Chronic graft-versus-host disease in the era of reduced-intensity conditioning

D S Subramaniam, D H Fowler and S Z Pavletic

Leukemia 21: 853-859; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404642

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A hypothesis for an embryonic origin of pluripotent Oct-4⁺ stem cells in adult bone marrow and other tissues

M Z Ratajczak, B Machalinski, W Wojakowski, J Ratajczak and M Kucia

Leukemia 21: 860-867; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404630

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A tumor suppressor and oncogene: the WT1 story FREE

L Yang, Y Han, F Saurez Saiz and M D Minden

Leukemia 21: 868-876; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404624

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Molecular Targets for Therapy

AS602868, a dual inhibitor of IKK2 and FLT3 to target AML cells

E Griessinger, V Imbert, P Lagadec, N Gonthier, P Dubreuil, A Romanelli, M Dreano and J-F Peyron

Leukemia 21: 877-885; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404614

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The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion

P L Tazzari, G Tabellini, R Bortul, V Papa, C Evangelisti, T Grafone, G Martinelli, J A McCubrey and A M Martelli

Leukemia 21: 886-896; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404643

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Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia

P Rhein, S Scheid, R Ratei, C Hagemeier, K Seeger, R Kirschner-Schwabe, A Moericke, M Schrappe, R Spang, W-D Ludwig and L Karawajew

Leukemia 21: 897-905; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404613

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Aberrant DNA methylation of the Src kinase Hck, but not of Lyn, in Philadelphia chromosome negative acute lymphocytic leukemia

K Hoshino, A Quintás-Cardama, H Yang, B Sanchez-Gonzalez and G Garcia-Manero

Leukemia 21: 906-911; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404615

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MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis FREE

S Debernardi, S Skoulakis, G Molloy, T Chaplin, A Dixon-McIver and B D Young

Leukemia 21: 912-916; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404605

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Chronic Myeloproliferative Disorders

p210^BCR-ABL reprograms transformed and normal human megakaryocytic progenitor cells into erythroid cells and suppresses FLI-1 transcription

D Buet, H Raslova, J-F Geay, P Jarrier, V Lazar, A Turhan, F Morlé, W Vainchenker and F Louache

Leukemia 21: 917-925; advance online publication, February 22, 2007; doi:10.1038/sj.leu.2404600

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Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies

X Jiang, Y Zhao, C Smith, M Gasparetto, A Turhan, A Eaves and C Eaves

Leukemia 21: 926-935; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404609

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The anticancer drug imatinib induces cellular autophagy

A Ertmer, V Huber, S Gilch, T Yoshimori, V Erfle, J Duyster, H-P Elsässer and H M Schätzl

Leukemia 21: 936-942; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404606

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Response to donor lymphocyte infusions for chronic myeloid leukemia is dose-dependent: the importance of escalating the cell dose to maximize therapeutic efficacy

M P Simula, S Marktel, C Fozza, J Kaeda, R M Szydlo, E Nadal, M Bua, A Rahemtulla, E Kanfer, D Marin, E Olavarria, J M Goldman, J F Apperley and F Dazzi

Leukemia 21: 943-948; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404641

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Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression

A Sengupta, D Banerjee, S Chandra, S K Banerji, R Ghosh, R Roy and S Banerjee

Leukemia 21: 949-955; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404657

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Chronic Lymphocytic Leukemia

International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia

A C Rawstron, N Villamor, M Ritgen, S Böttcher, P Ghia, J L Zehnder, G Lozanski, D Colomer, C Moreno, M Geuna, P A S Evans, Y Natkunam, S E Coutre, E D Avery, L Z Rassenti, T J Kipps, F Caligaris-Cappio, M Kneba, J C Byrd, M J Hallek, E Montserrat and P Hillmen

Leukemia 21: 956-964; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404584

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Telomerase expression in B-cell chronic lymphocytic leukemia predicts survival and delineates subgroups of patients with the same igVH mutation status and different outcome

L Terrin, L Trentin, M Degan, I Corradini, R Bertorelle, P Carli, N Maschio, M D Bo, F Noventa, V Gattei, G Semenzato and A De Rossi

Leukemia 21: 965-972; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404607

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Cleavage fragments of the third complement component (C3) enhance stromal derived factor-1 (SDF-1)-mediated platelet production during reactive postbleeding thrombocytosis

M Wysoczynski, M Kucia, J Ratajczak and M Z Ratajczak

Leukemia 21: 973-982; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404629

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Telomere length of cord blood-derived CD34⁺ progenitors predicts erythroid proliferative potential

C E Schuller, K Jankowski and K L MacKenzie

Leukemia 21: 983-991; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404631

Abstract | Full Text | PDF | Supplementary information

Cytogenetics and Molecular Genetics

Unbalanced translocation der(1;7)(q10;p10) defines a unique clinicopathological subgroup of myeloid neoplasms

M Sanada, N Uike, K Ohyashiki, K Ozawa, W Lili, A Hangaishi, Y Kanda, S Chiba, M Kurokawa, M Omine, K Mitani and S Ogawa

Leukemia 21: 992-997; advance online publication, February 22, 2007; doi:10.1038/sj.leu.2404619

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Minimal Residual Disease

Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations

W-C Chou, J-L Tang, S-J Wu, W Tsay, M Yao, S-Y Huang, K-C Huang, C-Y Chen, C-F Huang and H-F Tien

Leukemia 21: 998-1004; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404637

Abstract | Full Text | PDF | Supplementary information

Oncogenes, Fusion Genes and Tumor Suppressor Genes

Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines

Y Furukawa, H A Vu, M Akutsu, T Odgerel, T Izumi, S Tsunoda, Y Matsuo, K Kirito, Y Sato, H Mano and Y Kano

Leukemia 21: 1005-1014; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404593

Abstract | Full Text | PDF | Supplementary information

Transcriptional Control and Deregulation

A novel transcript of the LMO2 gene, LMO2-c, is regulated by GATA-1 and PU.1 and encodes an antagonist of LMO2

Q Wang, M Zhang, X Wang, W Yuan, D Chen, B Royer-Pokora and T Zhu

Leukemia 21: 1015-1025; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404644

Abstract | Full Text | PDF | Supplementary information

Discovery of epigenetically silenced genes in acute myeloid leukemias

J C Desmond, S Raynaud, E Tung, W-K Hofmann, T Haferlach and H P Koeffler

Leukemia 21: 1026-1034; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404611

Abstract | Full Text | PDF | Supplementary information

Apoptosis

Smac-mediated sensitization of human B-lymphoma cells to staurosporine- and lactacystin-triggered apoptosis is apoptosome-dependent FREE

Y Sun, A Ottosson, S Pervaiz and B Fadeel

Leukemia 21: 1035-1043; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404660

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Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-B signal pathway

C Nishioka, T Ikezoe, J Yang, H P Koeffler and H Taguchi

Leukemia 21: 1044-1049; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404622

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Differentiation

Lentiviral PU.1 overexpression restores differentiation in myeloid leukemic blasts

S Durual, A Rideau, S Ruault-Jungblut, D Cossali, P Beris, V Piguet and T Matthes

Leukemia 21: 1050-1059; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404645

Abstract | Full Text | PDF | Supplementary information

Lymphoma

Genotypic evaluation of killer immunoglobulin-like receptors in NK-type lymphoproliferative disease of granular lymphocytes

E Scquizzato, A Teramo, M Miorin, M Facco, F Piazza, F Noventa, L Trentin, C Agostini, R Zambello and G Semenzato

Leukemia 21: 1060-1069; advance online publication, March 15, 2007; doi:10.1038/sj.leu.2404634

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Myeloma

Significant impact of survivin on myeloma cell growth

M Romagnoli, V Trichet, C David, M Clément, P Moreau, R Bataille and S Barillé-Nion

Leukemia 21: 1070-1078; advance online publication, February 22, 2007; doi:10.1038/sj.leu.2404602

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Bone marrow mesenchymal stem cells are abnormal in multiple myeloma

J Corre, K Mahtouk, M Attal, M Gadelorge, A Huynh, S Fleury-Cappellesso, C Danho, P Laharrague, B Klein, T Rème and P Bourin

Leukemia 21: 1079-1088; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404621

Abstract | Full Text | PDF | Supplementary information

Treatment of low-risk myelodysplastic syndromes with high-dose daily oral cholecalciferol (2000–4000 IU vitamin D₃)

I Molnár, N Stark, J Lovato, B L Powell, J Cruz, D D Hurd, J S Mathieu, T C Chen, M F Holick, S Cambra, R P McQuellon and G G Schwartz

Leukemia 21: 1089-1092; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404601

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Un-mutated IgVH in chronic lymphocytic leukemia is associated with a higher risk of immune thrombocytopenia

C Visco, I Giaretta, M Ruggeri, D Madeo, A Tosetto and F Rodeghiero

Leukemia 21: 1092-1093; advance online publication, February 15, 2007; doi:10.1038/sj.leu.2404592

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A microarray study of altered gene expression after cytarabine resistance in acute myeloid leukemia

B Yin, M L Tsai, D E Hasz, S K Rathe, M M Le Beau and D A Largaespada

Leukemia 21: 1093-1097; advance online publication, February 15, 2007; doi:10.1038/sj.leu.2404595

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JAK2^V617F mutational status as determined by semiquantitative sequence-specific primer-single molecule fluorescence detection assay is linked to clinical features in chronic myeloproliferative disorders

K Ohyashiki, Y Aota, D Akahane, A Gotoh and J H Ohyashiki

Leukemia 21: 1097-1099; advance online publication, February 22, 2007; doi:10.1038/sj.leu.2404604

Abstract | Full Text | PDF | Supplementary information

Identification and functional characterization of a cytoplasmic nucleophosmin leukaemic mutant generated by a novel exon-11 NPM1 mutation

E Albiero, D Madeo, N Bolli, I Giaretta, E Di Bona, M F Martelli, I Nicoletti, F Rodeghiero and B Falini

Leukemia 21: 1099-1103; advance online publication, February 15, 2007; doi:10.1038/sj.leu.2404597

Abstract | Full Text | PDF | Supplementary information

Polycythemia associated with the JAK2V617F mutation emerged during treatment of chronic myelogenous leukemia

M Inami, K Inokuchi, M Okabe, F Kosaka, Y Mitamura, H Yamaguchi and K Dan

Leukemia 21: 1103-1104; advance online publication, February 15, 2007; doi:10.1038/sj.leu.2404591

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Fusion of FIP1L1 and RARA as a result of a novel t(4;17)(q12;q21) in a case of juvenile myelomonocytic leukemia

A Buijs and M Bruin

Leukemia 21: 1104-1108; advance online publication, February 15, 2007; doi:10.1038/sj.leu.2404596

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Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia

C P Kratz, C M Niemeyer, C Thomas, S Bauhuber, V Matejas, E Bergsträsser, C Flotho, N J Flores, O Haas, H Hasle, M M van den Heuvel-Eibrink, R S Kucherlapati, P Lang, A E Roberts, J Starý, B Strahm, K D Swanson, M Trebo, M Zecca, B Neel, F Locatelli, M L Loh and M Zenker on behalf of the European Working Group on Childhood MDS (EWOG-MDS)

Leukemia 21: 1108-1109; advance online publication, February 22, 2007; doi:10.1038/sj.leu.2404620

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CD44 deficiency is a consistent finding in childhood Burkitt's lymphoma and leukemia

A Attarbaschi, G Mann, A Schumich, M König, W F Pickl, O A Haas, H Gadner and M N Dworzak on behalf of the Austrian Berlin–Frankfurt–Münster (BFM) Cooperative Study Group

Leukemia 21: 1110-1113; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404608

Abstract | Full Text | PDF

Transcriptional features of multiple myeloma patients with chromosome 1q gain

S Fabris, D Ronchetti, L Agnelli, L Baldini, F Morabito, S Bicciato, D Basso, K Todoerti, L Lombardi, G Lambertenghi-Deliliers and A Neri

Leukemia 21: 1113-1116; advance online publication, February 22, 2007; doi:10.1038/sj.leu.2404616

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Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis in patients with acute myeloid leukemia

M Chowdhury, K Mihara, S Yasunaga, M Ohtaki, Y Takihara and A Kimura

Leukemia 21: 1116-1122; advance online publication, March 22, 2007; doi:10.1038/sj.leu.2404623

Abstract | Full Text | PDF | Supplementary information

Are genotypes of glutathione S-transferase superfamily a risk factor for childhood acute lymphoblastic leukemia? Results of an Italian case–control study

S Pigullo, R Haupt, C Dufour, P Di Michele, M G Valsecchi, G Basso, C Rizzari, A Biondi and M Lanciotti

Leukemia 21: 1122-1124; advance online publication, February 22, 2007; doi:10.1038/sj.leu.2404617

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Expression and mutation status of candidate kinases in multiple myeloma

J O Claudio, F Zhan, L Zhuang, R Khaja, Y X Zhu, K Sivananthan, S Trudel, E Masih-Khan, R Fonseca, P L Bergsagel, S W Scherer, J Shaughnessy and A K Stewart

Leukemia 21: 1124-1127; advance online publication, March 8, 2007; doi:10.1038/sj.leu.2404612

Abstract | Full Text | PDF | Supplementary information

Comparison of whole blood vs purified blood granulocytes for the detection and quantitation of JAK2^V617F

S Hermouet, I Dobo, E Lippert, M-C Boursier, L Ergand, F Perrault-Hu and D Pineau

Leukemia 21: 1128-1130; advance online publication, February 15, 2007; doi:10.1038/sj.leu.2404588

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Quercetin enhances CD95- and TRAIL-induced apoptosis in leukemia cell lines

M Russo, P Nigro, R Rosiello, R D'Arienzo and G L Russo

Leukemia 21: 1130-1133; advance online publication, March 1, 2007; doi:10.1038/sj.leu.2404610

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International uniform response criteria for multiple myeloma FREE

B G M Durie¹, J-L Harousseau², J S Miguel³, J Bladé⁴, B Barlogie⁵, K Anderson⁶, M Gertz⁷, M Dimopoulos⁸, J Westin⁹, P Sonneveld¹⁰, H Ludwig¹¹, G Gahrton¹², M Beksac¹³, J Crowley¹⁴, A Belch¹⁵, M Boccadaro¹⁶, I Turesson¹⁷, D Joshua¹⁸, D Vesole¹⁹, R Kyle⁷, R Alexanian²⁰, G Tricot⁵, M Attal²¹, G Merlini²², R Powles²³, P Richardson²⁴, K Shimizu²⁵, P Tosi²⁶, G Morgan²⁷ and S V Rajkumar⁷ on behalf of the International Myeloma Working Group²⁹

Leukemia 21: 1134; doi:10.1038/sj.leu.2404582

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Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia FREE

N I Noguera, E Ammatuna, D Zangrilli, S Lavorgna, M Divona, F Buccisano, S Amadori, C Mecucci, B Falini and F Lo-Coco

Leukemia 21: 1135; doi:10.1038/sj.leu.2404664

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A unified definition of clinical resistance/intolerance to hydroxyurea in essential thrombocythemia: results of a consensus process by an international working group FREE

G Barosi, C Besses, G Birgegard, J Briere, F Cervantes, G Finazzi, H Gisslinger, M Griesshammer, L Gugliotta, C Harrison, H Hasselbalch, E Lengfelder, J T Reilly, J J Michiels and T Barbui

Leukemia 21: 1136; doi:10.1038/sj.leu.2404665

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Deletion of 11q23 is a highly specific nonrandom secondary genetic abnormality of ETV6/RUNX1-rearranged childhood acute lymphoblastic leukaemia FREE

A Attarbaschi, G Mann, S Strehl, M König, M Steiner, V Jeitler, Th Lion, M N Dworzak, H Gadner and O A Haas

Leukemia 21: 1137; doi:10.1038/sj.leu.2404663

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