TABLE OF CONTENTS
Volume 22, Issue 1 (January 2008)
Spotlight Reviews |
Reviews |
Original Articles |
Letters to the Editor |
Corrigendum
Spotlight Editorial
Introduction to 'A special spotlight review series on BCR–ABL-negative myeloproliferative neoplasms' FREE
A Tefferi and S N Constantinescu
Leukemia 22: 1; doi:10.1038/sj.leu.2404984
Spotlight Reviews
Myeloproliferative Neoplasms
Introduction to 'Spotlight on myeloproliferative neoplasms' FREE
C N Muller-Berat Killmann MD, PhD Editor-in-Chief
Leukemia 22: 2; doi:10.1038/sj.leu.2405046
The history of myeloproliferative disorders: before and after Dameshek FREE
A Tefferi
Leukemia 22: 3-13; advance online publication, September 20, 2007; doi:10.1038/sj.leu.2404946
Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms FREE
A Tefferi and J W Vardiman
Leukemia 22: 14-22; advance online publication, September 20, 2007; doi:10.1038/sj.leu.2404955
JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials FREE
A Pardanani
Leukemia 22: 23-30; advance online publication, September 20, 2007; doi:10.1038/sj.leu.2404948
Reduced-Intensity Stem Cell Conditioning
Current status of reduced-intensity allogeneic stem cell transplantation using alternative donors FREE
Y-B Chen and T R Spitzer
Leukemia 22: 31-41; advance online publication, September 6, 2007; doi:10.1038/sj.leu.2404932
Reviews
Recent advances in adult T-cell leukemia therapy: focus on a new anti-transferrin receptor monoclonal antibody FREE
C Callens, I C Moura, Y Lepelletier, S Coulon, A Renand, M Dussiot, D Ghez, M Benhamou, R C Monteiro, A Bazarbachi and O Hermine
Leukemia 22: 42-48; advance online publication, September 27, 2007; doi:10.1038/sj.leu.2404958
Lymphoma microenvironment: culprit or innocent? FREE
B Herreros, A Sanchez-Aguilera and M A Piris
Leukemia 22: 49-58; advance online publication, October 4, 2007; doi:10.1038/sj.leu.2404970
Original Articles
Acute Leukemias
Time-course-dependent microvascular alterations in a model of myeloid leukemia in vivo FREE
C Schaefer, M Krause, I Fuhrhop, M Schroeder, P Algenstaedt, W Fiedler, W Rüther and N Hansen-Algenstaedt
Leukemia 22: 59-65; advance online publication, September 27, 2007; doi:10.1038/sj.leu.2404947
MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment FREE
M C Stubbs, Y M Kim, A V Krivtsov, R D Wright, Z Feng, J Agarwal, A L Kung and S A Armstrong
Leukemia 22: 66-77; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404951
Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation FREE
S Agrawal, S Koschmieder, N Bäumer, N G P Reddy, W E Berdel, C Müller-Tidow and H Serve
Leukemia 22: 78-86; advance online publication, October 18, 2007; doi:10.1038/sj.leu.2404988
Chronic Myeloproliferative Disorders
Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F FREE
K Shide, H K Shimoda, T Kumano, K Karube, T Kameda, K Takenaka, S Oku, H Abe, K S Katayose, Y Kubuki, K Kusumoto, S Hasuike, Y Tahara, K Nagata, T Matsuda, K Ohshima, M Harada and K Shimoda
Leukemia 22: 87-95; advance online publication, November 22, 2007; doi:10.1038/sj.leu.2405043
Harmonization of BCR-ABL mRNA quantification using a uniform multifunctional control plasmid in 37 international laboratories FREE
M C Müller, P Erben, G Saglio, E Gottardi, C G Nyvold, T Schenk, T Ernst, S Lauber, J Kruth, R Hehlmann and A Hochhaus on behalf of the European LeukemiaNet
Leukemia 22: 96-102; advance online publication, October 18, 2007; doi:10.1038/sj.leu.2404983
Stem Cells
Organ-injury-induced reactivation of hemangioblastic precursor cells FREE
B Dekel, S Metsuyanim, A M Garcia, C Quintero, M J Sanchez and S Izraeli
Leukemia 22: 103-113; advance online publication, September 27, 2007; doi:10.1038/sj.leu.2404941
Cytogenetics and Molecular Genetics
Disruption of ETV6 in intron 2 results in upregulatory and insertional events in childhood acute lymphoblastic leukaemia FREE
G R Jalali, Q An, Z J Konn, H Worley, S L Wright, C J Harrison, J C Strefford and M Martineau
Leukemia 22: 114-123; advance online publication, November 1, 2007; doi:10.1038/sj.leu.2404994
Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences FREE
M van Grotel, J P P Meijerink, E R van Wering, A W Langerak, H B Beverloo, J G C A M Buijs-Gladdines, N B Burger, M Passier, E M van Lieshout, W A Kamps, A J P Veerman, M M van Noesel and R Pieters
Leukemia 22: 124-131; advance online publication, October 11, 2007; doi:10.1038/sj.leu.2404957
Hyperdiploid karyotypes in acute myeloid leukemia define a novel entity: a study of 38 patients from the Groupe Francophone de Cytogenetique Hematologique (GFCH) FREE
I Luquet, J L Laï, C Barin, L Baranger, C Bilhou-Nabera, E Lippert, C Gervais, P Talmant, P Cornillet-Lefebvre, C Perot, N Nadal, M J Mozziconacci, M Lafage-Pochitaloff, V Eclache, F Mugneret, C Lefebvre, C Herens, F Speleman, H Poirel, I Tigaud, C Cabrol, P Rousselot, S Daliphard, M Imbert, R Garand, F Geneviève, R Berger and C Terre
Leukemia 22: 132-137; advance online publication, October 11, 2007; doi:10.1038/sj.leu.2404974
Transcriptional Control and Signal Transduction
Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway FREE
J Zhou, M Pan, Z Xie, S-L Loh, C Bi, Y-C Tai, M Lilly, Y-P Lim, J-H Han, K B Glaser, D H Albert, S K Davidsen and C-S Chen
Leukemia 22: 138-146; advance online publication, October 18, 2007; doi:10.1038/sj.leu.2404960
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells FREE
V Papa, P L Tazzari, F Chiarini, A Cappellini, F Ricci, A M Billi, C Evangelisti, E Ottaviani, G Martinelli, N Testoni, J A McCubrey and A M Martelli
Leukemia 22: 147-160; advance online publication, October 11, 2007; doi:10.1038/sj.leu.2404980
Differentiation
Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-
2 and MAP kinases ERK1 and ERK2 FREE
C Bourgin-Hierle, S Gobert-Gosse, J Thérier, M-F Grasset and G Mouchiroud
Leukemia 22: 161-169; advance online publication, November 1, 2007; doi:10.1038/sj.leu.2404986
Animal Models
A novel nude mice model of human extranodal nasal type NK/T-cell lymphoma FREE
S Zhao, Q L Tang, M X He, F Yang, H Wang, W Y Zhang, W Jiang, X L Wang, X M Mo, G D Li and W P Liu
Leukemia 22: 170-178; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404945
Lymphoma
Bortezomib is synergistic with rituximab and cyclophosphamide in inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo FREE
M Wang, X H Han, L Zhang, J Yang, J F Qian, Y K Shi, L W Kwak, J Romaguera and Q Yi
Leukemia 22: 179-185; advance online publication, September 27, 2007; doi:10.1038/sj.leu.2404959
Letters to the Editor
Absence of microsatellite instability in human chronic lymphocytic leukaemia B cells FREE
F Praz, F Le Page, L Vallat, F Davi, F Nguyen-Khac, K Maloum, J Delic and H Merle-Béral
Leukemia 22: 186-189; advance online publication, August 2, 2007; doi:10.1038/sj.leu.2404889
Childcare in the first 2 years of life reduces the risk of childhood acute lymphoblastic leukemia FREE
M Kamper-Jørgensen, A Woodward, J Wohlfahrt, C S Benn, J Simonsen, H Hjalgrim and K Schmiegelow
Leukemia 22: 189-193; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404884
Quantitative assessment of the JAK2 V617F allele burden: equivalent levels in peripheral blood and bone marrow FREE
T S Larsen, N Pallisgaard, M B Møller and H C Hasselbalch
Leukemia 22: 194-195; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404861
Absence of nucleophosmin leukaemic mutants in B and T cells from AML with NPM1 mutations: implications for the cell of origin of NPMc+ AML FREE
M P Martelli, N Manes, V Pettirossi, A Liso, R Pacini, R Mannucci, T Zei, N Bolli, F di Raimondo, G Specchia, I Nicoletti, M F Martelli and B Falini
Leukemia 22: 195-198; advance online publication, July 19, 2007; doi:10.1038/sj.leu.2404857
PI-PLC
-1 and activated Akt levels are linked to azacitidine responsiveness in high-risk myelodysplastic syndromes FREE
M Y Follo, C Finelli, C Bosi, G Martinelli, S Mongiorgi, M Baccarani, L Manzoli, W L Blalock, A M Martelli and L Cocco
Leukemia 22: 198-200; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404855
The presence of a single PML-RARA isoform lacking exon 5 in FISH-negative APL samples FREE
O Ashur-Fabian, L Trakhtenbrot, D Dominissini, M Koren-Michowitz, A Nagler, G Rechavi and N Amariglio
Leukemia 22: 200-203; advance online publication, October 25, 2007; doi:10.1038/sj.leu.2404991
Transplantation of human peripheral blood CD34-positive cells in combination with ex vivo generated megakaryocytes results in fast platelet formation in NOD/SCID mice FREE
M R Tijssen, P B van Hennik, F di Summa, J J Zwaginga, C E van der Schoot and C Voermans
Leukemia 22: 203-208; advance online publication, October 18, 2007; doi:10.1038/sj.leu.2404979
Genomic analysis of different clonal evolution in a twin pair with t(12;21) positive acute lymphoblastic leukemia sharing the same prenatal clone FREE
S Bungaro, J Irving, R Tussiwand, R Mura, L Minto, C Molteni, M Citterio, A Hall, A Biondi and G Cazzaniga
Leukemia 22: 208-211; advance online publication, October 11, 2007; doi:10.1038/sj.leu.2404973
Determination of IGHV gene mutational status in chronic lymphocytic leukemia: bioinformatics advances meet clinical needs FREE
F Davi, R Rosenquist, P Ghia, C Belessi and K Stamatopoulos
Leukemia 22: 212-214; advance online publication, October 4, 2007; doi:10.1038/sj.leu.2404969
Reply to 'Rituximab in CD20 positive multiple myeloma' by P Moreau et al. FREE
P T Greipp, P Kapoor, W G Morice, T E Witzig and P R Greipp
Leukemia 22: 214-215; advance online publication, October 11, 2007; doi:10.1038/sj.leu.2404972
Analysis of the exon 12 and 14 mutations of the JAK2 gene in Philadelphia chromosome-positive leukemia FREE
M Inami, H Yamaguchi, S Hasegawa, Y Mitamura, F Kosaka, A Kobayashi, S Kimura, K Dan and K Inokuchi
Leukemia 22: 216; advance online publication, September 13, 2007; doi:10.1038/sj.leu.2404953
A PDGFRB-positive acute myeloid malignancy with a new t(5;12)(q33;p13.3) involving the ERC1 gene FREE
P Gorello, R La Starza, L Brandimarte, S M Trisolini, V Pierini, B Crescenzi, M Z Limongi, M Nanni, E Belloni, C Tapinassi, E Gerbino, M F Martelli, R Foà, G Meloni, P G Pelicci and C Mecucci
Leukemia 22: 216-218; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404894
Different genomic imbalances in low- and high-grade HCV-related lymphomas FREE
C Matteucci, M Bracci, G Barba, M Carbonari, M Casato, M Visentini, A Pulsoni, E Varasano, G Roti, R La Starza, B Crescenzi, M F Martelli, M Fiorilli and C Mecucci
Leukemia 22: 219-222; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404872
The high frequency of T regulatory cells in patients with B-cell chronic lymphocytic leukemia is diminished through treatment with thalidomide FREE
K Giannopoulos, M Schmitt, P W
asiuk, J Chen, A Bojarska-Junak, M Kowal, J Roliñski and A Dmoszyñska
Leukemia 22: 222-224; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404869
Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10 FREE
D Benedetti, R Bomben, M Dal-Bo, D Marconi, A Zucchetto, M Degan, F Forconi, G Del-Poeta, G Gaidano and V Gattei
Leukemia 22: 224-226; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404867
Differential expression of Sonic hedgehog and Gli1 in hematological malignancies FREE
L-Y Bai, C-F Chiu, C-W Lin, N-Y Hsu, C-L Lin, W-J Lo and M-C Kao
Leukemia 22: 226-228; advance online publication, October 11, 2007; doi:10.1038/sj.leu.2404978