TABLE OF CONTENTS
Volume 23, Issue 2 (February 2009)
Spotlight Review
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders FREE
A Dispenzieri, R Kyle, G Merlini, J S Miguel, H Ludwig, R Hajek, A Palumbo, S Jagannath, J Blade, S Lonial, M Dimopoulos, R Comenzo, H Einsele, B Barlogie, K Anderson, M Gertz, J L Harousseau, M Attal, P Tosi, P Sonneveld, M Boccadoro, G Morgan, P Richardson, O Sezer, M V Mateos, M Cavo, D Joshua, I Turesson, W Chen, K Shimizu, R Powles, S V Rajkumar and B G M Durie on behalf of the International Myeloma Working Group
Leukemia 23: 215-224; advance online publication, November 20, 2008; doi:10.1038/leu.2008.307
Review
Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge
E G Boerma, R Siebert, P M Kluin and M Baudis
Leukemia 23: 225-234; advance online publication, October 16, 2008; doi:10.1038/leu.2008.281
Original Articles
Molecular Targets for Therapy
Molecular recognition of acute myeloid leukemia using aptamers
K Sefah, Z W Tang, D H Shangguan, H Chen, D Lopez-Colon, Y Li, P Parekh, J Martin, L Meng, J A Phillips, Y M Kim and W H Tan
Leukemia 23: 235-244; advance online publication, January 8, 2009; doi:10.1038/leu.2008.335
Acute Leukemias
Clinical consequences of hyperglycemia during remission induction therapy for pediatric acute lymphoblastic leukemia
J R Roberson, H L Spraker, J Shelso, Y Zhou, H Inaba, M L Metzger, J E Rubnitz, R C Ribeiro, J T Sandlund, S Jeha, C-H Pui and S C Howard
Leukemia 23: 245-250; advance online publication, October 16, 2008; doi:10.1038/leu.2008.289
The role of VEGF and a functional link between VEGF and p27Kip1 in acute myeloid leukemia
B Wegiel, J Ekberg, K M Talasila, S Jalili and J L Persson
Leukemia 23: 251-261; advance online publication, November 6, 2008; doi:10.1038/leu.2008.300
Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML
I H I M Hollink, C M Zwaan, M Zimmermann, T C J M Arentsen-Peters, R Pieters, J Cloos, G J L Kaspers, S S N de Graaf, J Harbott, U Creutzig, D Reinhardt, M M van den Heuvel-Eibrink and C Thiede
Leukemia 23: 262-270; advance online publication, November 20, 2008; doi:10.1038/leu.2008.313
Chronic Myeloproliferative Neoplasias
The molecular anatomy of the FIP1L1-PDGFRA fusion gene
C Walz, J Score, J Mix, D Cilloni, C Roche-Lestienne, R-F Yeh, J L Wiemels, E Ottaviani, P Erben, A Hochhaus, M Baccarani, D Grimwade, C Preudhomme, J Apperley, G Martinelli, G Saglio, N C P Cross and A Reiter on behalf of the European LeukemiaNet
Leukemia 23: 271-278; advance online publication, November 6, 2008; doi:10.1038/leu.2008.310
BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold
J Dierov, P V Sanchez, B A Burke, H Padilla-Nash, M E Putt, T Ried and M Carroll
Leukemia 23: 279-286; advance online publication, November 20, 2008; doi:10.1038/leu.2008.308
Telomere length is severely and similarly reduced in JAK2V617F-positive and -negative myeloproliferative neoplasms
L Bernard, C Belisle, L Mollica, S Provost, D-C Roy, D G Gilliland, R L Levine and L Busque
Leukemia 23: 287-291; advance online publication, November 13, 2008; doi:10.1038/leu.2008.319
Chronic Lymphocytic Leukemia
Treatment of primary CLL cells with bezafibrate and medroxyprogesterone acetate induces apoptosis and represses the pro-proliferative signal of CD40-ligand, in part through increased 15d
12,14,PGJ2
R E Hayden, G Pratt, N J Davies, F L Khanim, J Birtwistle, J Delgado, C Pearce, T Sant, M T Drayson and C M Bunce
Leukemia 23: 292-304; advance online publication, October 16, 2008; doi:10.1038/leu.2008.283
Stem Cells
Stem cell factor and high-dose twice daily filgrastim is an effective strategy for peripheral blood stem cell mobilization in patients with indolent lymphoproliferative disorders previously treated with fludarabine: results of a Phase II study with an historical comparator
K E Herbert, S Morgan, H M Prince, D A Westerman, M M Wolf, D A Carney, K Yuen, J di Iulio and J F Seymour
Leukemia 23: 305-312; advance online publication, November 6, 2008; doi:10.1038/leu.2008.302
Cytogenetics and Molecular Genetics
Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia
D Schotte, J C K Chau, G Sylvester, G Liu, C Chen, V H J van der Velden, M J C Broekhuis, T C J M Peters, R Pieters and M L den Boer
Leukemia 23: 313-322; advance online publication, October 16, 2008; doi:10.1038/leu.2008.286
Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB/LMB 96 international study
H A Poirel, M S Cairo, N A Heerema, J Swansbury, A Aupérin, E Launay, W G Sanger, P Talley, S L Perkins, M Raphaël, K McCarthy, R Sposto, M Gerrard, A Bernheim and C Patte on behalf of the FAB/LMB 96 International Study Committee
Leukemia 23: 323-331; advance online publication, November 20, 2008; doi:10.1038/leu.2008.312
Minimal Residual Disease
Detection and molecular monitoring of FIP1L1-PDGFRA-positive disease by analysis of patient-specific genomic DNA fusion junctions
J Score, C Walz, J V Jovanovic, A V Jones, K Waghorn, C Hidalgo-Curtis, F Lin, D Grimwade, F Grand, A Reiter and N C P Cross
Leukemia 23: 332-339; advance online publication, November 6, 2008; doi:10.1038/leu.2008.309
Immunology
Allogeneic bone marrow transplantation and donor lymphocyte infusion in a mouse model of irradiation-induced myelodysplastic/myeloproliferation syndrome (MD/MPS): evidence for a graft-versus-MD/MPS effect
B Sprangers, B Van Wijmeersch, A Luyckx, X Sagaert, L De Somer, O Rutgeerts, C Lenaerts, W Landuyt, N Boeckx, B Dubois, C De Wolf-Peeters, M Waer and A D Billiau
Leukemia 23: 340-349; advance online publication, November 6, 2008; doi:10.1038/leu.2008.298
Sensitivity and Resistance to Therapy
Early clearance of peripheral blasts measured by flow cytometry during the first week of AML induction therapy as a new independent prognostic factor: a GOELAMS study
F Lacombe, C Arnoulet, M Maynadié, E Lippert, I Luquet, A Pigneux, N Vey, O Casasnovas, F Witz and M C Béné
Leukemia 23: 350-357; advance online publication, November 6, 2008; doi:10.1038/leu.2008.296
Oncogenes, Fusion Genes and Tumor Suppressor Genes
Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1/CSF1R signaling abnormalities in the cell line GDM1
A Chase, B Schultheis, S Kreil, J Baxter, C Hidalgo-Curtis, A Jones, L Zhang, F H Grand, J V Melo and N C P Cross
Leukemia 23: 358-364; advance online publication, October 30, 2008; doi:10.1038/leu.2008.295
Apoptosis
C/EBP
or C/EBP oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-
B p50 bound to the bcl-2 and FLIP gene promoters
I Paz-Priel, A K Ghosal, J Kowalski and A D Friedman
Leukemia 23: 365-374; advance online publication, November 6, 2008; doi:10.1038/leu.2008.297
Lymphoma
PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients
T Kozako, M Yoshimitsu, H Fujiwara, I Masamoto, S Horai, Y White, M Akimoto, S Suzuki, K Matsushita, K Uozumi, C Tei and N Arima
Leukemia 23: 375-382; advance online publication, October 2, 2008; doi:10.1038/leu.2008.272
Myeloma
DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway
V Ullmannova-Benson, M Guan, X Zhou, V Tripathi, X-Y Yang, D B Zimonjic and N C Popescu
Leukemia 23: 383-390; advance online publication, October 16, 2008; doi:10.1038/leu.2008.285
Letters to the Editor
Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells
D L Stirewalt, Y E Choi, N E Sharpless, E L Pogosova-Agadjanyan, M R Cronk, M Yukawa, E B Larson, B L Wood, F R Appelbaum, J P Radich and S Heimfeld
Leukemia 23: 391-393; advance online publication, July 3, 2008; doi:10.1038/leu.2008.176
Combining SDF-1/CXCR4 antagonism and chemotherapy in relapsed acute myeloid leukemia
F A Fierro, S Brenner, U Oelschlaegel, A Jacobi, H Knoth, G Ehninger, T Illmer and M Bornhäuser
Leukemia 23: 393-396; advance online publication, July 10, 2008; doi:10.1038/leu.2008.182
Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR
V G Oehler, J Qin, R Ramakrishnan, G Facer, S Ananthnarayan, C Cummings, M Deininger, N Shah, F McCormick, S Willis, A Daridon, M Unger and J P Radich
Leukemia 23: 396-399; advance online publication, July 10, 2008; doi:10.1038/leu.2008.183
Kinetics of humoral response to ALK and its relationship with minimal residual disease in pediatric ALCL
L Mussolin, P Bonvini, K Ait-Tahar, M Pillon, G Tridello, S Buffardi, A Lombardi, K Pulford and A Rosolen
Leukemia 23: 400-402; advance online publication, July 10, 2008; doi:10.1038/leu.2008.184
Coding polymorphisms in CD33 and response to gemtuzumab ozogamicin in pediatric patients with AML: a pilot study
J K Lamba, S Pounds, X Cao, J R Downing, D Campana, R C Ribeiro, C-H Pui and J E Rubnitz
Leukemia 23: 402-404; advance online publication, July 10, 2008; doi:10.1038/leu.2008.185
Acetylation of FOXO3a transcription factor in response to imatinib of chronic myeloid leukemia
P Corrado, M Mancini, G Brusa, S Petta, G Martinelli, E Barbieri and M A Santucci
Leukemia 23: 405-406; advance online publication, August 7, 2008; doi:10.1038/leu.2008.186
High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia
J W Tyner, M M Loriaux, H Erickson, C A Eide, J Deininger, M MacPartlin, S G Willis, T Lange, B J Druker, T Kovacsovics, R Maziarz, N Gattermann and M W Deininger
Leukemia 23: 406-409; advance online publication, July 10, 2008; doi:10.1038/leu.2008.187
Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoring of DNA damage-dependent ATM phosphorylation
M Honda, M Takagi, L Chessa, T Morio and S Mizuatni
Leukemia 23: 409-414; advance online publication, July 17, 2008; doi:10.1038/leu.2008.195
Expression of cyclin A in childhood acute lymphoblastic leukemia cells reveals undisturbed G1–S phase transition and passage through the S phase
A Hirt, A M Schmid, F Julmy, N M R Schmitz and K Leibundgut
Leukemia 23: 414-417; advance online publication, July 31, 2008; doi:10.1038/leu.2008.200
Redundant function of retinoic acid receptor isoforms in leukemogenesis unravels a prominent function of genome topology and architecture in the selection of mutagenic events in cancer
A Marinelli, D Bossi, P G Pelicci and S Minucci
Leukemia 23: 417-419; advance online publication, August 7, 2008; doi:10.1038/leu.2008.205
Long-term follow-up of 111 patients with persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes
E Cornet, J F Lesesve, H Mossafa, G Sébahoun, V Levy, F Davi and X Troussard and the Groupe Français d'Hématologie Cellulaire (GFHC)
Leukemia 23: 419-422; advance online publication, July 31, 2008; doi:10.1038/leu.2008.208
The research mission in myeloma
P G Richardson, J San-Miguel, S Lonial, D Reece, A Jakubowiak, M Hussein, S Jagannath, C S Mitsiades, N Raje, J Kaufman, D Avigan, I Ghobrial, R L Schlossman, N Munshi, W Dalton and K C Anderson
Leukemia 23: 422-423; advance online publication, August 7, 2008; doi:10.1038/leu.2008.209
Reply to the research mission in myeloma by Richardson et al.
P L Bergsagel
Leukemia 23: 423-424; advance online publication, August 7, 2008; doi:10.1038/leu.2008.211
Molecular detection of AML1-MTG8-positive cells in peripheral blood from a patient with isolated extramedullary relapse of t(8;21) acute myeloid leukemia
H Tamaki, S Yoshihara, T Fujioka, M Kawakami, Y Oka and H Ogawa
Leukemia 23: 424-426; advance online publication, August 21, 2008; doi:10.1038/leu.2008.220
The B-cell calcium sensor predicts progression of chronic lymphocytic leukemia
C M Hammond, Y Shi, D White, D Cervi, J Tomic and D E Spaner
Leukemia 23: 426-429; advance online publication, December 11, 2008; doi:10.1038/leu.2008.351
Corrigenda
Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells FREE
D L Stirewalt, Y E Choi, N E Sharpless, E L Pogosova-Agadjanyan, M R Cronk, M Yukawa, E B Larson, B L Wood, F R Appelbaum, J P Radich and S Heimfeld
Leukemia 23: 430; doi:10.1038/leu.2008.293
