TABLE OF CONTENTS
Volume 22, Issue 6 (June 2008)
Editorial
Globalization of treatment strategies in leukemia: challenges and responsibilities
A Tefferi and N M-B Killmann
Leukemia 22: 1093-1094; doi:10.1038/leu.2008.132
Review
MicroRNAs and noncoding RNAs in hematological malignancies: molecular, clinical and therapeutic implications
M Fabbri, R Garzon, M Andreeff, H M Kantarjian, G Garcia-Manero and G A Calin
Leukemia 22: 1095-1105; advance online publication, March 6, 2008; doi:10.1038/leu.2008.30
Original Articles
Molecular Targets for Therapy
The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism
F Chiarini, M Del Sole, S Mongiorgi, G C Gaboardi, A Cappellini, I Mantovani, M Y Follo, J A McCubrey and A M Martelli
Leukemia 22: 1106-1116; advance online publication, April 3, 2008; doi:10.1038/leu.2008.79
Activity of tyrosine kinase inhibitors against human NUP214-ABL1-positive T cell malignancies
A Quintás-Cardama, W Tong, T Manshouri, F Vega, P A Lennon, J Cools, D G Gilliland, F Lee, J Cortes, H Kantarjian and G Garcia-Manero
Leukemia 22: 1117-1124; advance online publication, April 10, 2008; doi:10.1038/leu.2008.80
Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia
A Habib, E Hamade, R Mahfouz, M S Nasrallah, H de Thé and A Bazarbachi
Leukemia 22: 1125-1130; advance online publication, March 20, 2008; doi:10.1038/leu.2008.59
RNAi-mediated silencing of p190Bcr-Abl inactivates Stat5 and cooperates with imatinib mesylate and 17-allylamino-17-demetoxygeldanamycin in selective killing of p190Bcr-Abl-expressing leukemia cells
M Futami, T Hatano, Y Soda, S Kobayashi, M Miyagishi and A Tojo
Leukemia 22: 1131-1138; advance online publication, March 27, 2008; doi:10.1038/leu.2008.60
Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas
A L Feldman, D X Sun, M E Law, A J Novak, A D Attygalle, E C Thorland, S R Fink, J A Vrana, B L Caron, W G Morice, E D Remstein, K L Grogg, P J Kurtin, W R Macon and A Dogan
Leukemia 22: 1139-1143; advance online publication, April 10, 2008; doi:10.1038/leu.2008.77
Therapy
Results of the first randomized multicentre trial on childhood acute lymphoblastic leukaemia in Russia
A Karachunskiy, R Herold, A von Stackelberg, N Miakova, A Timakow, T Mahortih, L Bajdun, A Maschan, L Fechina, A Shamardina, S Dudkin, V Lebedev, S Varfolomeeva, V Timofeeva, J Roumiantseva, N Chipsanova, A Rumjanzew and G Henze
Leukemia 22: 1144-1153; advance online publication, March 27, 2008; doi:10.1038/leu.2008.63
Acute Leukemias
Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group
U Baak, N Gökbuget, H Orawa, S Schwartz, D Hoelzer, E Thiel and T Burmeister
Leukemia 22: 1154-1160; advance online publication, March 27, 2008; doi:10.1038/leu.2008.52
HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia
J T Whelan, D L Ludwig and F E Bertrand
Leukemia 22: 1161-1169; advance online publication, March 13, 2008; doi:10.1038/leu.2008.57
Myelodysplasias
T-cell receptor V
CDR3 oligoclonality frequently occurs in childhood refractory cytopenia (MDS-RC) and severe aplastic anemia
A C H de Vries, A W Langerak, B Verhaaf, C M Niemeyer, J Stary, K Schmiegelow, E R van Wering, C M Zwaan, A Beishuizen, R Pieters and M M van den Heuvel-Eibrink
Leukemia 22: 1170-1174; advance online publication, March 6, 2008; doi:10.1038/leu.2008.23
The immunophenotype of different immature, myeloid and B-cell lineage-committed CD34+ hematopoietic cells allows discrimination between normal/reactive and myelodysplastic syndrome precursors
S Matarraz, A López, S Barrena, C Fernandez, E Jensen, J Flores, P Bárcena, A Rasillo, J M Sayagues, M L Sánchez, P Hernandez-Campo, J M Hernandez Rivas, C Salvador, N Fernandez-Mosteirín, M Giralt, L Perdiguer and A Orfao
Leukemia 22: 1175-1183; advance online publication, March 13, 2008; doi:10.1038/leu.2008.49
Chronic Myeloproliferative Disorders
Characterization of BCR-ABL deletion mutants from patients with chronic myeloid leukemia
D W Sherbenou, O Hantschel, L Turaga, I Kaupe, S Willis, T Bumm, R D Press, G Superti-Furga, B J Druker and M W Deininger
Leukemia 22: 1184-1190; advance online publication, March 20, 2008; doi:10.1038/leu.2008.65
Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism
H Zhang, D Trachootham, W Lu, J Carew, F J Giles, M J Keating, R B Arlinghaus and P Huang
Leukemia 22: 1191-1199; advance online publication, April 3, 2008; doi:10.1038/leu.2008.74
Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib
A Hochhaus, M Baccarani, M Deininger, J F Apperley, J H Lipton, S L Goldberg, S Corm, N P Shah, F Cervantes, R T Silver, D Niederwieser, R M Stone, H Dombret, R A Larson, L Roy, T Hughes, M C Müller, R Ezzeddine, A M Countouriotis and H M Kantarjian
Leukemia 22: 1200-1206; advance online publication, April 10, 2008; doi:10.1038/leu.2008.84
Stem Cells
CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL
Y Kong, S Yoshida, Y Saito, T Doi, Y Nagatoshi, M Fukata, N Saito, S M Yang, C Iwamoto, J Okamura, K Y Liu, X J Huang, D P Lu, L D Shultz, M Harada and F Ishikawa
Leukemia 22: 1207-1213; advance online publication, April 17, 2008; doi:10.1038/leu.2008.83
Normal Hemopoiesis
Dose-dependent repression of T-cell and natural killer cell genes by PU.1 enforces myeloid and B-cell identity
M B Kamath, I B Houston, A J Janovski, X Zhu, S Gowrisankar, A G Jegga and R P DeKoter
Leukemia 22: 1214-1225; advance online publication, March 20, 2008; doi:10.1038/leu.2008.67
Immunology
Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation
W Zhao, Y H Gu, R Song, B Q Qu and Q Xu
Leukemia 22: 1226-1233; advance online publication, March 13, 2008; doi:10.1038/leu.2008.58
Sensitivity and Resistance to Therapy
Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-
B in AML carrying NPM1 mutations
D Cilloni, F Messa, V Rosso, F Arruga, I Defilippi, S Carturan, R Catalano, M Pautasso, C Panuzzo, P Nicoli, E Messa, A Morotti, I Iacobucci, G Martinelli, E Bracco and G Saglio
Leukemia 22: 1234-1240; advance online publication, April 10, 2008; doi:10.1038/leu.2008.68
Oncogenes, Fusion Genes and Tumor Suppressor Genes
AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1
M Takeshita, M Ichikawa, E Nitta, S Goyama, T Asai, S Ogawa, S Chiba and M Kurokawa
Leukemia 22: 1241-1249; advance online publication, March 13, 2008; doi:10.1038/leu.2008.53
Myeloma
Impact of genetic abnormalities on survival after allogeneic hematopoietic stem cell transplantation in multiple myeloma
G Schilling, T Hansen, A Shimoni, T Zabelina, J-A Simon-Perez, N C Gutierrez, W Bethge, P Liebisch, R Schwerdtfeger, M Bornhäuser, S Otterstetter, E M M Penas, J Dierlamm, F Ayuk, D Atanackovic, U Bacher, C Bokemeyer, A Zander, J S Miguel, A Nagler and N Kröger
Leukemia 22: 1250-1255; advance online publication, April 17, 2008; doi:10.1038/leu.2008.88
Letters to the Editor
Third party mesenchymal stromal cell infusions fail to induce tissue repair despite successful control of severe grade IV acute graft-versus-host disease in a child with juvenile myelo-monocytic leukemia
L Ball, R Bredius, A Lankester, J Schweizer, M van den Heuvel-Eibrink, H Escher, W Fibbe and M Egeler
Leukemia 22: 1256-1257; advance online publication, November 1, 2007; doi:10.1038/sj.leu.2405013
Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells
G Kong, D Wang, H Wang, J Wu, J Bielawski, M Konopleva, M Andreeff, P P Ruvolo and B J Maurer
Leukemia 22: 1258-1262; advance online publication, November 22, 2007; doi:10.1038/sj.leu.2405023
t(3;7)(q27;q32) fuses BCL6 to a non-coding region at FRA7H near miR-29
B Schneider, S Nagel, M Kaufmann, S Winkelmann, J Bode, H G Drexler and R A F MacLeod
Leukemia 22: 1262-1266; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405025
BMI1 as oncogenic candidate in a novel TCRB-associated chromosomal aberration in a patient with TCR
+ T-cell acute lymphoblastic leukemia
N S D Larmonie, W A Dik, H B Beverloo, E R van Wering, J J M van Dongen and A W Langerak
Leukemia 22: 1266-1267; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405026
The prevalence of IG translocations and 7q32 deletions in splenic marginal zone lymphoma
E D Remstein, M Law, M Mollejo, M A Piris, P J Kurtin and A Dogan
Leukemia 22: 1268-1272; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405027
Treatment of relapsed acute myeloid leukemia with MLL/AF6 fusion after allogeneic hematopoietic stem cell transplantation with gemtuzumab ozogamicin with a long interval followed by donor lymphocyte infusion
H Tamai, Y Shioi, H Yamaguchi, M Okabe, S Wakita, T Mizuki, K Nakayama, K Inokuchi, K Tajika and K Dan
Leukemia 22: 1273-1274; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405029
MicroRNA expression profiles of human leukemias
S Takada, Y Yamashita, E Berezikov, H Hatanaka, S-i Fujiwara, K Kurashina, H Watanabe, M Enomoto, M Soda, Y L Choi and H Mano
Leukemia 22: 1274-1278; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405031
Fusion of ZMIZ1 to ABL1 in a B-cell acute lymphoblastic leukaemia with a t(9;10)(q34;q22.3) translocation
G Soler, I Radford-Weiss, R Ben-abdelali, N Mahlaoui, J F Ponceau, E A Macintyre, M Vekemans, O A Bernard and S P Romana
Leukemia 22: 1278-1280; advance online publication, November 15, 2007; doi:10.1038/sj.leu.2405033
Effect of lenalidomide therapy on mobilization of peripheral blood stem cells in previously untreated multiple myeloma patients
A Mazumder, J Kaufman, R Niesvizky, S Lonial, D Vesole and S Jagannath
Leukemia 22: 1280-1281; advance online publication, November 22, 2007; doi:10.1038/sj.leu.2405035
Reply to 'Effect of lenalidomide therapy on mobilization of peripheral blood stem cells in previously untreated multiple myeloma patients'
S Kumar and M A Gertz
Leukemia 22: 1281-1282; advance online publication, November 22, 2007; doi:10.1038/sj.leu.2405036
Compromised stem cell mobilization following induction therapy with lenalidomide in myeloma
H Paripati, A K Stewart, S Cabou, A Dueck, V J Zepeda, N Pirooz, C Ehlenbeck, C Reeder, J Slack, J F Leis, J Boesiger, A S Torloni, R Fonseca and P L Bergsagel
Leukemia 22: 1282-1284; advance online publication, January 24, 2008; doi:10.1038/sj.leu.2405100
Use of pegylated recombinant filgrastim (Pegfilgrastim) in patients with acute myeloid leukemia: pharmacokinetics and impact on leukocyte recovery
M Fiegl, W Hiddemann and J Braess
Leukemia 22: 1284-1285; advance online publication, November 22, 2007; doi:10.1038/sj.leu.2405038
In human genome, generation of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML
A Liso, A Bogliolo, V Freschi, M P Martelli, S A Pileri, M Santodirocco, N Bolli, M F Martelli and B Falini
Leukemia 22: 1285-1289; advance online publication, December 6, 2007; doi:10.1038/sj.leu.2405045
JAK2 Mutations are present in all cases of polycythemia vera
Y L Wang, K Vandris, A Jones, N C P Cross, P Christos, F Adriano and R T Silver
Leukemia 22: 1289; advance online publication, December 13, 2007; doi:10.1038/sj.leu.2405047
Fresh frozen plasma contains free asparagine and may replace the plasma asparagine pool during L-asparaginase therapy
M Steiner, A Attarbaschi, O A Haas, U Kastner, H Gadner and G Mann
Leukemia 22: 1290; advance online publication, November 29, 2007; doi:10.1038/sj.leu.2405051
Low MCL-1 mRNA expression correlates with prolonged survival in B-cell chronic lymphocytic leukemia
L Véronèse, O Tournilhac, P Verrelle, F Davi, G Dighiero, E Chautard, R Veyrat-Masson, F Kwiatkowski, C Goumy, P Vago, P Travade and A Tchirkov
Leukemia 22: 1291-1293; advance online publication, November 29, 2007; doi:10.1038/sj.leu.2405052
Methylation analysis of the von Hippel-Lindau gene in acute myeloid leukaemia and myelodysplastic syndromes
L Benetatos, A Dasoula, N Syed, E Hatzimichael, T Crook and K L Bourantas
Leukemia 22: 1293-1295; advance online publication, December 20, 2007; doi:10.1038/sj.leu.2405053
Prognostic interaction between thrombocytosis and JAK2 V617F mutation in the WHO subcategories of myelodysplastic/myeloproliferative disease-unclassifiable and refractory anemia with ringed sideroblasts and marked thrombocytosis
E Atallah, R Nussenzveig, C C Yin, C Bueso-Ramos, C Tam, T Manshouri, S Pierce, H Kantarjian and S Verstovsek
Leukemia 22: 1295-1298; advance online publication, December 6, 2007; doi:10.1038/sj.leu.2405054
