TABLE OF CONTENTS
Volume 21, Issue 9 (September 2007)
Editorial
Nucleophosmin mutations in acute myeloid leukemia in children
H J Lawrence
Leukemia 21: 1849-1850; doi:10.1038/sj.leu.2404809
Spotlight Review
Mini–Midi–Maxi? How to harness the graft-versus-myeloma effect and target molecular remission after allogeneic stem cell transplantation
N Kröger
Leukemia 21: 1851-1858; advance online publication, June 14, 2007; doi:10.1038/sj.leu.2404775
Reviews
Identification of T-cell epitopes for cancer immunotherapy
J H Kessler and C J M Melief
Leukemia 21: 1859-1874; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404787
The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma
E Terpos, M-A Dimopoulos and O Sezer
Leukemia 21: 1875-1884; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404843
The role of prognostic factors in assessing 'high-risk' subgroups of patients with chronic lymphocytic leukemia
N E Kay, S M O'Brien, A R Pettitt and S Stilgenbauer
Leukemia 21: 1885-1891; advance online publication, June 14, 2007; doi:10.1038/sj.leu.2404802
Original Articles
Molecular Targets For Therapy
The histone deacetylase inhibitor ITF2357 has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells
J Golay, L Cuppini, F Leoni, C Micò, V Barbui, M Domenghini, L Lombardi, A Neri, A M Barbui, A Salvi, P Pozzi, G Porro, P Pagani, G Fossati, P Mascagni, M Introna and A Rambaldi
Leukemia 21: 1892-1900; advance online publication, July 19, 2007; doi:10.1038/sj.leu.2404860
Acute Leukemias
Circulating angiopoietin-2 is a strong prognostic factor in acute myeloid leukemia
C Schliemann, R Bieker, N Thoennissen, J Gerss, R Liersch, T Kessler, T Büchner, W E Berdel and R M Mesters
Leukemia 21: 1901-1906; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404820
Outcome of treatment after first relapse in adults with acute lymphoblastic leukemia initially treated by the LALA-94 trial
E Tavernier, J-M Boiron, F Huguet, K Bradstock, N Vey, T Kovacsovics, A Delannoy, N Fegueux, P Fenaux, A Stamatoullas, O Tournilhac, A Buzyn, O Reman, C Charrin, C Boucheix, J Gabert, V Lhéritier, J-P Vernant, H Dombret and X Thomas for the GET-LALA Group, the Swiss Group for Clinical Cancer Research SAKK and the Australasian Leukaemia and Lymphoma Group
Leukemia 21: 1907-1914; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404824
Induction of acute lymphocytic leukemia differentiation by maintenance therapy
T L Lin, M S Vala, J P Barber, J E Karp, B D Smith, W Matsui and R J Jones
Leukemia 21: 1915-1920; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404823
Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway
K T Doepfner, O Spertini and A Arcaro
Leukemia 21: 1921-1930; advance online publication, June 21, 2007; doi:10.1038/sj.leu.2404813
Myelodisplasias
Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice
S Lehmann, J O'Kelly, S Raynaud, S E Funk, E H Sage and H P Koeffler
Leukemia 21: 1931-1936; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404852
CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine
K Raj, A John, A Ho, C Chronis, S Khan, J Samuel, S Pomplun, N S B Thomas and G J Mufti
Leukemia 21: 1937-1944; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404796
A retrospective comparison of autologous and unrelated donor hematopoietic cell transplantation in myelodysplastic syndrome and secondary acute myeloid leukemia: a report on behalf of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
H K Al-Ali, R Brand, A van Biezen, J Finke, M Boogaerts, A A Fauser, M Egeler, J-Y Cahn, R Arnold, H Biersack, D Niederwieser and T de Witte
Leukemia 21: 1945-1951; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404774
Chronic Myeloproliferative Disorder
Prospective identification of high-risk polycythemia vera patients based on JAK2 V617F allele burden
A M Vannucchi, E Antonioli, P Guglielmelli, G Longo, A Pancrazzi, V Ponziani, C Bogani, P R Ferrini, A Rambaldi, V Guerini, A Bosi and T Barbui for the MPD Research Consortium
Leukemia 21: 1952-1959; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404854
Prevalence and clinicopathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera
A Pardanani, T L Lasho, C Finke, C A Hanson and A Tefferi
Leukemia 21: 1960-1963; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404810
A phase II trial of tipifarnib in myelofibrosis: primary, post-polycythemia vera and post-essential thrombocythemia
R A Mesa, J K Camoriano, S M Geyer, W Wu, S H Kaufmann, C E Rivera, C Erlichman, J Wright, A Pardanani, T Lasho, C Finke, C Y Li and A Tefferi
Leukemia 21: 1964-1970; advance online publication, June 21, 2007; doi:10.1038/sj.leu.2404816
Expression of the p210BCR-ABL oncoprotein drives centrosomal hypertrophy and clonal evolution in human U937 cells
M Giehl, A Fabarius, O Frank, P Erben, C Zheng, M Hafner, A Hochhaus, R Hehlmann and W Seifarth
Leukemia 21: 1971-1976; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404834
Chronic Lymphocytic Leukemia
Efficient nucleofection of primary human B cells and B-CLL cells induces apoptosis, which depends on the microenvironment and on the structure of transfected nucleic acids
M Seiffert, S Stilgenbauer, H Döhner and P Lichter
Leukemia 21: 1977-1983; advance online publication, July 19, 2007; doi:10.1038/sj.leu.2404863
Molecular heterogeneity in chronic lymphocytic leukemia is dependent on BCR signaling: clinical correlation
A Rodríguez, R Villuendas, L Yáñez, M E Gómez, R Díaz, M Pollán, N Hernández, P de la Cueva, M C Marín, A Swat, E Ruiz, M A Cuadrado, E Conde, L Lombardía, F Cifuentes, M Gonzalez, J A García-Marco and M A Piris for Spanish National Cancer Centre (CNIO)
Leukemia 21: 1984-1991; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404831
Stem Cells
Mesenchymal stem cells of cord blood origin are effective at preventing but not treating graft-versus-host disease
V Tisato, K Naresh, J Girdlestone, C Navarrete and F Dazzi
Leukemia 21: 1992-1999; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404847
Genomics, Gene Therapy And Proteomics
Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias
C G Mullighan, A Kennedy, X Zhou, I Radtke, L A Phillips, S A Shurtleff and J R Downing
Leukemia 21: 2000-2009; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404808
Transcriptional Control And Signal Transduction
The multi-functional cellular adhesion molecule CD44 is regulated by the 8;21 chromosomal translocation
L F Peterson, Y Wang, M-C Lo, M Yan, E Kanbe and D-E Zhang
Leukemia 21: 2010-2019; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404849
Myeloma
Heterogeneity of t(4;14) in multiple myeloma. Long-term follow-up of 100 cases treated with tandem transplantation in IFM99 trials
P Moreau, M Attal, F Garban, C Hulin, T Facon, G Marit, M Michallet, C Doyen, S Leyvraz, M Mohty, M Wetterwald, C Mathiot, D Caillot, C Berthou, L Benboubker, L Garderet, C Chaleteix, C Traullé, J G Fuzibet, J Jaubert, T Lamy, P Casassus, M Dib, B Kolb, V Dorvaux, B Grosbois, I Yakoub-Agha, J L Harousseau and H Avet-Loiseau on behalf of the SAKK and IFM group
Leukemia 21: 2020-2024; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404832
Bortezomib inhibits human osteoclastogenesis
I von Metzler, H Krebbel, M Hecht, R A Manz, C Fleissner, M Mieth, M Kaiser, C Jakob, J Sterz, L Kleeberg, U Heider and O Sezer
Leukemia 21: 2025-2034; advance online publication, June 21, 2007; doi:10.1038/sj.leu.2404806
Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma
S Kumar, A Dispenzieri, M Q Lacy, S R Hayman, F K Buadi, D A Gastineau, M R Litzow, R Fonseca, V Roy, S V Rajkumar and M A Gertz
Leukemia 21: 2035-2042; advance online publication, June 21, 2007; doi:10.1038/sj.leu.2404801
Letters to the Editor
Novel multi-parameter flow cytometry sensitively detects phenotypically distinct plasma cell subsets in plasma cell proliferative disorders
W G Morice, C A Hanson, S Kumar, L A Frederick, C E Lesnick and P R Greipp
Leukemia 21: 2043-2046; advance online publication, April 26, 2007; doi:10.1038/sj.leu.2404712
A single-tube six-colour flow cytometry screening assay for the detection of minimal residual disease in myeloma
R M de Tute, A S Jack, J A Child, G J Morgan, R G Owen and A C Rawstron
Leukemia 21: 2046-2049; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404815
Splenectomy status of the patient may have impact on response to donor lymphocyte infusions
D Uckan-Çetinkaya, S Unal, M Çetin, Ü Sarikabadayi, D Akta
and Y Koç
Leukemia 21: 2049-2050; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404803
Reply to 'Splenectomy status of the patient may have impact on response to donor lymphocyte infusions' by Duygu Uckan-Çetinkaya et al.
F Dazzi and C Fozza
Leukemia 21: 2050-2051; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404804
Myeloproliferative disorders with coexisting BCR-ABL translocation and JAK2V617F mutation
R S Go
Leukemia 21: 2051; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404825
Reply to 'Myeloproliferative disorders with coexisting BCR-ABL translocation and JAK2V617F mutation' by Dr Ronald S Go
M Inami, K Inokuchi, H Yamaguchi and K Dan
Leukemia 21: 2052; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404826
Aberrant cytoplasmic expression of C-terminal-truncated NPM leukaemic mutant is dictated by tryptophans loss and a new NES motif
B Falini, E Albiero, N Bolli, M F De Marco, D Madeo, M Martelli, I Nicoletti and F Rodeghiero
Leukemia 21: 2052-2054; advance online publication, July 19, 2007; doi:10.1038/sj.leu.2404839
Reply to 'Aberrant cytoplasmic expression of C-terminal truncated NPM leukaemic mutant is dictated by tryptophans loss and a new NES motif' by Falini et al.
A S Pitiot, I Santamaría, O García-Suárez, I Centeno, A Astudillo, C Rayón and M Balbín
Leukemia 21: 2054; advance online publication, July 19, 2007; doi:10.1038/sj.leu.2404840
'Reply to Pitiot et al.'
B Falini, E Albiero, N Bolli, M F De Marco, D Madeo, M Martelli, I Nicoletti and F Rodeghiero
Leukemia 21: 2055-2056; advance online publication, July 19, 2007; doi:10.1038/sj.leu.2404841
Molecular detection of GNNK- and GNNK+ c-kit isoforms: a new tool for risk stratification in adult acute myeloid leukaemia
F Guerrini, S Galimberti, E Ciabatti, S Brizzi, R Testi, A Pollastrini, B Falini and M Petrini
Leukemia 21: 2056-2058; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404726
Single nucleotide polymorphism arrays complement metaphase cytogenetics in detection of new chromosomal lesions in MDS
L P Gondek, R Tiu, A S Haddad, C L O'Keefe, M A Sekeres, K S Theil and J P Maciejewski
Leukemia 21: 2058-2061; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404745
Elevated mRNA transcripts of non-homologous end-joining genes in pediatric acute lymphoblastic leukemia
S-S Chiou, J-L Huang, Y-S Tsai, T-F Chen, K-W Lee, S-H H Juo, Y-J Jong, C-H Hung, T-T Chang and C-S Lin
Leukemia 21: 2061-2064; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404742
Conventional cytogenetics of nodular lymphocyte-predominant Hodgkin's lymphoma
A Stamatoullas, J-M Picquenot, C Dumesnil, P Ruminy, D Penther, P Bertrand, M-N Courel, C Maisonneuve, A François, P Gaulard, H Tilly and C Bastard
Leukemia 21: 2064-2067; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404736
HS1 complexes with cytoskeleton adapters in normal and malignant chronic lymphocytic leukemia B cells
M Muzio, C Scielzo, M Frenquelli, A Bachi, M De Palma, M Alessio, P Ghia and F Caligaris-Cappio
Leukemia 21: 2067-2070; advance online publication, May 17, 2007; doi:10.1038/sj.leu.2404744
Busulphan is safe and efficient treatment in elderly patients with essential thrombocythemia
L Shvidel, E Sigler, M Haran, A Klepfish, A Duek, A Berrebi and M Shtalrid
Leukemia 21: 2071-2072; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404743
A reappraisal by quantitative flow cytometry analysis of PTEN expression in acute leukemia
J Yang, J Liu, J Zheng, W Du, Y He, W Liu and S Huang
Leukemia 21: 2072-2074; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404740
Bone marrow JAK2V617F allele burden and clinical correlates in polycythemia vera
A Tefferi, J J Strand, T L Lasho, R A Knudson, C M Finke, N Gangat, A Pardanani, C A Hanson and R P Ketterling
Leukemia 21: 2074-2075; advance online publication, May 3, 2007; doi:10.1038/sj.leu.2404724
History of infections and vaccinations and risk of lymphoid neoplasms: does influenza immunization reduce the risk?
A Monnereau, L Orsi, X Troussard, C Berthou, P Fenaux, G Marit, P Soubeyran, F Huguet, N Milpied, M Leporrier, D Hemon and J Clavel
Leukemia 21: 2075-2079; advance online publication, May 17, 2007; doi:10.1038/sj.leu.2404738
Interstitial del(14)(q) involving IGH: a novel recurrent aberration in B-NHL
H Pospisilova, M Baens, L Michaux, M Stul, P Van Hummelen, P Van Loo, J Vermeesch, M Jarosova, Z Zemanova, K Michalova, I Van den Berghe, H D Alexander, A Hagemeijer, P Vandenberghe, J Cools, C De Wolf-Peeters, P Marynen and I Wlodarska
Leukemia 21: 2079-2083; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404739
