TABLE 1
FROM:
Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia
P D Emanuel
BACK TO ARTICLETable 1. Diagnostic criteria for CMML and JMML
| WHO diagnostic criteria for CMML6 | 1. Persistent peripheral blood monocytosis (>1  109/l)2. No Philadelphia chromosome or BCR-ABL fusion gene 3. <20% myeloblasts or monoblasts in the peripheral blood or marrow 4. Evidence of dysplasia in one or more myeloid lineages |
| If evidence of dysplasia is absent or minimal, there are alternatives for WHO CMML diagnostic criteria | (a) An acquired, clonal cytogenetic abnormality in marrow cells (b) Persistent monocytosis for more than 3 months (c) All other causes of monocytosis have been excluded |
| WHO subcategories of CMML | CMML-1 5% blasts in the blood and <10% blasts in the marrowCMML-2=5–19% blasts in the blood and 10–19% blasts in the marrow |
| Minimal Diagnostic Criteria for JMML (adopted by the International JMML Working Group and by EWOG-MDS)17 | Suggestive clinical features: Hepatosplenomegaly Lymphadenopathy Pallor Fever Skin Rash |
| Laboratory criteria (all three must be met): 1. Persistent peripheral blood monocytosis (>1 109/l)2. No Philadelphia chromosome or BCR–ABL fusion gene 3. <20% myeloblasts or monoblasts in the marrow | |
| Further criteria to be met (need to fulfill at least two): 1. Increased hemoglobin F (corrected for age) 2. Immature myeloid precursors on the peripheral blood smear 3. Peripheral blood white blood cell count >1 1010/l4. Clonal cytogenetic abnormalities (including monosomy 7) 5. GM-CSF hypersensitivity of myeloid progenitors (in vitro test) |
