TABLE OF CONTENTS

Volume 20, Issue 9 (September 2006)

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Leading Article

International uniform response criteria for multiple myeloma

Please click on the abstract or full text for the link to the corrigendum attached to this article. Please note the article and PDF have not been corrected.

B G M Durie, J-L Harousseau, J S Miguel, J Bladé, B Barlogie, K Anderson, M Gertz, M Dimopoulos, J Westin, P Sonneveld, H Ludwig, G Gahrton, M Beksac, J Crowley, A Belch, M Boccadaro, I Turesson, D Joshua, D Vesole, R Kyle, R Alexanian, G Tricot, M Attal, G Merlini, R Powles, P Richardson, K Shimizu, P Tosi, G Morgan and S V Rajkumar on behalf of the International Myeloma Working Group

Leukemia 20: 1467-1473; advance online publication, July 20, 2006; doi:10.1038/sj.leu.2404284

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Editorials

The fever of stem cells has taken possession of us! FREE

M Z Ratajczak and N M-B Killmann

Leukemia 20: 1474; doi:10.1038/sj.leu.2404311

Myeloproliferative disorders: premalignant, stem cell, G1 diseases?

H Lelièvre, A Ferrand, M-J Mozziconacci, D Birnbaum and B Delaval

Leukemia 20: 1475-1480; advance online publication, June 29, 2006; doi:10.1038/sj.leu.2404295

Treatment of myelodysplastic syndromes with exogenous erythropoietin: a new therapeutic paradigm

S D Mundle and A Raza

Leukemia 20: 1481-1483; doi:10.1038/sj.leu.2404291

The role of cytogenetics in myeloma

F Zhan, J Sawyer and G Tricot

Leukemia 20: 1484-1486; doi:10.1038/sj.leu.2404330

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Spotlight Review

Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication FREE

J Ratajczak, M Wysoczynski, F Hayek, A Janowska-Wieczorek and M Z Ratajczak

Leukemia 20: 1487-1495; advance online publication, July 20, 2006; doi:10.1038/sj.leu.2404296

Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast

C Graux, J Cools, L Michaux, P Vandenberghe and A Hagemeijer

Leukemia 20: 1496-1510; advance online publication, July 6, 2006; doi:10.1038/sj.leu.2404302

Ubiquitylation in normal and malignant hematopoiesis: novel therapeutic targets

J A F Marteijn, J H Jansen and B A van der Reijden

Leukemia 20: 1511-1518; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404319

Hyperforin, a new lead compound against the progression of cancer and leukemia?

C Quiney, C Billard, C Salanoubat, J D Fourneron and J P Kolb

Leukemia 20: 1519-1525; advance online publication, June 22, 2006; doi:10.1038/sj.leu.2404301

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Original Articles

Therapy

Imatinib and methylprednisolone alternated with chemotherapy improve the outcome of elderly patients with Philadelphia-positive acute lymphoblastic leukemia: results of the GRAALL AFR09 study

A Delannoy, E Delabesse, V Lhéritier, S Castaigne, F Rigal-Huguet, E Raffoux, F Garban, O Legrand, S Bologna, V Dubruille, P Turlure, O Reman, M Delain, F Isnard, D Coso, P Raby, A Buzyn, S Caillères, S Darre, C Fohrer, A Sonet, C Bilhou-Nabera, M-C Béné, H Dombret, P Berthaud and X Thomas for the Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL)

Leukemia 20: 1526-1532; advance online publication, July 13, 2006; doi:10.1038/sj.leu.2404320

Long-term follow-up of patients with peripheral T-cell lymphomas treated up-front with high-dose chemotherapy followed by autologous stem cell transplantation

P Corradini, C Tarella, F Zallio, A Dodero, M Zanni, P Valagussa, A M Gianni, A Rambaldi, T Barbui and S Cortelazzo

Leukemia 20: 1533-1538; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404306

Acute Leukemias

Perforin polymorphism A91V and susceptibility to B-precursor childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

P A Mehta, S M Davies, A Kumar, M Devidas, S Lee, T Zamzow, J Elliott, J Villanueva, J Pullen, Y Zewge and A Filipovich

Leukemia 20: 1539-1541; advance online publication, June 22, 2006; doi:10.1038/sj.leu.2404299

Chronic Myeloproliferative Disorders

Gene expression signatures associated with the resistance to imatinib

Y-J Chung, T-M Kim, D-W Kim, H Namkoong, H K Kim, S-A Ha, S Kim, S M Shin, J-H Kim, Y-J Lee, H-M Kang and J W Kim

Leukemia 20: 1542-1550; advance online publication, July 20, 2006; doi:10.1038/sj.leu.2404310

Stem Cells

Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells

H Kimura, E Morii, J-i Ikeda, S Ezoe, J-X Xu, N Nakamichi, Y Tomita, H Shibayama, Y Kanakura and K Aozasa

Leukemia 20: 1551-1556; advance online publication, July 13, 2006; doi:10.1038/sj.leu.2404312

A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy

I Yakoub-Agha, P Saule, S Depil, J-B Micol, C Grutzmacher, F Boulanger-Villard, F Bauters, J-P Jouet, J-P Dessaint and M Labalette

Leukemia 20: 1557-1565; advance online publication, July 6, 2006; doi:10.1038/sj.leu.2404308

Cytogenetics and Molecular Genetics

Establishment of a new human acute monocytic leukemia cell line TZ-1 with t(1;11)(p32;q23) and fusion gene MLL-EPS15

M Sagawa, T Shimizu, T Shimizu, N Awaya, T Mitsuhashi, Y Ikeda, S Okamoto and M Kizaki

Leukemia 20: 1566-1571; advance online publication, July 6, 2006; doi:10.1038/sj.leu.2404305

Oncogenes Fusion Genes and Tumor Supressor Genes

Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias

S Malempati, D Tibbitts, M Cunningham, Y Akkari, S Olson, G Fan and R C Sears

Leukemia 20: 1572-1581; advance online publication, July 20, 2006; doi:10.1038/sj.leu.2404317

Animal Models

MN1-TEL, the product of the t(12;22) in human myeloid leukemia, immortalizes murine myeloid cells and causes myeloid malignancy in mice

C Carella, J Bonten, J Rehg and G C Grosveld

Leukemia 20: 1582-1592; advance online publication, June 29, 2006; doi:10.1038/sj.leu.2404298

Lymphoma

Evidence for an oncogenic role of AHI-1 in Sezary syndrome, a leukemic variant of human cutaneous T-cell lymphomas

A Ringrose, Y Zhou, E Pang, L Zhou, A E-J Lin, G Sheng, X-J Li, A Weng, M W Su, M R Pittelkow and X Jiang

Leukemia 20: 1593-1601; advance online publication, July 13, 2006; doi:10.1038/sj.leu.2404321

Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma

Y Han, H M Amin, C Frantz, B Franko, J Lee, Q Lin and R Lai

Leukemia 20: 1602-1609; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404323

Myeloma

Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma

L Chiecchio, R K M Protheroe, A H Ibrahim, K L Cheung, C Rudduck, G P Dagrada, E D Cabanas, T Parker, M Nightingale, A Wechalekar, K H Orchard, C J Harrison, N C P Cross, G J Morgan and F M Ross on behalf of the UK Myeloma Forum

Leukemia 20: 1610-1617; advance online publication, July 6, 2006; doi:10.1038/sj.leu.2404304

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Letters to the Editor

Megakaryocyte colony-forming unit growth is enhanced by alemtuzumab: in vitro experiments and a case report of acquired amegakaryocytic thrombocytopenic purpura

M Doubek, Z Kor caronístek, D Havranová, L S caronmardová and J Mayer

Leukemia 20: 1618-1619; advance online publication, July 20, 2006; doi:10.1038/sj.leu.2404337

Suppressor of cytokine signaling-3 is overexpressed in erythroid precursors of myelodysplastic syndrome

A F Baker, W Bellamy, W R Tate, W B Bair III, R Heaton and A F List

Leukemia 20: 1620-1621; advance online publication, July 20, 2006; doi:10.1038/sj.leu.2404322

The JAK2V617F mutation is detectable at very low level in peripheral blood of healthy donors

P Sidon, H El Housni, B Dessars and P Heimann

Leukemia 20: 1622; advance online publication, June 15, 2006; doi:10.1038/sj.leu.2404292

TPM3/PDGFRB fusion transcript and its reciprocal in chronic eosinophilic leukemia

R Rosati, R La Starza, L Luciano, P Gorello, C Matteucci, V Pierini, S Romoli, B Crescenzi, B Rotoli, M F Martelli, F Pane and C Mecucci

Leukemia 20: 1623-1624; advance online publication, July 13, 2006; doi:10.1038/sj.leu.2404307

REL-positive double minute chromosomes in follicular lymphoma

J C Reader, X F Zhao, M S Butler, A P Rapoport and Y Ning

Leukemia 20: 1624-1626; advance online publication, June 15, 2006; doi:10.1038/sj.leu.2404289

Unusual immunophenotypic shift in a patient with T-cell acute lymphoblastic leukemia

V H J van der Velden, K van Lom, P G Hoogeveen, H B Beverloo and D A Breems

Leukemia 20: 1626-1629; advance online publication, June 22, 2006; doi:10.1038/sj.leu.2404297

Imatinib mesylate does not impair the immunogenicity of human myeloid blood dendritic cells

R Wehner, M Wendisch, K Schäkel, M Bornhäuser, U Platzbecker, B Mohr, A Temme, M Bachmann, E P Rieber and M Schmitz

Leukemia 20: 1629-1632; advance online publication, July 13, 2006; doi:10.1038/sj.leu.2404315

Non-classical antileukemia activity of early recovering NK cells after induction chemotherapy and HLA-identical stem cell transplantation in myeloid leukemias

G Sconocchia, D del Principe and A J Barrett

Leukemia 20: 1632-1633; advance online publication, June 29, 2006; doi:10.1038/sj.leu.2404300

Cord blood donor cell leukemia in recipients

M F Greaves

Leukemia 20: 1633-1634; advance online publication, June 22, 2006; doi:10.1038/sj.leu.2404293

Trisomy 4, a new chromosomal abnormality in Waldenström's macroglobulinemia: a study of 39 cases

C Terré, F Nguyen-Khac, C Barin, M J Mozziconacci, V Eclache, C Léonard, E Chapiro, H Farhat, A Bouyon, P Rousselot, S Choquet, M Spentchian, P Dubreuil, V Leblond and S Castaigne

Leukemia 20: 1634-1636; advance online publication, July 13, 2006; doi:10.1038/sj.leu.2404314

A novel somatic K-Ras mutation in juvenile myelomonocytic leukemia

C Reimann, M Arola, M Bierings, A Karow, M M van den Heuvel-Eibrink, H Hasle, C M Niemeyer and C P Kratz

Leukemia 20: 1637-1638; advance online publication, July 6, 2006; doi:10.1038/sj.leu.2404303

A novel translocation t(3;21)(p21;q22) in acute myelogenous leukemia preceding a late-appearing Philadelphia chromosome

A Quintás-Cardama, L V Abruzzo, F J Giles, J Jorgensen, J Cortes, J E Sarriera, H Kantarjian and S Verstovsek

Leukemia 20: 1638-1640; advance online publication, June 22, 2006; doi:10.1038/sj.leu.2404283

Refractory anemia with ringed sideroblasts associated with marked thrombocytosis harbors JAK2 mutation and shows overlapping myeloproliferative and myelodysplastic features

S A Wang, R P Hasserjian, J M Loew, E V Sechman, D Jones, S Hao, Q Liu, W Zhao, M Mehdi, N Galili, B Woda and A Raza

Leukemia 20: 1641-1644; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404316

Nucleophosmin status may influence the therapeutic decision in de novo acute myeloid leukemia with normal karyotype

V Bardet, L D Costa, C Elie, S Malinge, C Demur, J Tamburini, P C Lefebvre, F Witz, B Lioure, E Jourdan, A Pigneux, N Ifrah, M Attal, F Dreyfus, P Mayeux, C Lacombe, A Bennaceur-Griscelli, O A Bernard, D Bouscary and C Récher for the GOELAMS: Groupe Ouest Est d'étude des Leucémies et des Autres Maladies du Sang

Leukemia 20: 1644-1646; advance online publication, June 22, 2006; doi:10.1038/sj.leu.2404294

Inhibition of bortezomib-induced apoptosis by red blood cell uptake

L M C Wheat, S L Kohlhaas, J Monbaliu, R De Coster, A Majid, R J Walewska and M J S Dyer

Leukemia 20: 1646-1649; advance online publication, June 22, 2006; doi:10.1038/sj.leu.2404290

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Obituary

Obituary

D Ribatti

Leukemia 20: 1650; doi:10.1038/sj.leu.2404309

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Corrigendum

Immediate early gene X-1 (IEX-1) is differentially induced by retinoic acids in NB4 and KG1 cells: possible implication in the distinct phenotype of retinoic acid-responsive and -resistant leukemic cells FREE

A Arlt, J Minkenberg, B Kocs, M Gros zligmann, M-L Kruse, U R Fölsch and H Schäfer

Leukemia 20: 1651; doi:10.1038/sj.leu.2404347

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