TABLE OF CONTENTS
Volume 22, Issue 2 (February 2008)
Leading Article
Clinically relevant end points and new drug approvals for myeloma
K C Anderson, R A Kyle, S V Rajkumar, A K Stewart, D Weber and P Richardson on behalf of the ASHTM /FDA Panel on Clinical Endpoints in Multiple Myeloma
Leukemia 22: 231-239; advance online publication, November 1, 2007; doi:10.1038/sj.leu.2405016
Reviews
Genetics of therapy-related myelodysplasia and acute myeloid leukemia
J Pedersen-Bjergaard, M K Andersen, M T Andersen and D H Christiansen
Leukemia 22: 240-248; advance online publication, January 17, 2008; doi:10.1038/sj.leu.2405078
NK cell receptors and their ligands in leukemia
S Verheyden and C Demanet
Leukemia 22: 249-257; advance online publication, November 29, 2007; doi:10.1038/sj.leu.2405040
Original Articles
Therapy
Phase I/II study of gemtuzumab ozogamicin added to fludarabine, melphalan and allogeneic hematopoietic stem cell transplantation for high-risk CD33 positive myeloid leukemias and myelodysplastic syndrome
M de Lima, R E Champlin, P F Thall, X Wang, T G Martin III, J D Cook, G McCormick, M Qazilbash, P Kebriaei, D Couriel, E J Shpall, I Khouri, P Anderlini, C Hosing, K W Chan, B S Andersson, P A Patah, Z Caldera, E Jabbour and S Giralt
Leukemia 22: 258-264; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405014
Acute Leukemias
DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Oncology Group
D Bhatla, R B Gerbing, T A Alonzo, P A Mehta, K Deal, J Elliott, S Meshinchi, H Geiger, J P Perentesis, B J Lange and S M Davies
Leukemia 22: 265-272; advance online publication, November 22, 2007; doi:10.1038/sj.leu.2405000
Phosphorylation of PML is essential for activation of C/EBP
and PU.1 to accelerate granulocytic differentiation
Y Tagata, H Yoshida, L A Nguyen, H Kato, H Ichikawa, F Tashiro and I Kitabayashi
Leukemia 22: 273-280; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405024
Outcomes after HLA-matched sibling transplantation or chemotherapy in children with acute lymphoblastic leukemia in a second remission after an isolated central nervous system relapse: a collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research
M Eapen, M-J Zhang, M Devidas, E Raetz, J C Barredo, A K Ritchey, K Godder, S Grupp, V A Lewis, K Malloy, W L Carroll, S M Davies and B M Camitta
Leukemia 22: 281-286; advance online publication, November 22, 2007; doi:10.1038/sj.leu.2405037
Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels
K J Hatfield, R Hovland, A M Øyan, K H Kalland, A Ryningen, B T Gjertsen and Ø Bruserud
Leukemia 22: 287-293; advance online publication, October 18, 2007; doi:10.1038/sj.leu.2404985
Efficient detection of leukemia-related fusion transcripts by multiplex PCR applied on a microelectronic platform
B Corradi, G Fazio, C Palmi, V Rossi, A Biondi and G Cazzaniga
Leukemia 22: 294-302; advance online publication, October 18, 2007; doi:10.1038/sj.leu.2404987
Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples
L-Y Shih, D-C Liang, C-F Huang, Y-T Chang, C-L Lai, T-H Lin, C-P Yang, I-J Hung, H-C Liu, T-H Jaing, L-Y Wang and T-C Yeh
Leukemia 22: 303-307; advance online publication, October 25, 2007; doi:10.1038/sj.leu.2404995
High incidence of avascular necrosis in adolescents with acute lymphoblastic leukaemia: a UKALL XII analysis
B Patel, S M Richards, J M Rowe, A H Goldstone and A K Fielding
Leukemia 22: 308-312; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405032
Myelodysplasias
Marrow fibrosis predicts early fatal marrow failure in patients with myelodysplastic syndromes
G Buesche, H Teoman, W Wilczak, A Ganser, H Hecker, L Wilkens, G Göhring, B Schlegelberger, O Bock, A Georgii and H Kreipe
Leukemia 22: 313-322; advance online publication, November 22, 2007; doi:10.1038/sj.leu.2405030
Chronic Lymphocytic Leukemia
Efficient gene transfer in CLL by mRNA electroporation
F Van Bockstaele, V Pede, E Naessens, S Van Coppernolle, V Van Tendeloo, B Verhasselt and J Philippé
Leukemia 22: 323-329; advance online publication, November 1, 2007; doi:10.1038/sj.leu.2405007
Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis
S Marton, M R Garcia, C Robello, H Persson, F Trajtenberg, O Pritsch, C Rovira, H Naya, G Dighiero and A Cayota
Leukemia 22: 330-338; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405022
The BCL-2 promoter (-938C>A) polymorphism does not predict clinical outcome in chronic lymphocytic leukemia
M A Kaderi, M Norberg, F Murray, M Merup, C Sundström, G Roos, A Åleskog, K Karlsson, T Axelsson, G Tobin and R Rosenquist
Leukemia 22: 339-343; advance online publication, November 29, 2007; doi:10.1038/sj.leu.2405042
Immunology
Involvement of mature donor T cells in the NK cell reconstitution after haploidentical hematopoietic stem-cell transplantation
S Nguyen, M Kuentz, J-P Vernant, N Dhedin, D Bories, P Debré and V Vieillard
Leukemia 22: 344-352; advance online publication, November 22, 2007; doi:10.1038/sj.leu.2405041
Sensitivity and Resistance to Therapy
Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia
T Matsunaga, F Fukai, S Miura, Y Nakane, T Owaki, H Kodama, M Tanaka, T Nagaya, R Takimoto, T Takayama and Y Niitsu
Leukemia 22: 353-360; advance online publication, November 1, 2007; doi:10.1038/sj.leu.2405017
Apoptosis
Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis
W Qian, J Liu, Y Tong, S Yan, C Yang, M Yang and X Liu
Leukemia 22: 361-369; advance online publication, November 29, 2007; doi:10.1038/sj.leu.2405034
The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia
C Ploner, J Rainer, H Niederegger, M Eduardoff, A Villunger, S Geley and R Kofler
Leukemia 22: 370-377; advance online publication, November 29, 2007; doi:10.1038/sj.leu.2405039
Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity
Y Lu, Z-G Peng, T-T Yuan, Q-Q Yin, L Xia and G-Q Chen
Leukemia 22: 378-386; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405020
Lymphoma
Amplification at 7q22 targets cyclin-dependent kinase 6 in T-cell lymphoma
S Nagel, E Leich, H Quentmeier, C Meyer, M Kaufmann, H G Drexler, A Zettl, A Rosenwald and R A F MacLeod
Leukemia 22: 387-392; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405028
Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3
N Booken, A Gratchev, J Utikal, C Wei
, X Yu, M Qadoumi, M Schmuth, N Sepp, D Nashan, K Rass, T Tüting, C Assaf, E Dippel, R Stadler, C-D Klemke and S Goerdt
Leukemia 22: 393-399; advance online publication, November 22, 2007; doi:10.1038/sj.leu.2405044
Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell
M Montesinos-Rongen, A Brunn, S Bentink, K Basso, W K Lim, W Klapper, C Schaller, G Reifenberger, J Rubenstein, O D Wiestler, R Spang, R Dalla-Favera, R Siebert and M Deckert
Leukemia 22: 400-405; advance online publication, November 8, 2007; doi:10.1038/sj.leu.2405019
Myeloma
Atacicept (TACI-Ig) inhibits growth of TACI high primary myeloma cells in SCID-hu mice and in coculture with osteoclasts
S Yaccoby, A Pennisi, X Li, S R Dillon, F Zhan, B Barlogie and J D Shaughnessy Jr
Leukemia 22: 406-413; advance online publication, November 29, 2007; doi:10.1038/sj.leu.2405048
Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma
A Palumbo, S V Rajkumar, M A Dimopoulos, P G Richardson, J San Miguel, B Barlogie, J Harousseau, J A Zonder, M Cavo, M Zangari, M Attal, A Belch, S Knop, D Joshua, O Sezer, H Ludwig, D Vesole, J Bladé, R Kyle, J Westin, D Weber, S Bringhen, R Niesvizky, A Waage, M von Lilienfeld-Toal, S Lonial, G J Morgan, R Z Orlowski, K Shimizu, K C Anderson, M Boccadoro, B G Durie, P Sonneveld and M A Hussein on behalf of the International Myeloma Working Group
Leukemia 22: 414-423; advance online publication, December 20, 2007; doi:10.1038/sj.leu.2405062
Letters to the Editor
Nucleophosmin leukaemic mutants contain C-terminus peptides that bind HLA class I molecules
A Liso, D Colau, R Benmaamar, A De Groot, W Martin, R Benedetti, G Specchia, M P Martelli, P Coulie and B Falini
Leukemia 22: 424-426; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404887
CD34+/Ph+ cells are still detectable in chronic myeloid leukemia patients with sustained and prolonged complete cytogenetic remission during treatment with imatinib mesylate
M Bocchia, M Ippoliti, A Gozzetti, E Abruzzese, S Calabrese, M Amabile, M T Pirrotta, R Crupi, D Tozzuoli, M M Trawinska, M Defina, G Martinelli and F Lauria
Leukemia 22: 426-428; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404893
Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan
H Narimatsu, T Yokozawa, H Iida, M Tsuzuki, M Hayakawa, T Takeo, M Iino, T Ichihashi, C Kato, A Sawamoto, H Sao, M Yanada, N Emi, H kiyoi, T Yamaguchi, T Naoe, R Suzuki and I Sugiura
Leukemia 22: 428-432; advance online publication, August 16, 2007; doi:10.1038/sj.leu.2404905
Congenital transfusion-dependent anemia and thrombocytopenia with myelodysplasia due to a recurrent GATA1 G208R germline mutation
C P Kratz, C M Niemeyer, A Karow, M Volz-Fleckenstein, A Schmitt-Gräff and B Strahm
Leukemia 22: 432-434; advance online publication, August 23, 2007; doi:10.1038/sj.leu.2404904
A simple FISH assay for the detection of 3q26 rearrangements in myeloid malignancy
V De Melo, M Vetter, H Mazzullo, J D Howard, D R Betts, E P Nacheva, J F Apperley and A G Reid
Leukemia 22: 434-437; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404906
Proposed criteria for the diagnosis of post-polycythemia vera and post-essential thrombocythemia myelofibrosis: a consensus statement from the international working group for myelofibrosis research and treatment
G Barosi, R A Mesa, J Thiele, F Cervantes, P J Campbell, S Verstovsek, B Dupriez, R L Levine, F Passamonti, J Gotlib, J T Reilly, A M Vannucchi, C A Hanson, L A Solberg, A Orazi and A Tefferi On behalf of the International Working Group for Myelofibrosis Research and Treatment (IWG-MRT)
Leukemia 22: 437-438; advance online publication, August 30, 2007; doi:10.1038/sj.leu.2404914
Lack of a relationship between the common 8q24 variant rs6983267 and risk of chronic lymphocytic leukemia
G S Sellick, P Broderick, S Fielding, D Catovsky and R S Houlston
Leukemia 22: 438-439; advance online publication, August 23, 2007; doi:10.1038/sj.leu.2404915
High incidence of acute promyelocytic leukemia in children in northwest Italy, 1980–2003: a report from the Childhood Cancer Registry of Piedmont
M M Maule, E Dama, M L Mosso, C Magnani, G Pastore and F Merletti
Leukemia 22: 439-441; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404916
Expression of MUM1/IRF4 mRNA as a prognostic marker in patients with multiple myeloma
D Heintel, N Zojer, M Schreder, K Strasser-Weippl, B Kainz, M Vesely, H Gisslinger, J Drach, A Gaiger, U Jäger and H Ludwig
Leukemia 22: 441-445; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404895
Evidence for the interaction of imatinib at the transport-substrate site(s) of the multidrug-resistance-linked ABC drug transporters ABCB1 (P-glycoprotein) and ABCG2
S Shukla, Z E Sauna and S V Ambudkar
Leukemia 22: 445-447; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404897
A novel silver (I) chelate: cytotoxicity and apoptotic mechanism of action on human hematopoietic malignancies
K I Batarseh
Leukemia 22: 448-450; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404898
The JAK2 V617F mutation may be present several years before the occurrence of overt myeloproliferative disorders
C Bellanné-Chantelot, P Jego, P Lionne-Huyghe, M Tulliez and A Najman on behalf of the French group on myeloproliferative disorders
Leukemia 22: 450-451; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404896
Classification of myeloproliferative disorders in the JAK2 era: is there a role for red cell mass?
B Cassinat, C Laguillier, C Gardin, V de Beco, S Burcheri, P Fenaux, C Chomienne and J-J Kiladjian The PV-Nord Group
Leukemia 22: 452-453; advance online publication, August 23, 2007; doi:10.1038/sj.leu.2404908
Detection of an MPLW515 mutation in a case with features of both essential thrombocythemia and refractory anemia with ringed sideroblasts and thrombocytosis
S Schnittger, U Bacher, C Haferlach, R Dengler, A Kröber, W Kern and T Haferlach
Leukemia 22: 453-455; advance online publication, August 16, 2007; doi:10.1038/sj.leu.2404909
The DC-derived protein DC-STAMP influences differentiation of myeloid cells
D Eleveld-Trancikova, R A J Janssen, I A M Hendriks, M W G Looman, V Moulin, B J H Jansen, J H Jansen, C G Figdor and G J Adema
Leukemia 22: 455-459; advance online publication, August 23, 2007; doi:10.1038/sj.leu.2404910
Translocation t(4;14) retains prognostic significance even in the setting of high-risk molecular signature
W J Chng, W M Kuehl, P L Bergsagel and R Fonseca
Leukemia 22: 459-461; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404934
Corrigenda
Translocation t(4;14) retains prognostic significance even in the setting of high-risk molecular signature FREE
W J Chng, W M Kuehl, P L Bergsagel and R Fonseca
Leukemia 22: 462; doi:10.1038/sj.leu.2405089
Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study FREE
M Hedenus, G Birgegård, P Näsman, L Ahlberg, T Karlsson, B Lauri, J Lundin, G Lärfars and A Österborg
Leukemia 22: 462; doi:10.1038/sj.leu.2405094