Imaging and angiogenesis in hematological malignancies

V Longo, A Vacca and D Ribatti

Leukemia 21: 1605; doi:10.1038/sj.leu.2404790

Abstract | Full Text | PDF

The history of angiogenesis inhibitors

D Ribatti

Leukemia 21: 1606-1609; doi:10.1038/sj.leu.2404756

Abstract | Full Text | PDF

Deguelin inhibits expression of IB protein and induces apoptosis of B-CLL cells in vitro

B Geeraerts, B Vanhoecke, W Vanden Berghe, J Philippé, F Offner and D Deforce

Leukemia 21: 1610-1618; advance online publication, June 14, 2007; doi:10.1038/sj.leu.2404788

Abstract | Full Text | PDF | Supplementary information

The hunt for cancer-initiating cells: a history stemming from leukemia

M P Buzzeo, E W Scott and C R Cogle

Leukemia 21: 1619-1627; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404768

Abstract | Full Text | PDF

Immune reconstitution after allogeneic stem cell transplantation with reduced-intensity conditioning regimens

M Jiménez, G Ercilla and C Martínez

Leukemia 21: 1628-1637; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404681

Abstract | Full Text | PDF

The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia

J-H Mikesch, B Steffen, W E Berdel, H Serve and C Müller-Tidow

Leukemia 21: 1638-1647; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404732

Abstract | Full Text | PDF

Clonality of the stem cell compartment during evolution of myelodysplastic syndromes and other bone marrow failure syndromes

R Tiu, L Gondek, C O'Keefe and J P Maciejewski

Leukemia 21: 1648-1657; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404757

Abstract | Full Text | PDF

Molecular Targets for Therapy

TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

A Pardanani, J Hood, T Lasho, R L Levine, M B Martin, G Noronha, C Finke, C C Mak, R Mesa, H Zhu, R Soll, D G Gilliland and A Tefferi

Leukemia 21: 1658-1668; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404750

Abstract | Full Text | PDF | Supplementary information

Acute Leukemias

Impairment of Na⁺,K⁺-ATPase in CD95(APO-1)-induced human T-cell leukemia cell apoptosis mediated by glutathione depletion and generation of hydrogen peroxide

W Yin, W Cheng, W Shen, L Shu, J Zhao, J Zhang and Z-C Hua

Leukemia 21: 1669-1678; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404791

Abstract | Full Text | PDF | Supplementary information

MN1 overexpression is an important step in the development of inv(16) AML

C Carella, J Bonten, S Sirma, T A Kranenburg, S Terranova, R Klein-Geltink, S Shurtleff, J R Downing, E C Zwarthoff, P P Liu and G C Grosveld

Leukemia 21: 1679-1690; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404778

Abstract | Full Text | PDF | Supplementary information

Proinflammatory response of human leukemic cells to dsRNA transfection linked to activation of dendritic cells

E L J M Smits, P Ponsaerts, A L R Van de Velde, A Van Driessche, N Cools, M Lenjou, G Nijs, D R Van Bockstaele, Z N Berneman and V F I Van Tendeloo

Leukemia 21: 1691-1699; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404763

Abstract | Full Text | PDF | Supplementary information

Aberrant marker expression patterns on the CD34+CD38- stem cell compartment in acute myeloid leukemia allows to distinguish the malignant from the normal stem cell compartment both at diagnosis and in remission

A van Rhenen, B Moshaver, A Kelder, N Feller, A W M Nieuwint, S Zweegman, G J Ossenkoppele and G J Schuurhuis

Leukemia 21: 1700-1707; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404754

Abstract | Full Text | PDF

Chronic Myeloproliferative Disorders

The -kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34⁺ CML progenitor cells

J Burthem, K Rees-Unwin, R Mottram, J Adams, G S Lucas, E Spooncer and A D Whetton

Leukemia 21: 1708-1714; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404762

Abstract | Full Text | PDF

Chronic Lymphocytic Leukemia

Chromosomal translocations independently predict treatment failure, treatment-free survival and overall survival in B-cell chronic lymphocytic leukemia patients treated with cladribine

E Van Den Neste, V Robin, J Francart, A Hagemeijer, M Stul, P Vandenberghe, A Delannoy, A Sonet, V Deneys, S Costantini, A Ferrant, A Robert and L Michaux

Leukemia 21: 1715-1722; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404764

Abstract | Full Text | PDF | Supplementary information

Stem Cells

Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells

A M Glodek, Y Le, D M Dykxhoorn, S-Y Park, G Mostoslavsky, R Mulligan, J Lieberman, H E Beggs, M Honczarenko and L E Silberstein

Leukemia 21: 1723-1732; advance online publication, June 14, 2007; doi:10.1038/sj.leu.2404769

Abstract | Full Text | PDF

Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells

K Le Blanc, H Samuelsson, B Gustafsson, M Remberger, B Sundberg, J Arvidson, P Ljungman, H Lönnies, S Nava and O Ringdén

Leukemia 21: 1733-1738; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404777

Abstract | Full Text | PDF

Cytogenetics and Molecular Genetics

Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma

K Busch, T Keller, U Fuchs, R-F Yeh, J Harbott, I Klose, J Wiemels, A Novosel, A Reiter and A Borkhardt

Leukemia 21: 1739-1751; advance online publication, May 31, 2007; doi:10.1038/sj.leu.2404753

Abstract | Full Text | PDF | Supplementary information

Transcriptional Control and Deregulation

Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-B in adult T-cell leukemia/lymphoma

M V P Nadella, W P Dirksen, K S Nadella, S Shu, A S Cheng, J A Morgenstern, V Richard, S A Fernandez, T H Huang, D Guttridge and T J Rosol

Leukemia 21: 1752-1762; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404798

Abstract | Full Text | PDF

Apoptosis

BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts

T M Kohl, C Hellinger, F Ahmed, C Buske, W Hiddemann, S K Bohlander and K Spiekermann

Leukemia 21: 1763-1772; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404776

Abstract | Full Text | PDF | Supplementary information

Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa

S Inoue, J Riley, T W Gant, M J S Dyer and G M Cohen

Leukemia 21: 1773-1782; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404760

Abstract | Full Text | PDF | Supplementary information

Animal Models

The Wilms' tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis

N Hosen, T Shirakata, S Nishida, M Yanagihara, A Tsuboi, M Kawakami, Y Oji, Y Oka, M Okabe, B Tan, H Sugiyama and I L Weissman

Leukemia 21: 1783-1791; advance online publication, May 24, 2007; doi:10.1038/sj.leu.2404752

Abstract | Full Text | PDF

Lymphoma

PS-341 or a combination of arsenic trioxide and interferon- inhibit growth and induce caspase-dependent apoptosis in KSHV/HHV-8-infected primary effusion lymphoma cells

R Abou-Merhi, R Khoriaty, D Arnoult, H El Hajj, H Dbouk, S Munier, M E El-Sabban, O Hermine, A Gessain, H de Thé, R Mahieux and A Bazarbachi

Leukemia 21: 1792-1801; advance online publication, June 14, 2007; doi:10.1038/sj.leu.2404797

Abstract | Full Text | PDF

Prolonged survival in poor-risk diffuse large B-cell lymphoma following front-line treatment with rituximab-supplemented, early-intensified chemotherapy with multiple autologous hematopoietic stem cell support: a multicenter study by GITIL (Gruppo Italiano Terapie Innovative nei Linfomi)

C Tarella, M Zanni, M Di Nicola, C Patti, R Calvi, A Pescarollo, V Zoli, A Fornari, D Novero, A Cabras, M Stella, A Comino, D Remotti, M Ponzoni, D Caracciolo, M Ladetto, M Magni, L Devizzi, R Rosato, M Boccadoro, M Bregni, P Corradini, A Gallamini, I Majolino, S Mirto and A M Gianni on behalf of the Gruppo Italiano Terapie Innovative nei Linfomi (GITIL)

Leukemia 21: 1802-1811; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404781

Abstract | Full Text | PDF

MALT lymphoma in patients with autoimmune diseases: a comparative analysis of characteristics and clinical course

S Wöhrer, M Troch, B Streubel, J Zwerina, C Skrabs, M Formanek, W Hauff, M Hoffmann, L Müllauer, A Chott and M Raderer

Leukemia 21: 1812-1818; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404782

Abstract | Full Text | PDF

Efficacy and safety of low-dose alemtuzumab as treatment of autoimmune hemolytic anemia in pretreated B-cell chronic lymphocytic leukemia

L Laurenti, M Tarnani, D G Efremov, P Chiusolo, L De Padua, S Sica and G Leone

Leukemia 21: 1819-1821; advance online publication, April 19, 2007; doi:10.1038/sj.leu.2404703

Abstract | Full Text | PDF

Reply to 'Efficacy and safety of low-dose alemtuzumab as treatment of autoimmune hemolytic anemia in pretreated B-cell chronic lymphocytic leukemia' by Dr Laurenti et al.

J Lundin

Leukemia 21: 1821; advance online publication, April 19, 2007; doi:10.1038/sj.leu.2404704

Abstract | Full Text | PDF

Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin

A Traverse-Glehen, A Verney, L Baseggio, P Felman, E Callet-Bauchu, C Thieblemont, M Ffrench, J-P Magaud, B Coiffier, F Berger and G Salles

Leukemia 21: 1821-1824; advance online publication, May 3, 2007; doi:10.1038/sj.leu.2404706

Abstract | Full Text | PDF | Supplementary information

Concurrent JAK2(V617F) mutation and BCR-ABL translocation within committed myeloid progenitors in myelofibrosis

M Bornhäuser, B Mohr, U Oelschlaegel, P Bornhäuser, S Jacki, G Ehninger and C Thiede

Leukemia 21: 1824-1826; advance online publication, May 3, 2007; doi:10.1038/sj.leu.2404730

Abstract | Full Text | PDF

Lenalidomide therapy in del(5)(q31)-associated myelofibrosis: cytogenetic and JAK2V617F molecular remissions

A Tefferi, T L Lasho, R A Mesa, A Pardanani, R P Ketterling and C A Hanson

Leukemia 21: 1827-1828; advance online publication, April 26, 2007; doi:10.1038/sj.leu.2404711

Abstract | Full Text | PDF

JAK2V617F prevalence and allele burden in non-splanchnic venous thrombosis in the absence of overt myeloproliferative disorder

A Pardanani, T L Lasho, S Schwager, C Finke, K Hussein, R K Pruthi and A Tefferi

Leukemia 21: 1828-1829; advance online publication, April 26, 2007; doi:10.1038/sj.leu.2404710

Abstract | Full Text | PDF

Treatment of steroid-resistant acute GVHD with OKT3 and high-dose steroids results in better disease control and lower incidence of infectious complications when compared to high-dose steroids alone: a randomized multicenter trial by the EBMT Chronic Leukemia Working Party

S Knop, H Hebart, A Gratwohl, C Kliem, C Faul, E Holler, J Apperley, H J Kolb, A Schaefer, D Niederwieser and H Einsele

Leukemia 21: 1830-1833; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404731

Abstract | Full Text | PDF

Monosomy 7 in myeloid malignancies: parental origin and monitoring by real-time quantitative PCR

G Porta, E Maserati, E Mattarucchi, A Minelli, B Pressato, R Valli, M Zecca, M E Bernardo, F Lo Curto, F Locatelli, C Danesino and F Pasquali

Leukemia 21: 1833-1835; advance online publication, April 26, 2007; doi:10.1038/sj.leu.2404708

Abstract | Full Text | PDF

The HOXB4 homeoprotein improves ex vivo generation of functional human NK-cell progenitors

R Haddad, A Caignard, G Visentin, I Vigon, S Fichelson and S Amsellem

Leukemia 21: 1836-1839; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404725

Abstract | Full Text | PDF

A novel ETV6-PDGFRB fusion transcript missed by standard screening in a patient with an imatinib responsive chronic myeloproliferative disease

C E Curtis, F H Grand, K Waghorn, T P Sahoo, J George and N C P Cross

Leukemia 21: 1839-1841; advance online publication, May 17, 2007; doi:10.1038/sj.leu.2404728

Abstract | Full Text | PDF

Treatment of severe autoimmune hemolytic anemia in B-cell chronic lymphocytic leukemia with alemtuzumab

B Royer, I Vaida, A Etienne, R Garidi, G Damaj and J P Marolleau

Leukemia 21: 1841-1842; advance online publication, April 26, 2007; doi:10.1038/sj.leu.2404713

Abstract | Full Text | PDF

Reply to Rituximab activity in CD20 positive multiple myeloma

A Gozzetti, A Fabbri, S Lazzi, M Bocchia and F Lauria

Leukemia 21: 1842-1843; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404702

Abstract | Full Text | PDF

JAK2V617F as progression marker in CMPD and as cooperative mutation in AML with trisomy 8 and t(8;21): a comparative study on 1103 CMPD and 269 AML cases

S Schnittger, U Bacher, W Kern, T Haferlach and C Haferlach

Leukemia 21: 1843-1845; advance online publication, April 19, 2007; doi:10.1038/sj.leu.2404707

Abstract | Full Text | PDF

Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma

J Hiraga, A Katsumi, T Iwasaki, A Abe, H Kiyoi, T Matsushita, T Kinoshita and T Naoe

Leukemia 21: 1846-1847; advance online publication, April 19, 2007; doi:10.1038/sj.leu.2404717

Abstract | Full Text | PDF

A sub-population of high proliferative potential-quiescent human mesenchymal stem cells is under the reversible control of interferon /  FREE

I Peiffer¹, P Eid², R Barbet³, M L Li⁴, R A J Oostendorp⁵, V Haydont⁶, M-N Monier⁷, L Milon⁸, N Fortunel⁹, P Charbord¹⁰, M Tovey¹¹, J Hatzfeld¹² and A Hatzfeld¹³

Leukemia 21: 1848; doi:10.1038/sj.leu.2404765

Abstract | Full Text | PDF