TABLE OF CONTENTS
Volume 21, Issue 7 (July 2007)
Editorials
Chronic myeloid leukemia – some topical issues
T Mughal, J Cortes, N C P Cross, N Donato, O Hantschel, E Jabbour, H Kantarjian, J V Melo, T Skorski, R T Silver and J M Goldman
Leukemia 21: 1347-1352; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404733
Impact of SARS on development of childhood acute lymphoblastic leukaemia
C K Li, B Zee, J Lee, K W Chik, S Y Ha and V Lee on behalf of the Hong Kong Paediatric Haematology & Oncology Study Group
Leukemia 21: 1353-1356; doi:10.1038/sj.leu.2404729
Spotlight Review
Viewpoint: What is the role of allogeneic haematopoietic cell transplantation in the era of reduced-intensity conditioning – is there still an upper age limit? A focus on myeloid neoplasia
J Finke and A Nagler
Leukemia 21: 1357-1362; advance online publication, May 17, 2007; doi:10.1038/sj.leu.2404741
Reviews
Signal transduction pathways that contribute to myeloid differentiation
M B Miranda and D E Johnson
Leukemia 21: 1363-1377; advance online publication, April 19, 2007; doi:10.1038/sj.leu.2404690
The dynamics of the B follicle: understanding the normal counterpart of B-cell-derived malignancies
X Sagaert, B Sprangers and C De Wolf-Peeters
Leukemia 21: 1378-1386; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404737
Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond
M Mohty
Leukemia 21: 1387-1394; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404683
Original Articles
Molecular Targets for Therapy
The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-
-expressing cells through caspase-3-mediated cleavage of Mcl-1
J Pan, A Quintás-Cardama, T Manshouri, F J Giles, P Lamb, A Tefferi, J Cortes, H Kantarjian and S Verstovsek
Leukemia 21: 1395-1404; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404714
Therapy
A CD19-specific single-chain immunotoxin mediates potent apoptosis of B-lineage leukemic cells
M Schwemmlein, J Stieglmaier, C Kellner, M Peipp, D Saul, F Oduncu, B Emmerich, B Stockmeyer, P Lang, J D Beck and G H Fey
Leukemia 21: 1405-1412; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404687
Acute Leukemias
Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies
V M Guillem, M Collado, M J Terol, M J Calasanz, J Esteve, M Gonzalez, C Sanzo, J Nomdedeu, P Bolufer, A Lluch and M Tormo
Leukemia 21: 1413-1422; advance online publication, May 3, 2007; doi:10.1038/sj.leu.2404709
Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential
A M S Cheung, T S K Wan, J C K Leung, L Y Y Chan, H Huang, Y L Kwong, R Liang and A Y H Leung
Leukemia 21: 1423-1430; advance online publication, May 3, 2007; doi:10.1038/sj.leu.2404721
Childhood secondary ALL after ALL treatment
J Zuna, H Cavé, C Eckert, T Szczepanski, C Meyer, E Mejstrikova, E Fronkova, K Muzikova, E Clappier, D Mendelova, P Boutard, A Schrauder, J Sterba, R Marschalek, J J M van Dongen, O Hrusak, J Stary and J Trka
Leukemia 21: 1431-1435; advance online publication, April 26, 2007; doi:10.1038/sj.leu.2404718
Myelodysplasias
Low IPSS score and bone marrow hypocellularity in MDS patients predict hematological responses to antithymocyte globulin
Z Y Lim, S Killick, U Germing, J Cavenagh, D Culligan, A Bacigalupo, J Marsh and G J Mufti
Leukemia 21: 1436-1441; advance online publication, May 17, 2007; doi:10.1038/sj.leu.2404747
Chronic Myeloproliferative Disorders
WT1 transcript amount discriminates secondary or reactive eosinophilia from idiopathic hypereosinophilic syndrome or chronic eosinophilic leukemia
D Cilloni, F Messa, G Martinelli, E Gottardi, F Arruga, I Defilippi, S Carturan, E Messa, M Fava, E Giugliano, V Rosso, R Catalano, S Merante, P Nicoli, M Rondoni, E Ottaviani, S Soverini, M Tiribelli, F Pane, M Baccarani and G Saglio a study by the GIMEMA Working Party on Chronic Myeloid Leukemia
Leukemia 21: 1442-1450; advance online publication, May 17, 2007; doi:10.1038/sj.leu.2404670
Stem Cells
CTLA-4 blockade in murine bone marrow chimeras induces a host-derived antileukemic effect without graft-versus-host disease
S Fevery, A D Billiau, B Sprangers, O Rutgeerts, C Lenaerts, J Goebels, W Landuyt, A Kasran, L Boon, X Sagaert, C De Wolf-Peeters, M Waer and P Vandenberghe
Leukemia 21: 1451-1459; advance online publication, May 17, 2007; doi:10.1038/sj.leu.2404720
Cytogenetics and Molecular Genetics
Comparison of a quantitative PCR method with FISH for the assessment of the four aneuploidies commonly evaluated in CLL patients
C Bastard, G Raux, C Fruchart, F Parmentier, D Vaur, D Penther, X Troussard, D Nagib, S Lepretre, M Tosi, T Frebourg and H Tilly
Leukemia 21: 1460-1463; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404727
Immunology
Bortezomib significantly impairs the immunostimulatory capacity of human myeloid blood dendritic cells
C Straube, R Wehner, M Wendisch, M Bornhäuser, M Bachmann, E P Rieber and M Schmitz
Leukemia 21: 1464-1471; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404734
Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopenia
C Perry, M Pick, E Podoly, A Gilboa-Geffen, G Zimmerman, E H Sklan, Y Ben-Shaul, S Diamant and H Soreq
Leukemia 21: 1472-1480; advance online publication, May 3, 2007; doi:10.1038/sj.leu.2404722
Genomics
Characterization of a reference material for BCR-ABL (M-BCR) mRNA quantitation by real-time amplification assays: towards new standards for gene expression measurements
J Saldanha, M Silvy, N Beaufils, R Arlinghaus, G Barbany, S Branford, J-M Cayuela, G Cazzaniga, M Gonzalez, D Grimwade, V Kairisto, K Miyamura, M Lawler, T Lion, E Macintyre, F-X Mahon, M C Muller, M Ostergaard, H Pfeifer, G Saglio, C Sawyers, O Spinelli, V H J van der Velden, J Q Wang, K Zoi, V Patel, P Phillips, P Matejtschuk and J Gabert
Leukemia 21: 1481-1487; advance online publication, May 3, 2007; doi:10.1038/sj.leu.2404716
Apoptosis
Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase C
H Yan, Y-C Wang, D Li, Y Wang, W Liu, Y-L Wu and G-Q Chen
Leukemia 21: 1488-1495; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404735
The notch pathway positively regulates programmed cell death during erythroid differentiation
À Robert-Moreno, L Espinosa, M J Sanchez, J L de la Pompa and A Bigas
Leukemia 21: 1496-1503; advance online publication, May 3, 2007; doi:10.1038/sj.leu.2404705
Differentiation
Synergistic effect of AS101 and Bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model
M Hayun, E Okun, R Hayun, U Gafter, M Albeck, D L Longo and B Sredni
Leukemia 21: 1504-1513; advance online publication, May 17, 2007; doi:10.1038/sj.leu.2404746
Lymphoma
Genome-wide detection of recurring sites of uniparental disomy in follicular and transformed follicular lymphoma
J Fitzgibbon, S Iqbal, A Davies, D O'Shea, E Carlotti, T Chaplin, J Matthews, M Raghavan, A Norton, T A Lister and B D Young
Leukemia 21: 1514-1520; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404696
Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-
B (RelB/p52) in non-Hodgkin's lymphoma cells
T Lwin, L A Hazlehurst, Z Li, S Dessureault, E Sotomayor, L C Moscinski, W S Dalton and J Tao
Leukemia 21: 1521-1531; advance online publication, May 3, 2007; doi:10.1038/sj.leu.2404723
A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation
J I Martín-Subero, R Ibbotson, W Klapper, L Michaux, E Callet-Bauchu, F Berger, M J Calasanz, C De Wolf-Peeters, M J Dyer, P Felman, A Gardiner, R D Gascoyne, S Gesk, L Harder, D E Horsman, M Kneba, R Küppers, A Majid, N Parry-Jones, M Ritgen, M Salido, F Solé, G Thiel, H-H Wacker, D Oscier, I Wlodarska and R Siebert
Leukemia 21: 1532-1544; advance online publication, May 10, 2007; doi:10.1038/sj.leu.2404695
Myeloma
A different schedule of zoledronic acid can reduce the risk of the osteonecrosis of the jaw in patients with multiple myeloma
A Corso, M Varettoni, P Zappasodi, C Klersy, S Mangiacavalli, G Pica and M Lazzarino
Leukemia 21: 1545-1548; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404682
ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells
M P Kline, S V Rajkumar, M M Timm, T K Kimlinger, J L Haug, J A Lust, P R Greipp and S Kumar
Leukemia 21: 1549-1560; advance online publication, April 26, 2007; doi:10.1038/sj.leu.2404719
Letters to the Editor
Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels
N Widmer, H Rumpold, G Untergasser, A Fayet, T Buclin and L A Decosterd
Leukemia 21: 1561-1562; advance online publication, April 12, 2007; doi:10.1038/sj.leu.2404671
Reply to 'Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels' by Widmer et al.
Y Zong, S Zhou and B P Sorrentino
Leukemia 21: 1562-1563; advance online publication, April 12, 2007; doi:10.1038/sj.leu.2404672
Reply to Zong et al.
N Widmer, H Rumpold, G Untergasser, A Fayet, T Buclin and L A Decosterd
Leukemia 21: 1563-1564; advance online publication, April 12, 2007; doi:10.1038/sj.leu.2404674
A new type of NPM1 gene mutation in AML leading to a C-terminal truncated protein
A S Pitiot, I Santamaría, O García-Suárez, I Centeno, A Astudillo, C Rayón and M Balbín
Leukemia 21: 1564-1566; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404679
Cytoplasmic mutated nucleophosmin (NPM) defines the molecular status of a significant fraction of myeloid sarcomas
B Falini, D Lenze, R Hasserjian, S Coupland, D Jaehne, C Soupir, A Liso, M P Martelli, N Bolli, F Bacci, V Pettirossi, A Santucci, M F Martelli, S Pileri and H Stein
Leukemia 21: 1566-1570; advance online publication, April 19, 2007; doi:10.1038/sj.leu.2404699
Thrombosis can occur at any phase of essential thrombocythemia with JAK2V617F mutation: a single institutional study in Japan
K Ohyashiki, Y Ito, K Hori, K Sato, T Makino and J H Ohyashiki
Leukemia 21: 1570-1571; advance online publication, March 29, 2007; doi:10.1038/sj.leu.2404666
c-Maf nuclear oncoprotein is frequently expressed in multiple myeloma
Hong Chang, Q Qi, W Xu and B Patterson
Leukemia 21: 1572-1574; advance online publication, March 29, 2007; doi:10.1038/sj.leu.2404669
Quantitative profiling of codon 816 KIT mutations can aid in the classification of systemic mast cell disease
W Zhao, C E Bueso-Ramos, S Verstovsek, B A Barkoh, A A Khitamy and D Jones
Leukemia 21: 1574-1576; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404680
Remitting activity of lenalidomide in treatment-induced myelodysplastic syndrome
M Melchert, C Williams and A List
Leukemia 21: 1576-1578; advance online publication, March 29, 2007; doi:10.1038/sj.leu.2404677
Recurrent chromosomal aberration at 12q15 in chronic idiopathic myelofibrosis with or without JAK2V617F mutation
K Ohyashiki, T Tauchi, M Kuroda, A Kodama and J H Ohyashiki
Leukemia 21: 1578-1580; advance online publication, April 19, 2007; doi:10.1038/sj.leu.2404700
Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells
J Caers, S Deleu, Z Belaid, H De Raeve, E Van Valckenborgh, E De Bruyne, M-P DeFresne, I Van Riet, B Van Camp and K Vanderkerken
Leukemia 21: 1580-1584; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404658
Janus kinase mutations in the development of acute megakaryoblastic leukemia in children with and without Down's syndrome
J H Klusmann, D Reinhardt, H Hasle, G J Kaspers, U Creutzig, K Hahlen, M M van den Heuvel-Eibrink and C M Zwaan
Leukemia 21: 1584-1587; advance online publication, April 19, 2007; doi:10.1038/sj.leu.2404694
Class I HDAC SNP analysis in healthy donors compared to AML patients
C-L Dransfeld, M Schaich, A D Ho, C Thiede, G Ehninger and U Mahlknecht
Leukemia 21: 1587-1590; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404673
VEGF/PLGF induces leukemia cell migration via P38/ERK1/2 kinase pathway, resulting in Rho GTPases activation and caveolae formation
C Casalou, R Fragoso, J F M Nunes and S Dias
Leukemia 21: 1590-1594; advance online publication, March 29, 2007; doi:10.1038/sj.leu.2404668
Development of adult T-cell leukemia in donor-derived human T-cell leukemia virus type I-infected T cells after allogeneic bone marrow transplantation
H Tamaki, Y Taniguchi, A Kikuchi, T Yamagami, T Soma and M Matsuoka
Leukemia 21: 1594-1596; advance online publication, April 19, 2007; doi:10.1038/sj.leu.2404697
Effect of spacing intravenous bisphosphonates in patients with multiple myeloma in plateau phase
S Park, D Borderie, C Cormier, D Bouscary, C Roux, C Job-Deslandre, A Merlat, B Cherreau, J C Souberbielle and F Dreyfus
Leukemia 21: 1596-1599; advance online publication, April 26, 2007; doi:10.1038/sj.leu.2404715
Detecting the JAK2 V617F mutation in fresh and 'historic' blood and bone marrow
S Gattenlohner, C Peter, M Bonengel, H Einsele, R Bargou, H-K Müller-Hermelink and A Marx
Leukemia 21: 1559-1602; advance online publication, April 26, 2007; doi:10.1038/sj.leu.2404701
