TABLE OF CONTENTS
Volume 21, Issue 6 (June 2007)
Editorial
Cigarette smoking, cytogenetic abnormalities, and acute myelogenous leukemia
M A Lichtman
Leukemia 21: 1137-1140; doi:10.1038/sj.leu.2404698
Spotlight Review
Working hypothesis to redefine endothelial progenitor cells
D N Prater, J Case, D A Ingram and M C Yoder
Leukemia 21: 1141-1149; advance online publication, March 29, 2007; doi:10.1038/sj.leu.2404676
Reviews
Maintenance therapy in multiple myeloma
R Mihelic, J L Kaufman and S Lonial
Leukemia 21: 1150-1157; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404633
mRNA stability control: a clandestine force in normal and malignant hematopoiesis
R A Steinman
Leukemia 21: 1158-1171; advance online publication, March 29, 2007; doi:10.1038/sj.leu.2404656
Concise Review
ABC transporters and drug resistance in leukemia: was P-gp nothing but the first head of the Hydra?
D Steinbach and O Legrand
Leukemia 21: 1172-1176; advance online publication, April 12, 2007; doi:10.1038/sj.leu.2404692
Original Articles
Acute Leukemias
The quality of molecular response to chemotherapy is predictive for the outcome of AML1-ETO-positive AML and is independent of pretreatment risk factors
M Weisser, C Haferlach, W Hiddemann and S Schnittger
Leukemia 21: 1177-1182; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404659
Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associated acute myeloid leukemia and lymphoblastic T-cell lymphoma
G Metzgeroth, C Walz, J Score, R Siebert, S Schnittger, C Haferlach, H Popp, T Haferlach, P Erben, J Mix, M C Müller, H Beneke, L Müller, F Del Valle, W E Aulitzky, G Wittkowsky, N Schmitz, C Schulte, K Müller-Hermelink, E Hodges, S J Whittaker, F Diecker, H Döhner, P Schuld, R Hehlmann, A Hochhaus, N C P Cross and A Reiter
Leukemia 21: 1183-1188; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404662
Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells
B Zhang, J Groffen and N Heisterkamp
Leukemia 21: 1189-1197; advance online publication, March 29, 2007; doi:10.1038/sj.leu.2404667
Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status
A Andersson, C Ritz, D Lindgren, P Edén, C Lassen, J Heldrup, T Olofsson, J Råde, M Fontes, A Porwit-MacDonald, M Behrendtz, M Höglund, B Johansson and T Fioretos
Leukemia 21: 1198-1203; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404688
Discriminant function analysis as decision support system for the diagnosis of acute leukemia with a minimal four color screening panel and multiparameter flow cytometry immunophenotyping
R Ratei, L Karawajew, F Lacombe, K Jagoda, G D Poeta, J Kraan, M De Santiago, J Kappelmayer, E Björklund, W-D Ludwig, J W Gratama and A Orfao for the European Working Group of Clinical Cell Analysis (EWGCCA)
Leukemia 21: 1204-1211; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404675
Small number of HTLV-1-positive cells frequently remains during complete remission after allogeneic hematopoietic stem cell transplantation that are heterogeneous in origin among cases with adult T-cell leukemia/lymphoma
R Yamasaki, Y Miyazaki, Y Moriuchi, C Tsutsumi, T Fukushima, S Yoshida, J Taguchi, Y Inoue, E Matsuo, Y Imaizumi, D Imanishi, T Fujimoto, H Tsushima, S Honda, T Hata, K Tsukasaki and M Tomonaga
Leukemia 21: 1212-1217; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404678
Chronic Myeloproliferative Disorders
Essential thrombocythemia in young individuals: frequency and risk factors for vascular events and evolution to myelofibrosis in 126 patients
A Alvarez-Larrán, F Cervantes, B Bellosillo, M Giralt, A Juliá, J C Hernández-Boluda, A Bosch, L Hernández-Nieto, V Clapés, C Burgaleta, C Salvador, E Arellano-Rodrigo, D Colomer and C Besses
Leukemia 21: 1218-1223; advance online publication, April 12, 2007; doi:10.1038/sj.leu.2404693
Cytogenetics and Molecular Genetics
DNA profiling analysis of 100 consecutive de novo acute myeloid leukemia cases reveals patterns of genomic instability that affect all cytogenetic risk groups
J Suela, S Álvarez, F Cifuentes, C Largo, B I Ferreira, D Blesa, M Ardanaz, R García, J A Marquez, M D Odero, M J Calasanz and J C Cigudosa
Leukemia 21: 1224-1231; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404653
Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4
MLL fusion allele
E Kowarz, T Burmeister, L Lo Nigro, M W J C Jansen, E Delabesse, T Klingebiel, Theo Dingermann, C Meyer and R Marschalek
Leukemia 21: 1232-1238; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404686
Stem Cells
Mouse embryonic stem cells that express a NUP98–HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL
C Slape, Y J Chung, P D Soloway, L Tessarollo and P D Aplan
Leukemia 21: 1239-1248; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404648
CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment
J Juarez, A Dela Pena, R Baraz, J Hewson, M Khoo, A Cisterne, S Fricker, N Fujii, K F Bradstock and L J Bendall
Leukemia 21: 1249-1257; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404684
Genomics
High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression
R P Kuiper, E F P M Schoenmakers, S V van Reijmersdal, J Y Hehir-Kwa, A Geurts van Kessel, F N van Leeuwen and P M Hoogerbrugge
Leukemia 21: 1258-1266; advance online publication, April 19, 2007; doi:10.1038/sj.leu.2404691
Sensitivity and Resistance to Therapy
Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells
C Brendel, C Scharenberg, M Dohse, R W Robey, S E Bates, S Shukla, S V Ambudkar, Y Wang, G Wennemuth, A Burchert, U Boudriot and A Neubauer
Leukemia 21: 1267-1275; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404638
Lymphomas
Gene expression profiling of precursor T-cell lymphoblastic leukemia/lymphoma identifies oncogenic pathways that are potential therapeutic targets
Y-W Lin and P D Aplan
Leukemia 21: 1276-1284; advance online publication, April 12, 2007; doi:10.1038/sj.leu.2404685
Junctional adhesion molecule C (JAM-C) distinguishes CD27+ germinal center B lymphocytes from non-germinal center cells and constitutes a new diagnostic tool for B-cell malignancies
C Ody, S Jungblut-Ruault, D Cossali, M Barnet, M Aurrand-Lions, B A Imhof and T Matthes
Leukemia 21: 1285-1293; advance online publication, April 12, 2007; doi:10.1038/sj.leu.2404689
Myeloma
Thalidomide in newly diagnosed multiple myeloma: influence of thalidomide treatment on peripheral blood stem cell collection yield
I Breitkreutz, H M Lokhorst, M S Raab, B van der Holt, F W Cremer, D Herrmann, A Glasmacher, I G H Schmidt-Wolf, I W Blau, H Martin, H Salwender, A Haenel, P Sonneveld and H Goldschmidt
Leukemia 21: 1294-1299; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404661
Letters to the Editor
Inhibition of myc promoter and telomerase activity and induction of delayed apoptosis by SYUIQ-5, a novel G-quadruplex interactive agent in leukemia cells
J-N Liu, R Deng, J-F Guo, J-M Zhou, G-K Feng, Z-S Huang, L-Q Gu, Y-X Zeng and X-F Zhu
Leukemia 21: 1300-1302; advance online publication, March 29, 2007; doi:10.1038/sj.leu.2404652
Clonal duplication of a germline PTPN11 mutation due to acquired uniparental disomy in acute lymphoblastic leukemia blasts from a patient with Noonan syndrome
A Karow, D Steinemann, G Göhring, H Hasle, J Greiner, A Harila-Saari, C Flotho, M Zenker, B Schlegelberger, C M Niemeyer and C P Kratz
Leukemia 21: 1303-1305; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404651
CD7/CD56-positive acute myeloid leukemias are characterized by constitutive phosphorylation of the NF-kB subunit p65 at Ser536
A Morotti, G Parvis, D Cilloni, U Familiari, M Pautasso, M Bosa, F Messa, F Arruga, I Defilippi, R Catalano, V Rosso, S Carturan, E Bracco, A Guerrasio and G Saglio
Leukemia 21: 1305-1306; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404581
No nucleophosmin mutations in pediatric acute myeloid leukemia with normal karyotype: a study of the Japanese Childhood AML Cooperative Study Group
A Shimada, T Taki, C Kubota, A Tawa, K Horibe, M Tsuchida, R Hanada, I Tsukimoto and Y Hayashi
Leukemia 21: 1307; advance online publication, February 22, 2007; doi:10.1038/sj.leu.2404625
ZD6474 induces growth arrest and apoptosis of human leukemia cells, which is enhanced by concomitant use of a novel MEK inhibitor, AZD6244
C Nishioka, T Ikezoe, A Takeshita, J Yang, T Tasaka, Y Yang, Y Kuwayama, N Komatsu, K Togitani, H P Koeffler and H Taguchi
Leukemia 21: 1308-1310; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404647
Bevacizumab reduces VEGF expression in patients with relapsed and refractory acute myeloid leukemia without clinical antileukemic activity
L Zahiragic, C Schliemann, R Bieker, N H Thoennissen, K Burow, C Kramer, M Zühlsdorf, W E Berdel and R M Mesters
Leukemia 21: 1310-1312; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404632
Angiopoietin-2 expression in B-cell chronic lymphocytic leukemia: association with clinical outcome and immunoglobulin heavy-chain mutational status
R Maffei, R Marasca, S Martinelli, I Castelli, R Santachiara, E Morandi, P Zucchini, M Fontana, F Giacobbi, P Silingardi, G Bonacorsi, P Temperani, L Masini, A M Colacci, R Serra and G Torelli
Leukemia 21: 1312-1315; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404650
Germline mutations in SPI1 and MADD do not contribute to familial chronic lymphocytic leukaemia
G S Sellick, M Qureshi, S Fielding, D Catovsky and R S Houlston
Leukemia 21: 1315-1318; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404646
High-throughput, sensitive and quantitative assay for the detection of BCR-ABL kinase domain mutations
A Vivante, N Amariglio, M Koren-Michowitz, O Ashur-Fabian, A Nagler, G Rechavi and Y Cohen
Leukemia 21: 1318-1321; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404635
The outcome of intensive induction therapy in patients 
70 years with acute myeloid leukemia
V Gupta, W Xu, C Keng, S M H Alibhai, J Brandwein, A Schimmer, A Schuh, K Yee and M D Minden
Leukemia 21: 1321-1324; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404655
Paracrine promotion of tumor development by the TNF ligand APRIL in Hodgkin's Disease
J Schwaller, P Went, T Matthes, S Dirnhofer, O Donze, P Mhawech-Fauceglia, S Myit and B Huard
Leukemia 21: 1324-1327; advance online publication, February 22, 2007; doi:10.1038/sj.leu.2404627
Tiling-resolution array-CGH reveals the pattern of DNA copy number alterations in acute lymphoblastic leukemia with 21q amplification: the result of telomere dysfunction and breakage/fusion/breakage cycles?
E Kuchinskaya, A Nordgren, M Heyman, J Schoumans, M Corcoran, J Staaf, Å Borg, S Söderhäll, D Grandér, M Nordenskjöld and E Blennow
Leukemia 21: 1327-1330; advance online publication, February 22, 2007; doi:10.1038/sj.leu.2404628
A higher JAK2 V617F-mutated clone is observed in platelets than in granulocytes from essential thrombocythemia patients, but not in patients with polycythemia vera and primary myelofibrosis
B Bellosillo, L Martínez-Avilés, E Gimeno, L Florensa, R Longarón, G Navarro, A Salar, B Espinet, F Solé, S Serrano and C Besses
Leukemia 21: 1331-1332; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404649
Analysis of chromosome copy number in leukemic cells by different microarray platforms
Y Yamashita, K Minoura, T Taya, S-i Fujiwara, K Kurashina, H Watanabe, Y L Choi, M Soda, H Hatanaka, M Enomoto, S Takada and H Mano
Leukemia 21: 1333-1337; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404636
Expression of the JAK2 V617F mutation is not found in de novo AML and MDS but is detected in MDS-derived leukemia of megakaryoblastic nature
K Nishii, R Nanbu, F Lorenzo V, F Monma, K Kato, H Ryuu and N Katayama
Leukemia 21: 1337-1338; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404626
Quantification of ex vivo generated dendritic cells (DC) and leukemia-derived DC contributes to estimate the quality of DC, to detect optimal DC-generating methods or to optimize DC-mediated T-cell-activation-procedures ex vivo or in vivo
H M Schmetzer, A Kremser, J Loibl, T Kroell and H-J Kolb
Leukemia 21: 1338-1341; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404639
Gene expression overlap affects karyotype prediction in pediatric acute lymphoblastic leukemia
S B Martin, M P Mosquera-Caro, J W Potter, G S Davidson, E Andries, H Kang, P Helman, R L Veroff, S R Atlas, M Murphy, X Wang, K Ar, Y Xu, I-M Chen, F A Schultz, C S Wilson, R Harvey, E Bedrick, J Shuster, A J Carroll, B Camitta and C L Willman
Leukemia 21: 1341-1344; advance online publication, April 5, 2007; doi:10.1038/sj.leu.2404640
CT mutation at nucleotides 1848–1849: diagnostic implication