Volume 21, Issue 11 (November 2007)



Defects of immune surveillance offer new insights into the pathophysiology and therapy of myelodysplastic syndromes FREE

J-J Kiladjian, P Fenaux and A Caignard

Leukemia 21: 2237-2239; doi:10.1038/sj.leu.2404868


Original Articles


Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia FREE

J F DiJoseph, M M Dougher, D C Armellino, D Y Evans and N K Damle

Leukemia 21: 2240-2245; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404866

Acute Leukemias

Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD FREE

Y Lu, J Kitaura, T Oki, Y Komeno, K Ozaki, M Kiyono, H Kumagai, H Nakajima, T Nosaka, H Aburatani and T Kitamura

Leukemia 21: 2246-2257; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404883

Outcome of risk-based therapy for infant acute lymphoblastic leukemia with or without an MLL gene rearrangement, with emphasis on late effects: a final report of two consecutive studies, MLL96 and MLL98, of the Japan Infant Leukemia Study Group FREE

D Tomizawa, K Koh, T Sato, N Kinukawa, A Morimoto, K Isoyama, Y Kosaka, T Oda, M Oda, Y Hayashi, M Eguchi, K Horibe, T Nakahata, S Mizutani and E Ishii

Leukemia 21: 2258-2263; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404903

Acute bilineal leukemia: a rare disease with poor outcome FREE

E G Weir, M Ali Ansari-Lari, D A S Batista, C A Griffin, S Fuller, B D Smith and M J Borowitz

Leukemia 21: 2264-2270; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404848

Stem Cells

Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon FREE

O Ringdén, M Uzunel, B Sundberg, L Lönnies, S Nava, J Gustafsson, L Henningsohn and K Le Blanc

Leukemia 21: 2271-2276; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404833

Normal Hemopoiesis

Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic mice FREE

C-Y Li, Y-Q Zhan, W Li, C-W Xu, W-X Xu, D-H Yu, R-Y Peng, Y-F Cui, X Yang, N Hou, Y-H Li, B Dong, H-B Sun and X-M Yang

Leukemia 21: 2277-2286; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404901


Clinical evaluation of BCR-ABL peptide immunisation in chronic myeloid leukaemia: results of the EPIC study FREE

J M Rojas, K Knight, L Wang and R E Clark

Leukemia 21: 2287-2295; advance online publication, July 19, 2007; doi:10.1038/sj.leu.2404858

Genomics, Gene Therapy and Proteomics

Association of heparanase gene (HPSE) single nucleotide polymorphisms with hematological malignancies FREE

O Ostrovsky, M Korostishevsky, I Levite, M Leiba, H Galski, I Vlodavsky and A Nagler

Leukemia 21: 2296-2303; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404821

Transcriptional Control and Deregulation, Signal Transduction and Cytokines

Human telomerase is regulated by erythropoietin and transforming growth factor-beta in human erythroid progenitor cells FREE

N Prade-Houdellier, E Frébet, C Demur, E-F Gautier, F Delhommeau, A-L Bennaceur-Griscelli, C Gaudin, V Martinel, G Laurent, V Mansat-De Mas and O Beyne-Rauzy

Leukemia 21: 2304-2310; advance online publication, August 23, 2007; doi:10.1038/sj.leu.2404874


UGT1A1 promoter polymorphism increases risk of nilotinib-induced hyperbilirubinemia FREE

J B Singer, Y Shou, F Giles, H M Kantarjian, Y Hsu, A S Robeva, P Rae, A Weitzman, J M Meyer, M Dugan and O G Ottmann

Leukemia 21: 2311-2315; advance online publication, July 5, 2007; doi:10.1038/sj.leu.2404827


Allogeneic stem cell transplantation following reduced-intensity conditioning can induce durable clinical and molecular remissions in relapsed lymphomas: pre-transplant disease status and histotype heavily influence outcome FREE

P Corradini, A Dodero, L Farina, R Fanin, F Patriarca, R Miceli, P Matteucci, M Bregni, R Scimè, F Narni, E Pogliani, A Locasciulli, R Milani, C Carniti, A Bacigalupo, A Rambaldi, F Bonifazi, A Olivieri, A M Gianni and C Tarella on behalf of Gruppo Italiano Trapianto di Midollo Osseo (GITMO)

Leukemia 21: 2316-2323; advance online publication, June 28, 2007; doi:10.1038/sj.leu.2404822

Long-term follow-up of high-dose treatment with autologous haematopoietic progenitor cell support in 693 patients with follicular lymphoma: an EBMT registry study FREE

S Montoto, C Canals, A Z S Rohatiner, G Taghipour, A Sureda, N Schmitz, C Gisselbrecht, L Fouillard, N Milpied, C Haioun, S Slavin, E Conde, C Fruchart, A Ferrant, V Leblond, H Tilly, T A Lister and A H Goldstone for the EBMT Lymphoma Working Party

Leukemia 21: 2324-2331; advance online publication, July 19, 2007; doi:10.1038/sj.leu.2404850

Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma FREE

J Iqbal, T C Greiner, K Patel, B J Dave, L Smith, J Ji, G Wright, W G Sanger, D L Pickering, S Jain, D E Horsman, Y Shen, K Fu, D D Weisenburger, C P Hans, E Campo, R D Gascoyne, A Rosenwald, E S Jaffe, J Delabie, L Rimsza, G Ott, H K Müller-Hermelink, J M Connors, J M Vose, T McKeithan, L M Staudt and W C Chan for the Leukemia/Lymphoma Molecular Profiling Project (LLMPP)

Leukemia 21: 2332-2343; advance online publication, July 12, 2007; doi:10.1038/sj.leu.2404856

Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells FREE

T Sanda, T Okamoto, Y Uchida, H Nakagawa, S Iida, S Kayukawa, T Suzuki, T Oshizawa, T Suzuki, N Miyata and R Ueda

Leukemia 21: 2344-2353; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404902


Letters to the Editor

The effects of CpG ODN on CLL proliferation, apoptosis or phenotype could have an impact on its clinical utility FREE

B Jahrsdorfer, S Blackwell and G Weiner

Leukemia 21: 2354-2355; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404870

Reply to 'Jahrsdorfer et al.' FREE

P G Longo, S Gobessi and D G Efremov

Leukemia 21: 2355-2356; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404871

A large exon 6 break in V-form acute promyelocytic leukemia: relevance to clinical management FREE

E Bussaglia, R Guardia and J F Nomdedéu

Leukemia 21: 2356-2357; advance online publication, June 14, 2007; doi:10.1038/sj.leu.2404799

Diagnostic evaluation of t(4;14) in multiple myeloma and evidence for clonal evolution FREE

A K Stewart, H Chang, S Trudel, K C Anderson, P Richardson, M Alsina, D Reece, S Young, A Sable-Hunt, Z Li, J Keats, S Van Wier, G Ahmann, T Price-Troska, K Giusti, P L Bergsagel, M Chesi and R Fonseca

Leukemia 21: 2358-2359; advance online publication, June 14, 2007; doi:10.1038/sj.leu.2404800

Gene expression profiling separates chronic myelomonocytic leukemia in two molecular subtypes FREE

V Gelsi-Boyer, N Cervera, F Bertucci, V Trouplin, V Remy, S Olschwang, M Chaffanet, N Vey, M-J Mozziconacci and D Birnbaum

Leukemia 21: 2359-2362; advance online publication, June 14, 2007; doi:10.1038/sj.leu.2404805

Appearance of bone marrow lymphocytosis predicts an optimal response to imatinib therapy in patients with chronic myeloid leukemia FREE

S Mustjoki, T Lundán, S Knuutila and K Porkka

Leukemia 21: 2363-2368; advance online publication, June 14, 2007; doi:10.1038/sj.leu.2404807

PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma FREE

J Abubaker, P P Bavi, S Al-Harbi, A K Siraj, F Al-Dayel, S Uddin and K Al-Kuraya

Leukemia 21: 2368-2370; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404873

Hypermethylation of TTC12 gene in acute lymphoblastic leukemia FREE

R Wattanawaraporn, T Singhsilarak, I Nuchprayoon and A Mutirangura

Leukemia 21: 2370-2373; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404876

Portal venous thrombosis in a young patient with idiopathic myelofibrosis and intrahepatic extramedullary hematopoiesis: a difficult diagnosis, prognosis and management FREE

S Pulini, E D'Amico, R Basilico, M Mereu, F Bacci, A Spadano and G Fioritoni

Leukemia 21: 2373-2375; advance online publication, June 21, 2007; doi:10.1038/sj.leu.2404789

Successful treatment of imatinib-resistant acute megakaryoblastic leukemia with e6a2 BCR/ABL: use of dasatinib and reduced-conditioning stem-cell transplantation FREE

S Corm, A Renneville, E Rad-Quesnel, N Grardel, C Preudhomme and B Quesnel

Leukemia 21: 2376-2377; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404792

Influence of two different regimens of concomitant treatment with asparaginase and dexamethasone on hemostasis in childhood acute lymphoblastic leukemia FREE

I M Appel, C van Kessel-Bakvis, R Stigter and R Pieters

Leukemia 21: 2377-2380; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404793

Campath in haemolytic anaemia and chronic lymphatic leukaemia: an unsuccessful case FREE

P R J Ames, D Aw and M G Rainey

Leukemia 21: 2380-2381; advance online publication, June 14, 2007; doi:10.1038/sj.leu.2404794

Segmental uniparental disomy as a recurrent mechanism for homozygous CEBPA mutations in acute myeloid leukemia FREE

B J Wouters, M A Sanders, S Lugthart, W M C Geertsma-Kleinekoort, E van Drunen, H B Beverloo, B Löwenberg, P J M Valk and R Delwel

Leukemia 21: 2382-2384; advance online publication, June 7, 2007; doi:10.1038/sj.leu.2404795

Lenalidomide as induction therapy before allogeneic stem cell transplantation in a patient with proliferative CMML-2 and del(5q) not involving the EGR1 locus FREE

U Platzbecker, B Mohr, M von Bonin, M Binder, J Schetelig, G Ehninger and M Bornhäuser

Leukemia 21: 2384-2385; advance online publication, June 21, 2007; doi:10.1038/sj.leu.2404811

JAK2-V617F activating mutation in acute myeloid leukemia: prognostic impact and association with other molecular markers FREE

C Vicente, I Vázquez, N Marcotegui, A Conchillo, C Carranza, G Rivell, E Bandrés, I Cristobal, I Lahortiga, M J Calasanz and M D Odero

Leukemia 21: 2386-2390; advance online publication, June 21, 2007; doi:10.1038/sj.leu.2404812

Gene structure, expression profiling and mutation analysis of the tumour suppressor SHIP1 in Caucasian acute myeloid leukaemia FREE

D C Gilby, A C Goodeve, P R Winship, P J Valk, R Delwel and J T Reilly

Leukemia 21: 2390-2393; advance online publication, July 26, 2007; doi:10.1038/sj.leu.2404864

Extramedullary BCR-ABL1-negative myeloid leukemia in a patient with chronic myeloid leukemia and synchronous cytogenetic abnormalities in Philadelphia-positive and -negative clones during imatinib therapy FREE

A Quintás-Cardama, H Kantarjian, L V Abruzzo and J Cortes

Leukemia 21: 2394-2396; advance online publication, August 9, 2007; doi:10.1038/sj.leu.2404865



Impairment of Na+,K+-ATPase in CD95(APO-1)-induced human T-cell leukemia cell apoptosis mediated by glutathione depletion and generation of hydrogen peroxide FREE

W Yin, W Cheng, W Shen, L Shu, J Zhao, J Zhang and Z-C Hua

Leukemia 21: 2397; doi:10.1038/sj.leu.2404890