Leukemia

FIGURE 1

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Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

V Papa, P L Tazzari, F Chiarini, A Cappellini, F Ricci, A M Billi, C Evangelisti, E Ottaviani, G Martinelli, N Testoni, J A McCubrey and A M Martelli

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Figure 1.

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Perifosine cytotoxicity and apoptosis induction in AML cell lines. (a) MTT assays of THP-1 and MV 4–11 cells cultured with perifosine for 24 or 48 h. Results are the mean of three different experimentsplusminuss.d. Asterisk indicates statistically significant difference (P<0.005) with respect to untreated cells. (b) Representative histograms showing flow cytometric analysis of Annexin V-FITC/PI-stained THP-1 cells. CTRL, untreated cells. Cells were cultured with perifosine for 24 h. AML, acute myelogenous leukemia; G1, necrotic cells; G2, secondary necrotic cells; G3, healthy cells; G4, apoptotic cells; MTT, (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; PI, propidium iodide.

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