Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia

A Corrigendum to this article was published on 10 September 2008

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3

References

  1. Aplan PD, Chervinsky DS, Stanulla M, Burhans WC . Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors. Blood 1996; 87: 2649–2658.

    CAS  PubMed  Google Scholar 

  2. Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 2003; 33: 208–213.

    Article  CAS  PubMed  Google Scholar 

  3. Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T et al. Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). Genes Chromosomes Cancer 2007; 46: 813.

    Article  CAS  PubMed  Google Scholar 

  4. Meyer C, Schneider B, Reichel M, Angermueller S, Strehl S, Schnittger S et al. Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci USA 2005; 102: 449–454.

    Article  CAS  PubMed  Google Scholar 

  5. Whitmarsh RJ, Saginario C, Zhuo Y, Hilgenfeld E, Rappaport EF, Megonigal MD et al. Reciprocal DNA topoisomerase II cleavage events at 5′-TATTA-3′ sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing. Oncogene 2003; 22: 8448–8459.

    Article  CAS  PubMed  Google Scholar 

  6. Radtke F, Wilson A, Mancini SJ, MacDonald HR . Notch regulation of lymphocyte development and function. Nat Immunol 2004; 5: 247–253.

    Article  CAS  Google Scholar 

  7. Ross ME, Zhou X, Song G, Shurtleff SA, Girtman K, Williams WK et al. Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 2003; 102: 2951–2959.

    Article  CAS  PubMed  Google Scholar 

  8. Jankovic V, Ciarrocchi A, Boccuni P, DeBlasio T, Benezra R, Nimer SD . Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells. Proc Natl Acad Sci USA 2007; 104: 1260–1265.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We regret that all colleagues could not be appropriately cited due to the reference limitation. We are thankful to Jörg Meerpohl and Jaroslav Sterba for contributing patient materials and clinical information. Ester Mejstrikova is acknowledged for immunophenotyping, Dana Dvorakova for sample preparation, and Ulla Jacobs and Ines Volkmer for technical assistance. This work was supported by Grants 2002.032.1 from the Wilhelm Sander-Foundation to MM and TL, Grant MSMT21620813 to JZ and JT, Grant N1KR-S12T13 from the BMBF to RM, and Grant 102362 from the Deutsche Krebshilfe to RM.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to M Metzler or R Marschalek.

Additional information

Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Metzler, M., Staege, M., Harder, L. et al. Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia. Leukemia 22, 1807–1811 (2008). https://doi.org/10.1038/leu.2008.50

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2008.50

This article is cited by

Search

Quick links