Leukemia

FIGURE 2

FROM:

Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients

S A Pileri, S Ascani, M C Cox, C Campidelli, F Bacci, M Piccioli, P P Piccaluga, C Agostinelli, S Asioli, D Novero, M Bisceglia, M Ponzoni, A Gentile, P Rinaldi, V Franco, D Vincelli, A Pileri Jr, R Gasbarra, B Falini, P L Zinzani and M Baccarani

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Figure 2.

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(a, b) in a myelo-monocytic MS, the opposite patterns observed with the anti-MPO and CD68PG-M1 antibodies (APAAP-IHC+GHC; times 300); (c) diffuse CD99 positivity (APAAP-IHC+GHC; times 400); (d–f) range of results observed at CD56 determination. Note the internal controls (arrowed) represented by ganglion cells in d and a nerve in f (APAAP-IHC+GHC; times 300); (g) dot-like keratin expression in a MS of the left testis followed an embryonic carcinoma of the contro-lateral organ (APAAP-IHC+GHC; times 600); (h) MS cells are negative at the search for BSAP that is expressed by a residual follicle (arrowed) (APAAP-IHC+GHC; times 150); (i) interphase FISH analysis with the MLL dual color: break apart rearrangement probe in a sample with MLL gene rearrangement; arrows: the MLL gene appears splitted (one red and one green signal lay apart in the nuclei); arrow-heads: the MLL gene is not rearranged (red and green spots co-localize into two fusion red/green signal); the rectangle limits a perfectly on-focus area; (j) interphase FISH analysis with the AML1/ETO dual color: dual fusion translocation probe in a sample showing AML1/ETO gene fusion; arrow: AML1/ETO gene fusion (one red/green fusion signal, two red and two green spots, this is a less common pattern of AML1/ETO genes fusion); arrow-head: a normal cell (two green and two red spots); (k) interphase FISH analysis with the MLL dual color: break apart rearrangement probe in a sample with trisomy 11 (three red/green fusion spots); the rectangle limits a perfectly on-focus area; (l) interphase FISH analysis with the chromosome 4 centromeric (Alfa-Satellite). Spectrum green probe: three trisomic and one disomic cells are shown; arrow: not evaluable cell (NE).

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