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International uniform response criteria for multiple myeloma

Leukemia volume 20, pages 1467–1473 (2006)Cite this article

A Corrigendum to this article was published on 25 April 2007

A Corrigendum to this article was published on 22 November 2006

Abstract

New uniform response criteria are required to adequately assess clinical outcomes in myeloma. The European Group for Blood and Bone Marrow Transplant/International Bone Marrow Transplant Registry criteria have been expanded, clarified and updated to provide a new comprehensive evaluation system. Categories for stringent complete response and very good partial response are added. The serum free light-chain assay is included to allow evaluation of patients with oligo-secretory disease. Inconsistencies in prior criteria are clarified making confirmation of response and disease progression easier to perform. Emphasis is placed upon time to event and duration of response as critical end points. The requirements necessary to use overall survival duration as the ultimate end point are discussed. It is anticipated that the International Response Criteria for multiple myeloma will be widely used in future clinical trials of myeloma.

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Author notes

  1. B G M Durie, J-L Harousseau, J S Miguel, J Bladé, B Barlogie, K Anderson, M Gertz, M Dimopoulos, J Westin, P Sonneveld, H Ludwig, G Gahrton, M Beksac, J Crowley, A Belch, M Boccadaro, I Turesson, D Joshua, D Vesole, R Kyle, R Alexanian, G Tricot, M Attal, G Merlini, R Powles, P Richardson, K Shimizu, P Tosi, G Morgan and S V Rajkumar: For members of the International Myeloma Working Group, see Appendix A.

Authors and Affiliations

  1. Aptium Oncology, Inc., Cedars-Sinai Outpatient Cancer Center, Los Angeles, CA, USA

    B G M Durie

  2. Institute de Biologie, Nantes, France

    J-L Harousseau

  3. University of Salamanca, Salamanca, Spain

    J S Miguel

  4. Hospital Clinica, Barcelona, Spain

    J Bladé

  5. MIRT UAMS, Little Rock, Arkansas, USA

    B Barlogie & G Tricot

  6. DFCI, Boston, MA, USA

    K Anderson

  7. Mayo Clinic, Rochester, MN, USA

    M Gertz, R Kyle & S V Rajkumar

  8. Alexandra Hospital, Athens, Greece

    M Dimopoulos

  9. University of Lund, Sweden

    J Westin

  10. Rotterdam, The Netherlands

    P Sonneveld

  11. Wilhelminenspital Der Stat Wien, Vienna, Austria

    H Ludwig

  12. Karolinska Institutet, Stockholm, Sweden

    G Gahrton

  13. Ankara University, Turkey

    M Beksac

  14. Cancer Research and Biostatistics, Seattle, WA, USA

    J Crowley

  15. Cross Cancer Institute, Canada

    A Belch

  16. University of Torino, Torino, Italy

    M Boccadaro

  17. University of Malmo, Malmo, Sweden

    I Turesson

  18. Royal Prince Alfred Hospital, Sydney, Australia

    D Joshua

  19. St Vincent's Comprehensive Cancer Center, New York, NY, USA

    D Vesole

  20. MD Anderson, Houston, TX, USA

    R Alexanian

  21. Purpan Hospital, Toulouse, France

    M Attal

  22. University of Pavia, Pavia, Italy

    G Merlini

  23. The Leukemia and Myeloma Program, Wimbledon, UK

    R Powles

  24. Dana Farber Cancer Institute, Boston, MA, USA

    P Richardson

  25. Nagoya City Midori General Hospital, Nagoya, Japan

    K Shimizu

  26. University of Bologna, Bologna, Italy

    P Tosi

  27. Royal Marsden Hospital, London, UK

    G Morgan

Authors
  1. B G M Durie
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  2. J-L Harousseau
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  3. J S Miguel
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  4. J Bladé
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  5. B Barlogie
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  6. K Anderson
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  7. M Gertz
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  8. M Dimopoulos
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  9. J Westin
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  10. P Sonneveld
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  11. H Ludwig
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  12. G Gahrton
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  13. M Beksac
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  14. J Crowley
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  15. A Belch
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  16. M Boccadaro
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  17. I Turesson
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  18. D Joshua
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  19. D Vesole
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  20. R Kyle
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  21. R Alexanian
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  22. G Tricot
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  23. M Attal
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  26. P Richardson
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  27. K Shimizu
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  28. P Tosi
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  29. G Morgan
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  30. S V Rajkumar
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Consortia

on behalf of the International Myeloma Working Group

Corresponding authors

Correspondence to B G M Durie or S V Rajkumar.

Additional information

Please see Corrigendum. The PDF and HTML versions of this article remain uncorrected.

Please click on the abstract or full text for the link to the corrigendum attached to this article. Please note the article and PDF have not been corrected.

Appendix A.

Appendix A.

International myeloma working group:

Raymond Alexanian, MD Anderson, Houston, Texas

Kenneth Anderson, DFCI, Boston, Massachusetts

Michael Attal, Purpan Hospital, Toulouse, France

Herve Avet-Loiseau, Institute de Biologie, Nantes, France

Leif Bergsagel, Mayo Clinic Scottsdale

Joan Bladé, Hospital Clinica, Barcelona, Spain

Bart Barlogie, MIRT UAMS Little Rock, Arkanas

Regis Batille, Nantes, France

Meral Beksac, Ankara University, Turkey

Andrew Belch, Cross Cancer Institute, Canada

Mario Boccadoro, University of Torino

Michele Cavo, Bologna, Italy

Tony Child, United Kingdom

Ray Comenzo, Memorial-Sloan Kettering Cancer Center, New York

John Crowley, Cancer Research and Biostatistics, Seattle, Washington

William Dalton, H Lee Moffitt, Tampa, Florida

Faith Davies, Royal Marsden Hospital, London, England

Meletios Dimopoulos, Alexandra Hospital, Athens, Greece

Angela Dispenzieri, Mayo Clinic, Rochester, Minnesota

Brian Durie, Cedars-Sinai Outpatient Medical Center, Los Angeles, California

Theirry Facon, Centre Hospitalier Regional Universitaire de Lille, France

Dorotea Fantl, Buenos Aires, Argentina

Jean-Paul Fermand, Paris, France

Rafael Fonseca, Mayo Clinic Scottsdale, Scottsdale, Arizona

Gosta Gahrton, Karolinska Institutet, Stockholm , Sweden

Morie Gertz, Mayo Clinic

Hartmut Goldschmidt, Heidelberg, Germany

Philip Greipp, Mayo Clinic

Roman Hajek, Brno University, Brno, Czech Republic

Jean-Luc Harousseau, Institute de Biologie, Nantes, France

Kim Hawkins, Statistician, United Kingdom

Martin Hjorth, Data manager, Netherlands

Vania Hungria, Clinica San Germano, Sao Paolo, Brazil

Mohamad Hussein, The Cleveland Clinic, Cleveland, Ohio, USA

Peter Jacobs, South Africa

Mariana Juni, Fundaleu, Buenos Aires, Argentina

Douglas Joshua, Royal Prince Alfred Hospital, Sydney, Australia

Michael Katz, New York

Michio Kawano, Yamaguchi University, Ube, Japan

Shaji Kumar, Mayo Clinic

Robert Kyle, Mayo Clinic

Juan Lahuerta, Madrid, Spain

Henk Lokhorst, University Hospital, Utrecht, The Netherlands

Heinz Ludwig, Wilhelminenspital Der Stat Wien, Vienna

Jayesh Mehta, Northwestern University, Chicago

Giampaolo Merlini, University of Pavia, Pavia, Italy

Philippe Moreau, Nantes, France

Gareth Morgan, Royal Marsden Hospital, London

Antonio Palumbo, Cathedra Ematologia, Torino, Italy

Santiago Pavlovsky, Fundaleu, Buenos Aires, Argentina

Amara Nouel, Bolivar, Venezuela

Susie Novis, IMF, Los Angeles, California

Raymond Powles, Leukaemia & Myeloma, Wimbledon

Linda Pilarski, The University of Alberta, Edmonton Alberta, Canada

S Vincent Rajkumar, Mayo Clinic

Tony Reiman, Cross Cancer Institute, Canada

Paul Richardson, Dana Farber Cancer Institute, Boston, Massachusetts

Angelina Rodriquez Morales, Bonco MetroPolitano de Sangre, Caracas, Venezuela

Kazuyuki Shimizu, Nagoya City Midori General Hospital, Nagoya, Japan

David Siegel, Hackensack, Cancer Center, Hackensack, New Jersey

Guido Tricot, MIRT UAMS, Little Rock, Arkansas

Jesus San Miguel, University of Salamanca

Seema Singhal, Northwestern University

Pieter Sonneveld, Erasmus University Hospital, Rotterdam, The Netherlands

Keith Stewart, Mayo Clinic Scottsdale

Patrizia Tosi, Bologna, Italy

Ingemar Turesson, Malmo, Sweden

Ivan Van Riet, Brussels Vrija University

David Vesole, St Vincent's Comprehensive Cancer Center, New York

Donna Weber, MD Anderson, Houston, Texas

Jan Westin, University of Gothenberg, Sweden

Keith Wheatley, University of Birmingham, Edgbaston, Birmingham, UK

Brian Van Ness, University of Minnesota

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Durie, B., Harousseau, JL., Miguel, J. et al. International uniform response criteria for multiple myeloma. Leukemia 20, 1467–1473 (2006). https://doi.org/10.1038/sj.leu.2404284

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