, 2008; doi:10.1038/leu.2008.329
Original Articles
Molecular Targets for Therapy
Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells
L L Remsing Rix, U Rix, J Colinge, O Hantschel, K L Bennett, T Stranzl, A Müller, C Baumgartner, P Valent, M Augustin, J H Till and G Superti-Furga
Leukemia 23: 477-485; advance online publication, November 27, 2008; doi:10.1038/leu.2008.334
Acute Leukemias
CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy
A Pérez-García, S Brunet, J J Berlanga, M Tormo, J Nomdedeu, R Guardia, J M Ribera, I Heras, A Llorente, M Hoyos, J Esteve, J Besalduch, J Bueno, J Sierra and D Gallardo 'Grupo cooperativo para el estudio y tratamiento de las leucemias agudas y mielodisplasias' (CETLAM)
Leukemia 23: 486-491; advance online publication, December 18, 2008; doi:10.1038/leu.2008.339
KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia
R Willemze, C A Rodrigues, M Labopin, G Sanz, G Michel, G Socié, B Rio, A Sirvent, M Renaud, L Madero, M Mohty, C Ferra, F Garnier, P Loiseau, J Garcia, L Lecchi, G Kögler, Y Beguin, C Navarrete, T Devos, I Ionescu, K Boudjedir, A-L Herr, E Gluckman and V Rocha on behalf of Eurocord-Netcord and Acute Leukaemia Working Party of the EBMT, Paris (F)
Leukemia 23: 492-500; advance online publication, January 8, 2009; doi:10.1038/leu.2008.365
A dose-dependent tug of war involving the NPM1 leukaemic mutant, nucleophosmin, and ARF
N Bolli, M F De Marco, M P Martelli, B Bigerna, A Pucciarini, R Rossi, R Mannucci, N Manes, V Pettirossi, S A Pileri, I Nicoletti and B Falini
Leukemia 23: 501-509; advance online publication, November 13, 2008; doi:10.1038/leu.2008.326
Myelodysplasias
Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS)
I Kotsianidis, I Bouchliou, E Nakou, E Spanoudakis, D Margaritis, A V Christophoridou, A Anastasiades, C Tsigalou, G Bourikas, A Karadimitris and C Tsatalas
Leukemia 23: 510-518; advance online publication, November 20, 2008; doi:10.1038/leu.2008.333
Chronic Lymphocytic Leukemia
The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia
K Giannopoulos, D Mertens, A Bühler, T F E Barth, I Idler, P Möller, A Kröber, J Greiner, S Chocholska, A Dmoszyñska, J Roliñski, H Döhner, S Stilgenbauer and M Schmitt
Leukemia 23: 519-527; advance online publication, December 18, 2008; doi:10.1038/leu.2008.338
Minimal Residual Disease
Monitoring treatment response of childhood precursor B-cell acute lymphoblastic leukemia in the AIEOP-BFM-ALL 2000 protocol with multiparameter flow cytometry: predictive impact of early blast reduction on the remission status after induction
R Ratei, G Basso, M Dworzak, G Gaipa, M Veltroni, P Rhein, A Biondi, M Schrappe, W-D Ludwig and L Karawajew for the AIEOP-BFM-FCM-MRD-Study Group
Leukemia 23: 528-534; advance online publication, November 20, 2008; doi:10.1038/leu.2008.324
Immunology
Post-transcriptional regulation of adapter molecules by IL-10 inhibits TLR-mediated activation of antigen-presenting cells
A Knödler, S M Schmidt, A Bringmann, M M Weck, K M Brauer, T A W Holderried, A-K Heine, F Grünebach and P Brossart
Leukemia 23: 535-544; advance online publication, November 13, 2008; doi:10.1038/leu.2008.301
Pharmacogenomics
Association of drug metabolism gene polymorphisms with toxicities, graft-versus-host disease and survival after HLA-identical sibling hematopoietic stem cell transplantation for patients with leukemia
V Rocha, R Porcher, J F Fernandes, A Filion, H Bittencourt, W Silva Jr, G Vilela, D L Zanette, C Ferry, J Larghero, A Devergie, P Ribaud, Y Skvortsova, R Tamouza, E Gluckman, G Socie and M A Zago
Leukemia 23: 545-556; advance online publication, November 13, 2008; doi:10.1038/leu.2008.323
Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
K Schmiegelow, E Forestier, J Kristinsson, S Söderhäll, K Vettenranta, R Weinshilboum and F Wesenberg On behalf of the Nordic Society of Paediatric Haematology and Oncology (NOPHO)
Leukemia 23: 557-564; advance online publication, November 6, 2008; doi:10.1038/leu.2008.316
Lymphoma
The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed–Sternberg cells
H Knecht, B Sawan, D Lichtensztejn, B Lemieux, R J Wellinger and S Mai
Leukemia 23: 565-573; advance online publication, November 27, 2008; doi:10.1038/leu.2008.314
Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas
A L Feldman, M Law, E D Remstein, W R Macon, L A Erickson, K L Grogg, P J Kurtin and A Dogan
Leukemia 23: 574-580; advance online publication, November 6, 2008; doi:10.1038/leu.2008.320
Letters to the Editor
Expression profiling of persistent polyclonal B-cell lymphocytosis suggests constitutive expression of the AP-1 transcription complex and downregulation of Fas-apoptotic and TGF
signalling pathways
C H Lawrie, R Shilling, X Troussard, H Cattan, H Mossafa, F Pezzella, J Boultwood, J S Wainscoat and C S R Hatton
Leukemia 23: 581-583; advance online publication, August 28, 2008; doi:10.1038/leu.2008.223
Alterations of NFIA in chronic malignant myeloid diseases
F Bernard, V Gelsi-Boyer, A Murati, S Giraudier, V Trouplin, J Adélaïde, J Rey, S Olschwang, W Vainchenker, M Chaffanet, N Vey, M J Mozziconacci and D Birnbaum
Leukemia 23: 583-585; advance online publication, August 28, 2008; doi:10.1038/leu.2008.228
Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma
X Mao, X Li, R Sprangers, X Wang, A Venugopal, T Wood, Y Zhang, D A Kuntz, E Coe, S Trudel, D Rose, R A Batey, L E Kay and A D Schimmer
Leukemia 23: 585-590; advance online publication, August 28, 2008; doi:10.1038/leu.2008.232
Dasatinib is a potent inhibitor of tumour-associated macrophages, osteoclasts and the FMS receptor
N Brownlow, C Mol, C Hayford, S Ghaem-Maghami and N J Dibb
Leukemia 23: 590-594; advance online publication, September 11, 2008; doi:10.1038/leu.2008.237
Noxa upregulation is associated with apoptosis of chronic lymphocytic leukemia cells induced by hyperforin but not flavopiridol
M Zaher, I Akrout, M Mirshahi, J-P Kolb and C Billard
Leukemia 23: 594-596; advance online publication, September 11, 2008; doi:10.1038/leu.2008.239
Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma
S S Wang, M J Maurer, L M Morton, T M Habermann, S Davis, W Cozen, C F Lynch, R K Severson, N Rothman, S J Chanock, P Hartge and J R Cerhan
Leukemia 23: 596-602; advance online publication, October 2, 2008; doi:10.1038/leu.2008.240
Clinical trials underestimate the age of chronic myeloid leukemia (CML) patients. Incidence and median age of Ph/BCR-ABL-positive CML and other chronic myeloproliferative disorders in a representative area in Germany
M Rohrbacher, U Berger, A Hochhaus, G Metzgeroth, K Adam, T Lahaye, S Saussele, M C Müller, J Hasford, H Heimpel and R Hehlmann
Leukemia 23: 602-604; advance online publication, September 11, 2008; doi:10.1038/leu.2008.245
Lenalidomide alone or in combination with dexamethasone is highly effective in patients with relapsed multiple myeloma following allogeneic stem cell transplantation and increases the frequency of CD4+Foxp3+ T cells
M C Minnema, M S van der Veer, T Aarts, M Emmelot, T Mutis and H M Lokhorst
Leukemia 23: 605-607; advance online publication, September 11, 2008; doi:10.1038/leu.2008.247
Non-myeloablative transplantation with CD8-depleted or unmanipulated peripheral blood stem cells: a phase II randomized trial
E Willems, F Baron, E Baudoux, N Wanten, L Seidel, J-F Vanbellinghen, C Herens, A Gothot, P Frère, C Bonnet, K Hafraoui, G Vanstraelen, G Fillet and Y Beguin
Leukemia 23: 608-610; advance online publication, September 18, 2008; doi:10.1038/leu.2008.248
UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation
H Szpurka, L P Gondek, S R Mohan, E D Hsi, K S Theil and J P Maciejewski
Leukemia 23: 610-614; advance online publication, September 25, 2008; doi:10.1038/leu.2008.249
A novel translocation, t(14;19)(q32;p13), involving IGH@ and the cytokine receptor for erythropoietin
L J Russell, D G De Castro, M Griffiths, N Telford, O Bernard, R Panzer-Grümayer, O Heidenreich, A V Moorman and C J Harrison
Leukemia 23: 614-617; advance online publication, September 25, 2008; doi:10.1038/leu.2008.250
Stimulation of B-cell lymphoproliferations with CpG-oligonucleotide DSP30 plus IL-2 is more effective than with TPA to detect clonal abnormalities
S Struski, C Gervais, C Helias, R Herbrecht, B Audhuy and L Mauvieux
Leukemia 23: 617-619; advance online publication, October 2, 2008; doi:10.1038/leu.2008.252
PET imaging of T cells derived from umbilical cord blood
H Singh, A M Najjar, S Olivares, R Nishii, U Mukhopadhyay, M Alauddin, P R Manuri, H Huls, D A Lee, G Dotti, C Bollard, P J Simmons, E J Shpall, R E Champlin, J G Gelovani and L J N Cooper
Leukemia 23: 620-622; advance online publication, October 2, 2008; doi:10.1038/leu.2008.256
Survivin expression in the bone marrow of patients with severe congenital neutropenia
G Carlsson, S Boxhammer, D Garwicz, J I Henter, J Palmblad, M Nordenskjöld, A Porwit and B Fadeel
Leukemia 23: 622-625; advance online publication, September 25, 2008; doi:10.1038/leu.2008.258
17p13/TP53 deletion in B-CLL patients is associated with microRNA-34a downregulation
M K Dijkstra, K van Lom, D Tielemans, F Elstrodt, A W Langerak, M B van 't Veer and M Jongen-Lavrencic
Leukemia 23: 625-627; advance online publication, September 25, 2008; doi:10.1038/leu.2008.264
Rapid complete cytogenetic remission after upfront dasatinib monotherapy in a patient with a NUP214-ABL1-positive T-cell acute lymphoblastic leukemia
W Deenik, H B Beverloo, S C P A M van der Poel-van de Luytgaarde, M M Wattel, J W J van Esser, P J M Valk and J J Cornelissen
Leukemia 23: 627-629; advance online publication, November 6, 2008; doi:10.1038/leu.2008.318
Corrigendum
KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia FREE
R Willemze, C A Rodrigues, M Labopin, G Sanz, G Michel, G Socié, B Rio, A Sirvent, M Renaud, L Madero, M Mohty, C Ferra, F Garnier, P Loiseau, J Garcia, L Lecchi, G Kögler, Y Beguin, C Navarrete, T Devos, I Ionescu, K Boudjedir, A-L Herr, E Gluckman and V Rocha on behalf of Eurocord-Netcord and Acute Leukaemia Working Party of the EBMT, Paris (F)
Leukemia 23: 630; doi:10.1038/leu.2009.11
