FIGURE 4
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Bortezomib is synergistic with rituximab and cyclophosphamide in inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo
M Wang, X H Han, L Zhang, J Yang, J F Qian, Y K Shi, L W Kwak, J Romaguera and Q Yi
BACK TO ARTICLEFigure 4.
Caspase activation and cleavage by BTZ, RTX, CTX, RC and BRC-treated MCL cells. (a) Activation and cleavage of caspases-8, -9 and -3 and PARP in Jeko-1 and Grant 519 cells for different culture times. Whole cell lysates were prepared and subjected to western blot analysis. (b) Caspase inhibition assay on Jeko-1 and Grant 519 cells. Shown is the inhibition of apoptosis by the pan-caspase inhibitor Z-VAD-fmk (ZVAD) in MCL cells treated with BTZ, CTX, RTX, or BRC. Representative results of three experiments performed are shown.