TABLE OF CONTENTS
Volume 22, Issue 3 (March 2008)
Editorial
Mesenchymal stem cells for graft-versus-host disease: a double edged sword?
F Vianello and F Dazzi
Leukemia 22: 463-465; doi:10.1038/leu.2008.25
Spotlight Reviews
Chemokine-mobilized adult stem cells; defining a better hematopoietic graft
L M Pelus and S Fukuda
Leukemia 22: 466-473; advance online publication, November 1, 2007; doi:10.1038/sj.leu.2405021
Choosing between stem cell therapy and drugs in myelofibrosis
N Kröger and R A Mesa
Leukemia 22: 474-486; advance online publication, January 10, 2008; doi:10.1038/sj.leu.2405080
Review
Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria
E Matutes, D Oscier, C Montalban, F Berger, E Callet-Bauchu, A Dogan, P Felman, V Franco, E Iannitto, M Mollejo, T Papadaki, E D Remstein, A Salar, F Solé, K Stamatopoulos, C Thieblemont, A Traverse-Glehen, A Wotherspoon, B Coiffier and M A Piris
Leukemia 22: 487-495; advance online publication, December 20, 2007; doi:10.1038/sj.leu.2405068
Original Articles
Infectious Medicine
Novel antifungal agents as salvage therapy for invasive aspergillosis in patients with hematologic malignancies: posaconazole compared with high-dose lipid formulations of amphotericin B alone or in combination with caspofungin
I I Raad, H A Hanna, M Boktour, Y Jiang, H A Torres, C Afif, D P Kontoyiannis and R Y Hachem
Leukemia 22: 496-503; advance online publication, December 20, 2007; doi:10.1038/sj.leu.2405065
Acute Leukemias
Bone marrow fibrosis in childhood acute lymphoblastic leukemia correlates to biological factors, treatment response and outcome
U Norén-Nyström, G Roos, A Bergh, J Botling, G Lönnerholm, A Porwit, M Heyman and E Forestier
Leukemia 22: 504-510; advance online publication, December 20, 2007; doi:10.1038/sj.leu.2405072
Re-expression of DNA methylation-silenced CD44 gene in a resistant NB4 cell line: rescue of CD44-dependent cell death by cAMP
I Abecassis, J Maes, J-L Carrier, J Hillion, M Goodhardt, K Medjber, L Wany, M Lanotte and A Karniguian
Leukemia 22: 511-520; advance online publication, December 20, 2007; doi:10.1038/sj.leu.2405071
The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy
Y Ge, K M LaFiura, A A Dombkowski, Q Chen, S G Payton, S A Buck, S Salagrama, A E Diakiw, L H Matherly and J W Taub
Leukemia 22: 521-529; advance online publication, December 20, 2007; doi:10.1038/sj.leu.2405066
Myelodysplasias
Immunophenotypic, cytogenetic and functional characterization of circulating endothelial cells in myelodysplastic syndromes
M G Della Porta, L Malcovati, G M Rigolin, V Rosti, E Bonetti, E Travaglino, E Boveri, A Gallì, S Boggi, M Ciccone, T Pramparo, G Mazzini, R Invernizzi, M Lazzarino and M Cazzola
Leukemia 22: 530-537; advance online publication, December 20, 2007; doi:10.1038/sj.leu.2405069
A prognostic score for patients with lower risk myelodysplastic syndrome
G Garcia-Manero, J Shan, S Faderl, J Cortes, F Ravandi, G Borthakur, W G Wierda, S Pierce, E Estey, J Liu, X Huang and H Kantarjian
Leukemia 22: 538-543; advance online publication, December 13, 2007; doi:10.1038/sj.leu.2405070
Comparison of hypoplastic myelodysplastic syndrome (MDS) with normo-/hypercellular MDS by International Prognostic Scoring System, cytogenetic and genetic studies
T-C Huang, B-S Ko, J-L Tang, C Hsu, C-Y Chen, W Tsay, S-Y Huang, M Yao, Y-C Chen, M-C Shen, C-H Wang and H-F Tien
Leukemia 22: 544-550; advance online publication, December 20, 2007; doi:10.1038/sj.leu.2405076
Base excision repair dysfunction in a subgroup of patients with myelodysplastic syndrome
A M Jankowska, L P Gondek, H Szpurka, Z P Nearman, R V Tiu and J P Maciejewski
Leukemia 22: 551-558; advance online publication, December 6, 2007; doi:10.1038/sj.leu.2405055
Chronic Myeloproliferative Disorders
Subcellular distribution of p210BCR-ABL in CML cell lines and primary CD34+ CML cells
H Patel, S B Marley, L Greener and M Y Gordon
Leukemia 22: 559-571; advance online publication, December 6, 2007; doi:10.1038/sj.leu.2405057
Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070
S Dong, S Kang, S Lonial, H J Khoury, J Viallet and J Chen
Leukemia 22: 572-577; advance online publication, December 13, 2007; doi:10.1038/sj.leu.2405064
HLA-G turns off erythropoietin receptor signaling through JAK2 and JAK2 V617F dephosphorylation: clinical relevance in polycythemia vera
C Menier, C Guillard, B Cassinat, E D Carosella and N Rouas-Freiss
Leukemia 22: 578-584; advance online publication, December 6, 2007; doi:10.1038/sj.leu.2405050
Chronic Lymphocytic Leukemia
Targeting lipid metabolism by the lipoprotein lipase inhibitor orlistat results in apoptosis of B-cell chronic lymphocytic leukemia cells
C P Pallasch, J Schwamb, S Königs, A Schulz, S Debey, D Kofler, J L Schultze, M Hallek, A Ultsch and C-M Wendtner
Leukemia 22: 585-592; advance online publication, December 13, 2007; doi:10.1038/sj.leu.2405058
Stem Cells
The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study
H Ning, F Yang, M Jiang, L Hu, K Feng, J Zhang, Z Yu, B Li, C Xu, Y Li, J Wang, J Hu, X Lou and H Chen
Leukemia 22: 593-599; advance online publication, January 10, 2008; doi:10.1038/sj.leu.2405090
Cytogenetics and Molecular Genetics
MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines
S Nagel, C Meyer, H Quentmeier, M Kaufmann, H G Drexler and R A F MacLeod
Leukemia 22: 600-607; advance online publication, December 13, 2007; doi:10.1038/sj.leu.2405067
Animal Models
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus
T J Hagenbeek and H Spits
Leukemia 22: 608-619; advance online publication, November 29, 2007; doi:10.1038/sj.leu.2405056
Lymphoma
Cell origin of pyothorax-associated lymphoma: a lymphoma strongly associated with Epstein–Barr virus infection
T Takakuwa, K Tresnasari, N Rahadiani, H Miwa, M Daibata and K Aozasa
Leukemia 22: 620-627; advance online publication, December 13, 2007; doi:10.1038/sj.leu.2405059
Letters to the Editor
Vorinostat and bortezomib significantly inhibit WT1 gene expression in MO7-e and P39 cell lines
S Galimberti, M Canestraro, R Khan, G Buda, E Orciuolo, F Guerrini, R Fazzi, R Maffei, R Marasca and M Petrini
Leukemia 22: 628-631; advance online publication, August 30, 2007; doi:10.1038/sj.leu.2404918
Platelet transfusion and survival in adults with acute leukemia
N Blumberg, J M Heal, J L Liesveld, G L Phillips and J M Rowe
Leukemia 22: 631-635; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404920
The immunomodulatory drug Leflunomide inhibits cell cycle progression of B-CLL cells
I Ringshausen, M Oelsner, C Bogner, C Peschel and T Decker
Leukemia 22: 635-638; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404922
Chromosomal localization of DNA methylation in small B-cell lymphoma
K H Taylor, F Rahmatpanah, J W Davis and C W Caldwell
Leukemia 22: 638-641; advance online publication, August 30, 2007; doi:10.1038/sj.leu.2404921
Non-specific amplification of patient-specific Ig/TCR gene rearrangements depends on the time point during therapy: implications for minimal residual disease monitoring
V H J van der Velden, J M Wijkhuijs and J J M van Dongen
Leukemia 22: 641-644; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404925
A novel cytogenetic aberration found in stem cell leukemia/lymphoma syndrome
L Shvidel, E Sigler, E Vorst, E Feldberg, N Voskoboinic, M Shtalrid and A Berrebi
Leukemia 22: 644-646; advance online publication, October 11, 2007; doi:10.1038/sj.leu.2404942
Pulmonary arterial hypertension in primary myelofibrosis is common and associated with an altered angiogenic status
A Cortelezzi, G Gritti, N Del Papa, M C Pasquini, R Calori, U Gianelli, M Cortiana, G Parati, F Onida, F Sozzi, C Vener, P Bianchi and G L Deliliers
Leukemia 22: 646-649; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404943
Comparison of nilotinib and imatinib inhibition of FMS receptor signaling, macrophage production and osteoclastogenesis
N Brownlow, A E Russell, H Saravanapavan, M Wiesmann, J M Murray, P W Manley and N J Dibb
Leukemia 22: 649-652; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404944
Acute myeloid leukemia-targeted toxins kill tumor cells by cell type-specific mechanisms and synergize with TRAIL to allow manipulation of the extent and mechanism of tumor cell death
H Horita, A E Frankel and A Thorburn
Leukemia 22: 652-655; advance online publication, September 20, 2007; doi:10.1038/sj.leu.2404956
Recurrent in-frame insertion in C/EBP
TAD2 region is a polymorphism without prognostic value in AML
V Biggio, A Renneville, O Nibourel, N Philippe, L Terriou, C Roumier, P Amouyel, D Cottel, S Castaigne, H Dombret, X Thomas, P Fenaux and C Preudhomme A study from the French alfa group
Leukemia 22: 655-657; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404926
Multiple forms of nuclear p53 formed in human Raji and MEC1 cells treated with fludarabine
S Henrich and R I Christopherson
Leukemia 22: 657-660; advance online publication, August 30, 2007; doi:10.1038/sj.leu.2404929
MassARRAY assay: a more accurate method for JAK2V617F mutation detection in Chinese patients with myeloproliferative disorders
J-F Fu, J-Y Shi, W-L Zhao, G Li, Q Pan, J-M Li, J Hu, Z-X Shen, J Jin, F-Y Chen and S-J Chen
Leukemia 22: 660-663; advance online publication, August 30, 2007; doi:10.1038/sj.leu.2404931
NCOA3, a new fusion partner for MOZ/MYST3 in M5 acute myeloid leukemia
S Esteyries, C Perot, J Adelaide, M Imbert, A Lagarde, C Pautas, S Olschwang, D Birnbaum, M Chaffanet and M-J Mozziconacci
Leukemia 22: 663-665; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404930
CREB regulates Meis1 expression in normal and malignant hematopoietic cells
S D Esparza, J Chang, D B Shankar, B Zhang, S F Nelson and K M Sakamoto
Leukemia 22: 665-667; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404933
Mcl-1 and anticancer vaccination: identification of an HLA-A2-restricted epitope
R S Andersen, L Wenandy, R B Sørensen, P thor Straten and M H Andersen
Leukemia 22: 668-669; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404937
No role for CXCL12–G801A polymorphism in the development of extramedullary disease in acute myeloid leukemia
V Ponziani, F Mannelli, N Bartalucci, G Gianfaldoni, F Leoni, E Antonioli, P Guglielmelli, S Ciolli, A Bosi and A M Vannucchi
Leukemia 22: 669-671; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404938