TABLE OF CONTENTS
Volume 22, Issue 8 (August 2008)
Keynote Address |
Spotlight Reviews |
Review |
Original Articles |
Letters to the Editor |
Corrigenda
Editorial
NG2 antigen is expressed in CD34+ HPCs and plasmacytoid dendritic cell precursors: is NG2 expression in leukemia dependent on the target cell where leukemogenesis is triggered?
C Bueno, R Montes, L Martín, I Prat, M C Hernandez, A Orfao and P Menendez
Leukemia 22: 1475-1478; doi:10.1038/leu.2008.134
Keynote Address
The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement
M A Hussein, F D Vrionis, R Allison, J Berenson, S Berven, E Erdem, S Giralt, S Jagannath, R A Kyle, S LeGrand, R Pflugmacher, N Raje, S V Rajkumar, L Randall, D Roodman, D Siegel, R Vescio, J Zonder and B G M Durie on behalf of the International Myeloma Working Group
Leukemia 22: 1479-1484; advance online publication, May 29, 2008; doi:10.1038/leu.2008.127
Spotlight Reviews
Pathogenesis and treatment of renal failure in multiple myeloma FREE
M A Dimopoulos, E Kastritis, L Rosinol, J Bladé and H Ludwig
Leukemia 22: 1485-1493; advance online publication, June 5, 2008; doi:10.1038/leu.2008.131
Evidence and expertise in the management of polycythemia vera and essential thrombocythemia
G Finazzi and T Barbui
Leukemia 22: 1494-1502; advance online publication, July 3, 2008; doi:10.1038/leu.2008.177
Review
Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: therapeutic potential of cell reprogramming
G Zardo, G Cimino and C Nervi
Leukemia 22: 1503-1518; advance online publication, June 12, 2008; doi:10.1038/leu.2008.141
Original Articles
Therapy
Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16
U Modlich, A Schambach, M H Brugman, D C Wicke, S Knoess, Z Li, T Maetzig, C Rudolph, B Schlegelberger and C Baum
Leukemia 22: 1519-1528; advance online publication, May 22, 2008; doi:10.1038/leu.2008.118
Acute Leukemias
Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia
S-Q Kuang, W-G Tong, H Yang, W Lin, M K Lee, Z H Fang, Y Wei, J Jelinek, J-P Issa and G Garcia-Manero
Leukemia 22: 1529-1538; advance online publication, June 5, 2008; doi:10.1038/leu.2008.130
Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype
C Haferlach, F Dicker, H Herholz, S Schnittger, W Kern and T Haferlach
Leukemia 22: 1539-1541; advance online publication, June 5, 2008; doi:10.1038/leu.2008.143
Chronic Myeloproliferative Disorders
Identification of NM23-H2 as a tumour-associated antigen in chronic myeloid leukaemia
S Tschiedel, C Gentilini, T Lange, C Wölfel, T Wölfel, V Lennerz, S Stevanovic, H-G Rammensee, C Huber, M Cross and D Niederwieser
Leukemia 22: 1542-1550; advance online publication, May 22, 2008; doi:10.1038/leu.2008.107
Familial essential thrombocythemia with spontaneous megakaryocyte colony formation and acquired JAK2 mutations
J R Higgs, I Sadek, P E Neumann, V W Ing, N K Renault, J N Berman and W L Greer
Leukemia 22: 1551-1556; advance online publication, May 22, 2008; doi:10.1038/leu.2008.115
New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition
R Chaligné, C Tonetti, R Besancenot, L Roy, C Marty, P Mossuz, J-J Kiladjian, G Socié, D Bordessoule, M-C Le Bousse-Kerdilès, W Vainchenker and S Giraudier
Leukemia 22: 1557-1566; advance online publication, June 5, 2008; doi:10.1038/leu.2008.137
Cytogenetics and Molecular Genetics
Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: an integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogénétique hématologique
C Gervais, A Murati, C Helias, S Struski, A Eischen, E Lippert, I Tigaud, D Penther, C Bastard, F Mugneret, B Poppe, F Speleman, P Talmant, J VanDen Akker, L Baranger, C Barin, I Luquet, N Nadal, F Nguyen-Khac, O Maarek, C Herens, D Sainty, G Flandrin, D Birnbaum, M-J Mozziconacci and M Lessard
Leukemia 22: 1567-1575; advance online publication, June 5, 2008; doi:10.1038/leu.2008.128
Sensitivity and Resistance to Therapy
Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration
B Chapuy, R Koch, U Radunski, S Corsham, N Cheong, N Inagaki, N Ban, D Wenzel, D Reinhardt, A Zapf, S Schweyer, F Kosari, W Klapper, L Truemper and G G Wulf
Leukemia 22: 1576-1586; advance online publication, May 8, 2008; doi:10.1038/leu.2008.103
Lymphoma
Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma
F Jundt, Ö Acikgöz, S-H Kwon, R Schwarzer, I Anagnostopoulos, B Wiesner, S Mathas, M Hummel, H Stein, H M Reichardt and B Dörken
Leukemia 22: 1587-1594; advance online publication, May 1, 2008; doi:10.1038/leu.2008.101
Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK+ anaplastic large cell lymphoma
J Dien Bard, P Gelebart, M Anand, H M Amin and R Lai
Leukemia 22: 1595-1603; advance online publication, May 29, 2008; doi:10.1038/leu.2008.129
Myeloma
Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma
T Stühmer, A Zöllinger, D Siegmund, M Chatterjee, E Grella, S Knop, M Kortüm, C Unzicker, M R Jensen, C Quadt, P Chène, J Schoepfer, C García-Echeverría, H Einsele, H Wajant and R C Bargou
Leukemia 22: 1604-1612; advance online publication, May 15, 2008; doi:10.1038/leu.2008.111
Letters to the Editor
A pilot vaccination trial of synthetic analog peptides derived from the BCR-ABL breakpoints in CML patients with minimal disease
P G Maslak, T Dao, M Gomez, S Chanel, J Packin, T Korontsvit, V Zakhaleva, J Pinilla-Ibarz, E Berman and D A Scheinberg
Leukemia 22: 1613-1616; advance online publication, February 7, 2008; doi:10.1038/leu.2008.7
Long-term molecular complete remission with IFN-
in Ph+ adult acute lymphoid leukemia patients
P P Piccaluga, G Martinelli, A Isidori, M Malagola, M Rondoni, S Paolini, M Amabile, I Iacobucci, M Baccarani and G Visani
Leukemia 22: 1617-1618; advance online publication, February 14, 2008; doi:10.1038/leu.2008.10
Successful peripheral blood stem cell mobilization with granulocyte colony-stimulating factor in a patient with chronic myeloid leukemia achieving a complete cytogenetic remission with dasatinib after failing imatinib
I Gabriel, A Chaidos, J Sorouri, E Dannie, J Davis, J Goldman, J Apperley and D Marin
Leukemia 22: 1618-1619; advance online publication, February 28, 2008; doi:10.1038/leu.2008.13
BRAF mutations are very rare in B- and T-cell pediatric acute lymphoblastic leukemias
J Davidsson, H Lilljebjörn, I Panagopoulos, T Fioretos and B Johansson
Leukemia 22: 1619-1621; advance online publication, February 14, 2008; doi:10.1038/leu.2008.14
Splenic marginal zone lymphomas and lymphoplasmacytic lymphomas originate from B-cell compartments with two different antigen-exposure histories
M Parrens, N Gachard, B Petit, A Marfak, E Troadec, K Bouabdhalla, N Milpied, J P Merlio, A de Mascarel, C Laurent, I Soubeyran, V Coste, F Labrousse, M Cogné and J Feuillard
Leukemia 22: 1621-1624; advance online publication, February 28, 2008; doi:10.1038/leu.2008.24
Gefitinib potentiates myeloid cell differentiation by ATRA
M B Miranda, R Duan, S M Thomas, J R Grandis, R L Redner, J E Jones and D E Johnson
Leukemia 22: 1624-1627; advance online publication, February 28, 2008; doi:10.1038/leu.2008.28
The feasibility of using topotecan, vinorelbine, thiotepa and gemcitabine (TVTG) in adult patients with relapsed/refractory acute lymphoblastic leukaemia/lymphoma
P Hiwarkar, H-T Arkenau, J Treleaven, G Morgan, M Potter and M Ethell
Leukemia 22: 1627-1629; advance online publication, February 28, 2008; doi:10.1038/leu.2008.31
Lack of association of the heparanase gene single-nucleotide polymorphism Arg307Lys with acute lymphoblastic leukaemia in patients from Northern Ireland
P C Winter, M F McMullin and M A Catherwood
Leukemia 22: 1629-1631; advance online publication, February 28, 2008; doi:10.1038/leu.2008.36
Reply to 'Lack of association of the heparanase gene single-nucleotide polymorphism Arg307Lys with acute lymphoblastic leukemia in patients from Northern Ireland' by Winter et al.
O Ostrovsky, M Korostishevsky and A Nagler
Leukemia 22: 1631; advance online publication, February 28, 2008; doi:10.1038/leu.2008.37
Reply to Ostrovosky et al.
P C Winter, M F McMullin and M A Catherwood
Leukemia 22: 1632; advance online publication, February 28, 2008; doi:10.1038/leu.2008.38
Reply to Winter et al.
O Ostrovsky, M Korostishevsky and A Nagler
Leukemia 22: 1632-1633; advance online publication, February 28, 2008; doi:10.1038/leu.2008.39
Making progress in treating multiple myeloma with total therapies: issue of complete remission and more
B Barlogie, F van Rhee, J D Shaughnessy Jr, E Anaissie and J Crowley
Leukemia 22: 1633-1636; advance online publication, February 28, 2008; doi:10.1038/leu.2008.40
Bortezomib therapy in myelofibrosis: a phase II clinical trial
R A Mesa, S Verstovsek, C Rivera, A Pardanani, K Hussein, T Lasho, W Wu and A Tefferi
Leukemia 22: 1636-1638; advance online publication, February 28, 2008; doi:10.1038/leu.2008.32
What do we mean by sensitivity when we talk about detecting minimal residual disease?
D Steinbach and K-M Debatin
Leukemia 22: 1638-1639; advance online publication, February 28, 2008; doi:10.1038/leu.2008.33
ETV6 mutations and loss in AML-M0
F P G Silva, B Morolli, C T Storlazzi, A Zagaria, L Impera, B Klein, H Vrieling, H C Kluin-Nelemans and M Giphart-Gassler
Leukemia 22: 1639-1643; advance online publication, February 28, 2008; doi:10.1038/leu.2008.34
Low frequency of the glutathione-S-transferase T1-null genotype in patients with primary myelodysplastic syndrome and 5q deletion
C Stavropoulou, C Sambani, H Rigana, V N Georgakakos, G Voutsinas, K N Manola, G E Pantelias and V Makropoulos the Hellenic MDS Study Group
Leukemia 22: 1643-1646; advance online publication, February 28, 2008; doi:10.1038/leu.2008.35
MAGE-C1/CT7 is the dominant cancer-testis antigen targeted by humoral immune responses in patients with multiple myeloma
A Curioni-Fontecedro, A J Knights, M Tinguely, N Nuber, C Schneider, C W Thomson, L von Boehmer, W Bossart, S Pahlich, H Gehring, H Moch, C Renner, A Knuth and A Zippelius
Leukemia 22: 1646-1648; advance online publication, March 6, 2008; doi:10.1038/leu.2008.43
Corrigenda
The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement FREE
M A Hussein, F D Vrionis, R Allison, J Berenson, S Berven, E Erdem, S Giralt, S Jagannath, R A Kyle, S LeGrand, R Pflugmacher, N Raje, S V Rajkumar, R L Randall, D Roodman, D Siegel, R Vescio, J Zonder and B G M Durie on behalf of the International Myeloma Working Group
Leukemia 22: 1649; doi:10.1038/leu.2008.181
