Publication of this issue is partly supported via a contribution by Celgene
TABLE OF CONTENTS
Volume 23, Issue 10 (October 2009)
Editorial
Stem-cell collection before high-dose therapy for multiple myeloma: time has come to raise the standards!
M Mohty
Leukemia 23: 1689-1690; doi:10.1038/leu.2009.109
Spotlight Reviews
Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic/racial groups: support for genetic factors in pathogenesis
O Landgren and B M Weiss
Leukemia 23: 1691-1697; advance online publication, July 9, 2009; doi:10.1038/leu.2009.134
Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia
F J Giles, M O'Dwyer and R Swords
Leukemia 23: 1698-1707; advance online publication, May 28, 2009; doi:10.1038/leu.2009.111
Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues
J M Goldman, A R Green, T Holyoake, C Jamieson, R Mesa, T Mughal, F Pellicano, D Perrotti, R Skoda and A M Vannucchi
Leukemia 23: 1708-1715; advance online publication, July 30, 2009; doi:10.1038/leu.2009.142
Reviews
International Myeloma Working Group guidelines for the management of multiple myeloma patients ineligible for standard high-dose chemotherapy with autologous stem cell transplantation
A Palumbo, O Sezer, R Kyle, J S Miguel, R Z Orlowski, P Moreau, R Niesvizky, G Morgan, R Comenzo, P Sonneveld, S Kumar, R Hajek, S Giralt, S Bringhen, K C Anderson, P G Richardson, M Cavo, F Davies, J Bladé, H Einsele, M A Dimopoulos, A Spencer, A Dispenzieri, T Reiman, K Shimizu, J H Lee, M Attal, M Boccadoro, M Mateos, W Chen, H Ludwig, D Joshua, J Chim, V Hungria, I Turesson, B G M Durie and S Lonial on behalf of the IMWG
Leukemia 23: 1716-1730; advance online publication, June 4, 2009; doi:10.1038/leu.2009.122
Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications
B Falini, N Bolli, A Liso, M P Martelli, R Mannucci, S Pileri and I Nicoletti
Leukemia 23: 1731-1743; advance online publication, June 11, 2009; doi:10.1038/leu.2009.124
Original Articles
Molecular Targets for Therapy
MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM
A A Rambal, Z L G Panaguiton, L Kramer, S Grant and H Harada
Leukemia 23: 1744-1754; advance online publication, April 30, 2009; doi:10.1038/leu.2009.80
Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells
B Z Carter, D H Mak, R Woessner, S Gross, W D Schober, Z Estrov, H Kantarjian and M Andreeff
Leukemia 23: 1755-1762; advance online publication, May 21, 2009; doi:10.1038/leu.2009.101
Acute Leukemias
Reduced-intensity conditioning allogeneic stem cell transplantation is a potential therapeutic approach for adults with high-risk acute lymphoblastic leukemia in remission: results of a prospective phase 2 study
B-S Cho, S Lee, Y-J Kim, N-G Chung, K-S Eom, H-J Kim, C-K Min, S-G Cho, D-W Kim, J-W Lee, W-S Min and C-C Kim
Leukemia 23: 1763-1770; advance online publication, May 14, 2009; doi:10.1038/leu.2009.102
Chronic Lymphocytic Leukemia
Thalidomide exerts distinct molecular antileukemic effects and combined thalidomide/fludarabine therapy is clinically effective in high-risk chronic lymphocytic leukemia
K Giannopoulos, A Dmoszynska, M Kowal, E W
sik-Szczepanek, A Bojarska-Junak, J Rolinski, H Döhner, S Stilgenbauer and L Bullinger
Leukemia 23: 1771-1778; advance online publication, May 14, 2009; doi:10.1038/leu.2009.98
Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia
J E Castro, D F James, J D Sandoval-Sus, S Jain, J Bole, L Rassenti and T J Kipps
Leukemia 23: 1779-1789; advance online publication, August 20, 2009; doi:10.1038/leu.2009.133
Stem Cells
Interferon-
-induced neuronal differentiation of human umbilical cord blood-derived progenitors
H Arien-Zakay, S Lecht, M M Bercu, N Amariglio, G Rechavi, H Galski, P Lazarovici and A Nagler
Leukemia 23: 1790-1800; advance online publication, May 21, 2009; doi:10.1038/leu.2009.106
Cytogenetics and Molecular Genetics
Cytogenetic profile of de novo acute myeloid leukemia: a study based on 1432 patients in a single institution of China
Y Cheng, Y Wang, H Wang, Z Chen, J Lou, H Xu, H Wang, W Qian, H Meng, M Lin and J Jin
Leukemia 23: 1801-1806; advance online publication, May 28, 2009; doi:10.1038/leu.2009.107
Immunology
SDF-1 and PDGF enhance 
v
5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines
M Acharya, A L Edkins, B W Ozanne and W Cushley
Leukemia 23: 1807-1817; advance online publication, July 16, 2009; doi:10.1038/leu.2009.126
Characterization of BAX inhibitor-1 as a novel leukemia-associated antigen
S M Schmidt, T König, A Bringmann, S Held, K von Schwarzenberg, A Heine, T A W Holderried, S Stevanovic, F Grünebach and P Brossart
Leukemia 23: 1818-1824; advance online publication, July 16, 2009; doi:10.1038/leu.2009.138
Animal Models
Heritable T-cell malignancy models established in a zebrafish phenotypic screen
J K Frazer, N D Meeker, L Rudner, D F Bradley, A C H Smith, B Demarest, D Joshi, E E Locke, S A Hutchinson, S Tripp, S L Perkins and N S Trede
Leukemia 23: 1825-1835; advance online publication, June 11, 2009; doi:10.1038/leu.2009.116
Lymphoma
Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism
P Gelebart, Z Zak, M Anand, J Dien-Bard, H M Amin and R Lai
Leukemia 23: 1836-1846; advance online publication, June 4, 2009; doi:10.1038/leu.2009.100
Identification of MNDA as a new marker for nodal marginal zone lymphoma
G Kanellis, G Roncador, A Arribas, M Mollejo, S Montes-Moreno, L Maestre, Y Campos-Martin, J L Ríos Gonzalez, J L Martinez-Torrecuadrada, L Sanchez-Verde, R Pajares, J C Cigudosa, M C Martin and M A Piris
Leukemia 23: 1847-1857; advance online publication, May 28, 2009; doi:10.1038/leu.2009.108
Array-based DNA methylation profiling in follicular lymphoma
C O'Riain, D M O'Shea, Y Yang, R Le Dieu, J G Gribben, K Summers, J Yeboah-Afari, L Bhaw-Rosun, C Fleischmann, C A Mein, T Crook, P Smith, G Kelly, A Rosenwald, G Ott, E Campo, L M Rimsza, E B Smeland, W C Chan, N Johnson, R D Gascoyne, S Reimer, R M Braziel, G W Wright, L M Staudt, T A Lister and J Fitzgibbon
Leukemia 23: 1858-1866; advance online publication, July 9, 2009; doi:10.1038/leu.2009.114
Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma
P Gasperini and G Tosato
Leukemia 23: 1867-1874; advance online publication, June 25, 2009; doi:10.1038/leu.2009.117
Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma
H Schwindt, I Vater, M Kreuz, M Montesinos-Rongen, A Brunn, J Richter, S Gesk, O Ammerpohl, O D Wiestler, D Hasenclever, M Deckert and R Siebert
Leukemia 23: 1875-1884; advance online publication, June 4, 2009; doi:10.1038/leu.2009.120
STAT6 and STAT1 are essential antagonistic regulators of cell survival in classical Hodgkin lymphoma cell line
D Baus, F Nonnenmacher, S Jankowski, C Döring, C Bräutigam, M Frank, M-L Hansmann and E Pfitzner
Leukemia 23: 1885-1893; advance online publication, May 14, 2009; doi:10.1038/leu.2009.103
Myeloma
The effects of JNJ-26481585, a novel hydroxamate-based histone deacetylase inhibitor, on the development of multiple myeloma in the 5T2MM and 5T33MM murine models
S Deleu, M Lemaire, J Arts, E Menu, E Van Valckenborgh, P King, I Vande Broek, H De Raeve, B Van Camp, P Croucher and K Vanderkerken
Leukemia 23: 1894-1903; advance online publication, June 4, 2009; doi:10.1038/leu.2009.121
International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for multiple myeloma and the role of plerixafor (AMD 3100)
S Giralt, E A Stadtmauer, J L Harousseau, A Palumbo, W Bensinger, R L Comenzo, S Kumar, N C Munshi, A Dispenzieri, R Kyle, G Merlini, J San Miguel, H Ludwig, R Hajek, S Jagannath, J Blade, S Lonial, M A Dimopoulos, H Einsele, B Barlogie, K C Anderson, M Gertz, M Attal, P Tosi, P Sonneveld, M Boccadoro, G Morgan, O Sezer, M V Mateos, M Cavo, D Joshua, I Turesson, W Chen, K Shimizu, R Powles, P G Richardson, R Niesvizky, S V Rajkumar and B G M Durie on behalf of the IMWG
Leukemia 23: 1904-1912; advance online publication, June 25, 2009; doi:10.1038/leu.2009.127
Genetic polymorphisms of EPHX1, Gsk3
, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma
B G M Durie, B Van Ness, C Ramos, O Stephens, M Haznadar, A Hoering, J Haessler, M S Katz, G R Mundy, R A Kyle, G J Morgan, J Crowley, B Barlogie and J Shaughnessy Jr
Leukemia 23: 1913-1919; advance online publication, August 6, 2009; doi:10.1038/leu.2009.129
Letters to the Editor
Erythroid/B-cell biphenotypic acute leukemia first case report
J C Lee, S Yang, Y Zou and L Joseph
Leukemia 23: 1920-1923; advance online publication, May 21, 2009; doi:10.1038/leu.2009.105
The 'GGCC' haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera
D Olcaydu, R C Skoda, R Looser, S Li, M Cazzola, D Pietra, F Passamonti, E Lippert, S Carillo, F Girodon, A Vannucchi, N S Reading, J T Prchal, C Ay, I Pabinger, H Gisslinger and R Kralovics
Leukemia 23: 1924-1926; advance online publication, May 14, 2009; doi:10.1038/leu.2009.110
The 1170 A–P single-nucleotide polymorphism (SNP) in the Her-2/neu protein (HER2) as a minor histocompatibility antigen (mHag)
L Wenandy, T Kollgaard, A Letsch, R S Andersen, D Stather, T Seremet, I M Svane, L Vindeløv, M H Andersen and P thor Straten
Leukemia 23: 1926-1929; advance online publication, May 21, 2009; doi:10.1038/leu.2009.112
SNP analyses in cytarabine metabolizing enzymes in AML patients and their impact on treatment response and patient survival: identification of CDA SNP C-451T as an independent prognostic parameter for survival
U Mahlknecht, C-L Dransfeld, N Bulut, M Kramer, C Thiede, G Ehninger and M Schaich
Leukemia 23: 1929-1932; advance online publication, May 21, 2009; doi:10.1038/leu.2009.113
Src family kinase gene targets during myeloid differentiation: identification of the EGR-1 gene as a direct target
J E Jones, L Wang, P L Kropf, R Duan and D E Johnson
Leukemia 23: 1933-1935; advance online publication, June 4, 2009; doi:10.1038/leu.2009.118
B pathways in the M-07e cell line