Inflammation and multiple myeloma: the Toll connection

A Mantovani and C Garlanda

Leukemia 20: 937-938; doi:10.1038/sj.leu.2404229

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Acute Leukemias

The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells

K Matkovic, F Brugnoli, V Bertagnolo, H Banfic and D Visnjic

Leukemia 20: 941-951; advance online publication, April 13, 2006; doi:10.1038/sj.leu.2404204

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Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome

G J Roboz, F J Giles, A F List, J E Cortes, R Carlin, M Kowalski, S Bilic, E Masson, M Rosamilia, M W Schuster, D Laurent and E J Feldman

Leukemia 20: 952-957; advance online publication, April 13, 2006; doi:10.1038/sj.leu.2404213

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Genomic gain at 6p21: a new cryptic molecular rearrangement in secondary myelodysplastic syndrome and acute myeloid leukemia

R La Starza, A Aventin, C Matteucci, B Crescenzi, S Romoli, N Testoni, V Pierini, S Ciolli, C Sambani, A Locasciulli, E Di Bona, M Lafage-Pochitaloff, M F Martelli, P Marynen and C Mecucci

Leukemia 20: 958-964; advance online publication, April 13, 2006; doi:10.1038/sj.leu.2404208

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Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML)

N Boissel, H Leroy, B Brethon, N Philippe, S de Botton, A Auvrignon, E Raffoux, T Leblanc, X Thomas, O Hermine, B Quesnel, A Baruchel, G Leverger, H Dombret and C Preudhomme for the Acute Leukemia French Association (ALFA) and the Leucémies Aiguës Myéloblastiques de l'Enfant (LAME) Cooperative Groups

Leukemia 20: 965-970; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404188

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JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained

D P Steensma, R F McClure, J E Karp, A Tefferi, T L Lasho, H L Powell, G W DeWald and S H Kaufmann

Leukemia 20: 971-978; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404206

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Activation of FGFR1 signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells

M A Karajannis, L Vincent, R DiRenzo, S V Shmelkov, F Zhang, E J Feldman, P Bohlen, Z Zhu, H Sun, P Kussie and S Rafii

Leukemia 20: 979-986; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404203

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Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis

Y Lu, Y-B Xu, T-T Yuan, M-G Song, M Lübbert, M Fliegauf and G-Q Chen

Leukemia 20: 987-993; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404218

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Molecular profiling reveals myeloid leukemia cell lines to be faithful model systems characterized by distinct genomic aberrations

F G Rücker, S Sander, K Döhner, H Döhner, J R Pollack and L Bullinger

Leukemia 20: 994-1001; doi:10.1038/sj.leu.2404235

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Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome

G Xu, R Kanezaki, T Toki, S Watanabe, Y Takahashi, K Terui, I Kitabayashi and E Ito

Leukemia 20: 1002-1008; advance online publication, April 20, 2006; doi:10.1038/sj.leu.2404223

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Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis

L Xia, E Wurmbach, S Waxman and Y Jing

Leukemia 20: 1009-1016; advance online publication, March 30, 2006; doi:10.1038/sj.leu.2404198

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Myelodyspasias

Inhibition of p38 MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X_L, Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo

T A Navas, A N Nguyen, T Hideshima, M Reddy, J Y Ma, E Haghnazari, M Henson, E G Stebbins, I Kerr, G O'Young, A M Kapoun, S Chakravarty, B Mavunkel, J Perumattam, G Luedtke, S Dugar, S Medicherla, A A Protter, G F Schreiner, K C Anderson and L S Higgins

Leukemia 20: 1017-1027; advance online publication, April 13, 2006; doi:10.1038/sj.leu.2404200

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Chronic Myeloproliferative Disorders

Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis

C Zheng, L Li, M Haak, B Brors, O Frank, M Giehl, A Fabarius, M Schatz, A Weisser, C Lorentz, N Gretz, R Hehlmann, A Hochhaus and W Seifarth

Leukemia 20: 1028-1034; advance online publication, April 13, 2006; doi:10.1038/sj.leu.2404227

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BCR-ABL activity and its response to drugs can be determined in CD34⁺ CML stem cells by CrkL phosphorylation status using flow cytometry

A Hamilton, L Elrick, S Myssina, M Copland, H Jørgensen, J V Melo and T Holyoake

Leukemia 20: 1035-1039; advance online publication, March 30, 2006; doi:10.1038/sj.leu.2404189

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Molecular persistence of chronic myeloid leukemia caused by donor T cells specific for lineage-restricted maturation antigens not recognizing immature progenitor-cells

P A von dem Borne, S A P van Luxemburg-Heijs, M H M Heemskerk, I Jedema, A Mulder, R Willemze and J H F Falkenburg

Leukemia 20: 1040-1046; advance online publication, March 9, 2006; doi:10.1038/sj.leu.2404169

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Identification of genes involved in imatinib resistance in CML: a gene-expression profiling approach

R Villuendas, J L Steegmann, M Pollán, L Tracey, A Granda, E Fernández-Ruiz, L F Casado, J Martínez, P Martínez, L Lombardía, L Villalón, J Odriozola and M A Piris

Leukemia 20: 1047-1054; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404197

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A quantitative assay for JAK2 ^V617F mutation in myeloproliferative disorders by ARMS-PCR and capillary electrophoresis

A M Vannucchi, A Pancrazzi, C Bogani, E Antonioli and P Guglielmelli

Leukemia 20: 1055-1060; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404209

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Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi()-LMC GROUP)

F E Nicolini, S Corm, Q-H Lê, N Sorel, S Hayette, D Bories, T Leguay, L Roy, S Giraudier, M Tulliez, T Facon, F-X Mahon, J-M Cayuela, P Rousselot, M Michallet, C Preudhomme, F Guilhot and C Roche-Lestienne

Leukemia 20: 1061-1066; advance online publication, April 27, 2006; doi:10.1038/sj.leu.2404236

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A novel MHC-associated Proteinase 3 peptide isolated from primary chronic myeloid leukaemia cells further supports the significance of this antigen for the immunotherapy of myeloid leukaemias

A J Knights, A O Weinzierl, T Flad, B-a Guinn, L Mueller, G J Mufti, S Stevanovic and G Pawelec

Leukemia 20: 1067-1072; advance online publication, April 20, 2006; doi:10.1038/sj.leu.2404234

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Chronic Lymphocytic Leukemia

The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro

A J Steele, D T Jones, K Ganeshaguru, V M Duke, B C Yogashangary, J M North, M W Lowdell, P D Kottaridis, A B Mehta, A G Prentice, A V Hoffbrand and R G Wickremasinghe

Leukemia 20: 1073-1079; advance online publication, April 20, 2006; doi:10.1038/sj.leu.2404230

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Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression

M Bilban, D Heintel, T Scharl, T Woelfel, M M Auer, E Porpaczy, B Kainz, A Kröber, V J Carey, M Shehata, C Zielinski, W Pickl, S Stilgenbauer, A Gaiger, O Wagner, U Jäger and and the German CLL Study Group

Leukemia 20: 1080-1088; advance online publication, April 13, 2006; doi:10.1038/sj.leu.2404220

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Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation

L Reiniger, C Bödör, Á Bognár, Z Balogh, J Csomor, Á Szepesi, L Kopper and A Matolcsy

Leukemia 20: 1089-1095; advance online publication, March 16, 2006; doi:10.1038/sj.leu.2404183

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Redirection of CMV-specific CTL towards B-CLL via CD20-targeted HLA/CMV complexes

R Mous, P Savage, E B M Remmerswaal, R A W van Lier, E Eldering and M H J van Oers

Leukemia 20: 1096-1102; advance online publication, March 23, 2006; doi:10.1038/sj.leu.2404185

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Minimal Residual Disease

Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations

P Gorello, G Cazzaniga, F Alberti, M G Dell'Oro, E Gottardi, G Specchia, G Roti, R Rosati, M F Martelli, D Diverio, F Lo Coco, A Biondi, G Saglio, C Mecucci and B Falini

Leukemia 20: 1103-1108; advance online publication, March 16, 2006; doi:10.1038/sj.leu.2404149

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Differentiation

Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells

H Peng, Z-W Du and J-W Zhang

Leukemia 20: 1109-1116; advance online publication, April 20, 2006; doi:10.1038/sj.leu.2404212

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Stem Cells

Comparison between anagrelide and hydroxycarbamide in their activities against haematopoietic progenitor cell growth and differentiation: selectivity of anagrelide for the megakaryocytic lineage

Y Hong, G Wang, A Gutierrez del Arroyo, J Hernandez, C Skene and J D Erusalimsky

Leukemia 20: 1117-1122; advance online publication, March 23, 2006; doi:10.1038/sj.leu.2404180

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Lymphoma

Paucity of FOXP3⁺ cells in skin and peripheral blood distinguishes Sézary syndrome from other cutaneous T-cell lymphomas

C-D Klemke, B Fritzsching, B Franz, E V Kleinmann, N Oberle, N Poenitz, J Sykora, A H Banham, G Roncador, A Kuhn, S Goerdt, P H Krammer and E Suri-Payer

Leukemia 20: 1123-1129; advance online publication, March 23, 2006; doi:10.1038/sj.leu.2404182

Abstract | Full Text | PDF | Supplementary information

Myeloma

Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors

G Jego, R Bataille, A Geffroy-Luseau, G Descamps and C Pellat-Deceunynck

Leukemia 20: 1130-1137; advance online publication, April 20, 2006; doi:10.1038/sj.leu.2404226

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Toll-like receptors mediate proliferation and survival of multiple myeloma cells

J Bohnhorst, T Rasmussen, S H Moen, M Fløttum, L Knudsen, M Børset, T Espevik and A Sundan

Leukemia 20: 1138-1144; advance online publication, April 13, 2006; doi:10.1038/sj.leu.2404225

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HCV-NS3 and IgG-Fc crossreactive IgM in patients with type II mixed cryoglobulinemia and B-cell clonal proliferations

V De Re, D Sansonno, M P Simula, L Caggiari, D Gasparotto, M Fabris, F A Tucci, V Racanelli, R Talamini, M Campagnolo, S Geremia, F Dammacco and S De Vita

Leukemia 20: 1145-1154; advance online publication, April 13, 2006; doi:10.1038/sj.leu.2404201

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Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome

C-Y Chen, L-I Lin, J-L Tang, W Tsay, H-H Chang, Y-C Yeh, C-F Huang, R-J Chiou, M Yao, B-S Ko, Y-C Chen, K-H Lin, D-T Lin and H-F Tien

Leukemia 20: 1155-1158; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404190

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Inactivation of p53 and deletion of ATM in B-CLL patients in relation to IgVH mutation status and previous treatment

M Trbusek, J Malcikova, J Smardova, V Kuhrova, D Mentzlova, H Francova, S Bukovska, M Svitakova, P Kuglik, V Linkova, M Doubek, Y Brychtova, J Zacal, J Kujickova, S Pospisilova, D Dvorakova, J Vorlicek and J Mayer

Leukemia 20: 1159-1161; advance online publication, March 30, 2006; doi:10.1038/sj.leu.2404195

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Twenty-seven cases of drug-induced interstitial lung disease associated with imatinib mesylate

K Ohnishi, F Sakai, S Kudoh and R Ohno

Leukemia 20: 1162-1164; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404207

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The lack of association between JAK2 V617F mutation and myelodysplastic syndrome with or without myelofibrosis

S-F Yip, C-C So, Ay-Y Chan, Hs-Y Liu, Ts-K Wan and L-C Chan

Leukemia 20: 1165; advance online publication, March 30, 2006; doi:10.1038/sj.leu.2404196

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The fibroblast growth factors in multiple myeloma

P Krejci, P B Mekikian and W R Wilcox

Leukemia 20: 1165-1168; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404202

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Mutations of N-RAS, FLT3 and p53 genes are not involved in the development of acute leukemia transformed from myeloproliferative diseases with JAK2 mutation

M Suzuki, A Abe, H Kiyoi, M Murata, Y Ito, K Shimada, Y Morishita, T Kinoshita and T Naoe

Leukemia 20: 1168-1169; advance online publication, March 23, 2006; doi:10.1038/sj.leu.2404186

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Reliability of quantitative chimerism results: assessment of sample performance using novel parameters

D Kristt and T Klein

Leukemia 20: 1169-1172; advance online publication, April 20, 2006; doi:10.1038/sj.leu.2404191

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Epigenetic disruption of two proapoptotic genes MAPK10/JNK3 and PTPN13/FAP-1 in multiple lymphomas and carcinomas through hypermethylation of a common bidirectional promoter

J Ying, H Li, Y Cui, A H Y Wong, C Langford and Q Tao

Leukemia 20: 1173-1175; advance online publication, March 30, 2006; doi:10.1038/sj.leu.2404193

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t(5;12)(q23–31;p13) with ETV6-ACSL6 gene fusion in polycythemia vera

A Murati, J Adélaïde, V Gelsi-Boyer, A Etienne, V Rémy, H Fezoui, D Sainty, L Xerri, N Vey, S Olschwang, D Birnbaum, M Chaffanet and M J Mozziconacci

Leukemia 20: 1175-1178; advance online publication, March 30, 2006; doi:10.1038/sj.leu.2404194

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Autoimmune hemolytic anemias and IgG antierythrocyte autoantibodies in Waldenström's macroglobulinemia: association with FcRIIa polymorphism

S Poulain, I Dervite, X Leleu, J Fernandes, L Stalnikiewicz, A-S Moreau, V Coiteux, S de Botton, P Duthilleul and P Morel

Leukemia 20: 1179-1181; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404199

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Essential thrombocythemias without V617F JAK2 mutation are clonal hematopoietic stem cell disorders

J-J Kiladjian, N Elkassar, B Cassinat, G Hetet, S Giraudier, N Balitrand, C Conejero, J Briere, P Fenaux, C Chomienne and B Grandchamp

Leukemia 20: 1181-1183; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404214

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HOXA cluster deregulation in T-ALL associated with both a TCRD-HOXA and a CALM-AF10 chromosomal translocation

J Bergeron, E Clappier, B Cauwelier, N Dastugue, C Millien, E Delabesse, K Beldjord, F Speleman, J Soulier, E Macintyre and V Asnafi

Leukemia 20: 1184-1187; advance online publication, March 30, 2006; doi:10.1038/sj.leu.2404187

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Identification of truncated RUNX1 and RUNX1-PRDM16 fusion transcripts in a case of t(1;21)(p36;q22)-positive therapy-related AML

M-J P L Stevens-Kroef, E F P M Schoenmakers, M van Kraaij, E Huys, S Vermeulen, B van der Reijden and A Geurts van Kessel

Leukemia 20: 1187-1189; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404210

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Aberrant gene promoter methylation marking disease progression in multiple myeloma

C-S Chim, R Liang, M-H Leung, S-F Yip and Y-L Kwong

Leukemia 20: 1190-1192; advance online publication, April 6, 2006; doi:10.1038/sj.leu.2404205

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