TABLE OF CONTENTS
Volume 23, Issue 1 (January 2009)
Editorial
The NIH consensus criteria for chronic graft-versus-host disease: far more than just another classification FREE
G Socié
Leukemia 23: 1-2; doi:10.1038/leu.2008.277
Spotlight Reviews
Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma FREE
R A Kyle and S V Rajkumar
Leukemia 23: 3-9; advance online publication, October 30, 2008; doi:10.1038/leu.2008.291
Bone marrow microenvironment and the identification of new targets for myeloma therapy FREE
K Podar, D Chauhan and K C Anderson
Leukemia 23: 10-24; advance online publication, October 9, 2008; doi:10.1038/leu.2008.259
Reviews
Targeting the leukemic stem cell: the Holy Grail of leukemia therapy FREE
N Misaghian, G Ligresti, L S Steelman, F E Bertrand, J Bäsecke, M Libra, F Nicoletti, F Stivala, M Milella, A Tafuri, M Cervello, A M Martelli and J A McCubrey
Leukemia 23: 25-42; advance online publication, September 18, 2008; doi:10.1038/leu.2008.246
CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers FREE
J A Burger and A Peled
Leukemia 23: 43-52; advance online publication, November 6, 2008; doi:10.1038/leu.2008.299
Does chemotherapy modify the immune surveillance of hematological malignancies? FREE
A J Barrett and B N Savani
Leukemia 23: 53-58; advance online publication, October 2, 2008; doi:10.1038/leu.2008.273
Original Articles
Therapy
Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species FREE
E Ortiz-Sánchez, T R Daniels, G Helguera, O Martinez-Maza, B Bonavida, and M L Penichet
Leukemia 23: 59-70; advance online publication, October 23, 2008; doi:10.1038/leu.2008.270
A bispecific single-chain antibody that mediates target cell-restricted, supra-agonistic CD28 stimulation and killing of lymphoma cells FREE
T Otz, L Gro
e-Hovest, M Hofmann, H-G Rammensee and G Jung
Leukemia 23: 71-77; advance online publication, October 2, 2008; doi:10.1038/leu.2008.271
Feasibility of NIH consensus criteria for chronic graft-versus-host disease FREE
B-S Cho, C-K Min, K-S Eom, Y-J Kim, H-J Kim, S Lee, S-G Cho, D-W Kim, J-W Lee, W-S Min and C-C Kim
Leukemia 23: 78-84; advance online publication, October 2, 2008; doi:10.1038/leu.2008.276
Acute Leukemias
Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases FREE
A Murati, C Gervais, N Carbuccia, P Finetti, N Cervera, J Adélaïde, S Struski, E Lippert, F Mugneret, I Tigaud, D Penther, C Bastard, B Poppe, F Speleman, L Baranger, I Luquet, P Cornillet-Lefebvre, N Nadal, F Nguyen-Khac, C Pérot, S Olschwang, F Bertucci, M Chaffanet, M Lessard, M-J Mozziconacci and D Birnbaum on behalf of the Groupe Francophone de Cytogénétique Hématologique (GFCH)
Leukemia 23: 85-94; advance online publication, September 25, 2008; doi:10.1038/leu.2008.257
The key role of stem cell factor/KIT signaling in the proliferation of blast cells from Down syndrome-related leukemia FREE
T Toki, R Kanezaki, S Adachi, H Fujino, G Xu, T Sato, K Suzuki, H Tauchi, M Endo and E Ito
Leukemia 23: 95-103; advance online publication, October 2, 2008; doi:10.1038/leu.2008.267
Asymptomatic kidney stones in long-term survivors of childhood acute lymphoblastic leukemia FREE
S C Kaste, N A Thomas, S N Rai, K Cheon, E McCammon, R Chesney, D Jones, C-H Pui and M M Hudson
Leukemia 23: 104-108; advance online publication, October 2, 2008; doi:10.1038/leu.2008.269
Chronic Myeloproliferative Neoplasias
-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia FREE
Y Hu, Y Chen, L Douglas and S Li
Leukemia 23: 109-116; advance online publication, September 25, 2008; doi:10.1038/leu.2008.262
Chronic Lymphocytic Leukemia
The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype FREE
F Dicker, H Herholz, S Schnittger, A Nakao, N Patten, L Wu, W Kern, T Haferlach and C Haferlach
Leukemia 23: 117-124; advance online publication, October 9, 2008; doi:10.1038/leu.2008.274
Cytogenetics and Molecular Genetics
Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia FREE
C Graux, M Stevens-Kroef, M Lafage, N Dastugue, C J Harrison, F Mugneret, K Bahloula, S Struski, M J Grégoire, N Nadal, E Lippert, S Taviaux, A Simons, R P Kuiper, A V Moorman, K Barber, A Bosly, L Michaux, P Vandenberghe, I Lahortiga, K De Keersmaecker, I Wlodarska, J Cools, A Hagemeijer and H A Poirel on behalf of the GFCH (Groupe Francophone de Cytogénétique Hématologique) and the BCGHO (Belgian Cytogenetic Group for Hematology and Oncology)
Leukemia 23: 125-133; advance online publication, October 16, 2008; doi:10.1038/leu.2008.278
Oncogenes, Fusion Genes and Tumor Suppressor Genes
Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia FREE
K Nebral, D Denk, A Attarbaschi, M König, G Mann, O A Haas and S Strehl
Leukemia 23: 134-143; advance online publication, November 20, 2008; doi:10.1038/leu.2008.306
Transcriptional Control and Signal Transduction
Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage FREE
B da Costa Reis Monte-Mór, I Plo, A F da Cunha, G G L Costa, D M de Albuquerque, A Jedidi, J-L Villeval, S Badaoui, I Lorand-Metze, K B B Pagnano, S T O Saad, W Vainchenker and F F Costa
Leukemia 23: 144-152; advance online publication, October 9, 2008; doi:10.1038/leu.2008.275
Lymphoma
The addition of rituximab to front-line therapy with CHOP (R-CHOP) results in a higher response rate and longer time to treatment failure in patients with lymphoplasmacytic lymphoma: results of a randomized trial of the German Low-Grade Lymphoma Study Group (GLSG) FREE
C Buske, E Hoster, M Dreyling, H Eimermacher, H Wandt, B Metzner, R Fuchs, J Bittenbring, B Woermann, K Hohloch, G Hess, W-D Ludwig, J Schimke, S Schmitz, M Kneba, M Reiser, U Graeven, W Klapper, M Unterhalt and W Hiddemann
Leukemia 23: 153-161; advance online publication, September 25, 2008; doi:10.1038/leu.2008.261
Increased bone marrow microvascular density in haematological malignancies is associated with differential regulation of angiogenic factors FREE
H F S Negaard, N Iversen, I M Bowitz-Lothe, P M Sandset, B Steinsvik, B Østenstad and P O Iversen
Leukemia 23: 162-169; advance online publication, September 18, 2008; doi:10.1038/leu.2008.255
Lymphoma cell adhesion-induced expression of B cell-activating factor of the TNF family in bone marrow stromal cells protects non-Hodgkin's B lymphoma cells from apoptosis FREE
T Lwin, L A Crespo, A Wu, S Dessureault, H B Shu, L C Moscinski, E Sotomayor, W S Dalton and J Tao
Leukemia 23: 170-177; advance online publication, October 9, 2008; doi:10.1038/leu.2008.266
Letters to the Editor
Reply to 'The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rates in hematologic malignancy patients: outcome of a pilot clinical study' by Ning et al. FREE
G Behre, S Theurich, T Weber and M Christopeit
Leukemia 23: 178; advance online publication, June 12, 2008; doi:10.1038/leu.2008.150
Reply to "Reply to 'The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rates in hematologic malignancy patients: outcome of a pilot clinical study' by Ning H et al." by Behre et al. FREE
H Ning, F Yang, M Jiang, L Hu, K Feng, J Zhang, Z Yu, B Li, C Xu, Y Li, J Wang, J Hu, X Lou and H Chen
Leukemia 23: 179-180; advance online publication, June 12, 2008; doi:10.1038/leu.2008.151
5-Azacitidine has limited therapeutic activity in myelofibrosis FREE
R A Mesa, S Verstovsek, C Rivera, A Pardanani, K Hussein, T Lasho, W Wu and A Tefferi
Leukemia 23: 180-182; advance online publication, May 29, 2008; doi:10.1038/leu.2008.136
Improving the prognostic evaluation of patients with lower risk myelodysplastic syndromes FREE
A Kuendgen, N Gattermann and U Germing
Leukemia 23: 182-184; advance online publication, June 12, 2008; doi:10.1038/leu.2008.153
In reply to 'Improving the prognostic evaluation of patients with lower-risk myelodysplastic syndromes' by Kuendgen et al. FREE
G Garcia-Manero
Leukemia 23: 185; advance online publication, June 12, 2008; doi:10.1038/leu.2008.155
MicroRNAs and deletion of the derivative chromosome 9 in chronic myeloid leukemia FREE
A Chaubey, S Karanti, D Rai, T Oh, S G Adhvaryu and R C T Aguiar
Leukemia 23: 186-188; advance online publication, June 12, 2008; doi:10.1038/leu.2008.154
Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo FREE
N Martinez Soria, R Tussiwand, P Ziegler, M G Manz and O Heidenreich
Leukemia 23: 188-190; advance online publication, June 12, 2008; doi:10.1038/leu.2008.157
Prior treatment with the tyrosine kinase inhibitors dasatinib and nilotinib allows stem cell transplantation (SCT) in a less advanced disease phase and does not increase SCT Toxicity in patients with chronic myelogenous leukemia and philadelphia positive acute lymphoblastic leukemia FREE
A Shimoni, M Leiba, M Schleuning, G Martineau, M Renaud, M Koren-Michowitz, E Ribakovski, P le Coutre, R Arnold, F Guilhot and A Nagler
Leukemia 23: 190-194; advance online publication, July 3, 2008; doi:10.1038/leu.2008.160
Reduced intensity conditioning allogeneic stem cell transplantation for patients with acute myeloid leukemia: long term results of a 'donor' versus 'no donor' comparison FREE
M Mohty, H de Lavallade, J El-Cheikh, P Ladaique, C Faucher, S Fürst, N Vey, D Coso, A-M Stoppa, J-A Gastaut, C Chabannon and D Blaise
Leukemia 23: 194-196; advance online publication, June 26, 2008; doi:10.1038/leu.2008.164
Molecular insights into the morphology of myeloproliferative neoplasms using an in situ PCR assay specific for the JAK2 mutation V617F FREE
S Gattenlohner, E Serfling, H Einsele and H K Müller-Hermelink
Leukemia 23: 196-199; advance online publication, June 26, 2008; doi:10.1038/leu.2008.168
Simultaneous occurrence of acute myeloid leukaemia with mutated nucleophosmin (NPM1) in the same family FREE
G Cazzaniga, L Lo Nigro, I Cifola, G Milone, S Schnittger, T Haferlach, E Mirabile, F Costantino, M P Martelli, E Mastrodicasa, F Di Raimondo, F Aversa, A Biondi and B Falini
Leukemia 23: 199-203; advance online publication, July 3, 2008; doi:10.1038/leu.2008.170
TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis FREE
D Bowen, M J Groves, A K Burnett, Y Patel, C Allen, C Green, R E Gale, R Hills and D C Linch on behalf of the Medical Research Council Adult Leukaemia Working Party, UK
Leukemia 23: 203-206; advance online publication, July 3, 2008; doi:10.1038/leu.2008.173
Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling FREE
B A Cardoso, L R Martins, C I Santos, L M Nadler, V A Boussiotis, A A Cardoso and J T Barata
Leukemia 23: 206-208; advance online publication, July 3, 2008; doi:10.1038/leu.2008.178
Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids FREE
G Lönnerholm, A Nordgren, B-M Frost, O G Jonsson, J Kanerva, R Nygaard, K Schmiegelow, R Larsson and E Forestier on behalf of the Nordic Society for Paediatric Haematology and Oncology
Leukemia 23: 209-212; advance online publication, July 10, 2008; doi:10.1038/leu.2008.179
A subset of Binet stage A CLL patients with TP53 abnormalities and mutated IGHV genes have stable disease FREE
O G Best, A C Gardiner, Z A Davis, I Tracy, R E Ibbotson, A Majid, M J S Dyer and D G Oscier
Leukemia 23: 212-214; advance online publication, September 25, 2008; doi:10.1038/leu.2008.260
