TABLE OF CONTENTS
Volume 20, Issue 12 (December 2006)
Spotlight Keynote Address
Transfusions after nonmyeloablative or reduced-intensity conditioning regimens FREE
F Baron, G Vanstraelen and Y Beguin
Leukemia 20: 2081-2086; advance online publication, October 12, 2006; doi:10.1038/sj.leu.2404431
Original Articles
Therapy
Intestinal mucosal dysfunction and infection during remission-induction therapy for acute myeloid leukaemia
E J Bow and J B Meddings
Leukemia 20: 2087-2092; advance online publication, November 2, 2006; doi:10.1038/sj.leu.2404440
Acute Leukemias
Cytotoxic activity of gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukemia correlates with the expression of protein kinase Syk
L Balaian and E D Ball
Leukemia 20: 2093-2101; advance online publication, October 19, 2006; doi:10.1038/sj.leu.2404437
Chronic Lymphoblastic Leukemia
Flow cytometric protein expression profiling as a systematic approach for developing disease-specific assays: identification of a chronic lymphocytic leukaemia-specific assay for use in rituximab-containing regimens
A C Rawstron, R de Tute, A S Jack and P Hillmen
Leukemia 20: 2102-2110; advance online publication, October 19, 2006; doi:10.1038/sj.leu.2404416
Signal Transduction and Cytokines
Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors FREE
J Gits, D van Leeuwen, H P Carroll, I P Touw and A C Ward
Leukemia 20: 2111-2118; advance online publication, October 26, 2006; doi:10.1038/sj.leu.2404448
Sensitivity and Resistance to Therapy
Resistance of infant leukemia with MLL rearrangement to tumor necrosis factor-related apoptosis-inducing ligand: a possible mechanism for poor sensitivity to antitumor immunity
T Inukai, X Zhang, M Goto, K Hirose, K Uno, K Akahane, A Nemoto, K Goi, H Sato, K Takahashi, H Honna, K Kagami, K Nakamoto, H Yagita, K Okumura, T Koyama-Okazaki, S Nakazawa and K Sugita
Leukemia 20: 2119-2129; advance online publication, October 26, 2006; doi:10.1038/sj.leu.2404429
DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412
C H Seedhouse, H M Hunter, B Lloyd-Lewis, A-M Massip, M Pallis, G I Carter, M Grundy, S Shang and N H Russell
Leukemia 20: 2130-2136; advance online publication, October 26, 2006; doi:10.1038/sj.leu.2404439
Oncogenes Fusion Genes and Tumor Suppressor Genes
Proteomic discovery of Max as a novel interacting partner of C/EBP
: a Myc/Max/Mad link FREE
A A Zada, J A Pulikkan, D Bararia, M Geletu, A K Trivedi, M Y Balkhi, W D Hiddemann, D G Tenen, H M Behre and G Behre
Leukemia 20: 2137-2146; advance online publication, November 2, 2006; doi:10.1038/sj.leu.2404438
Stem Cells
Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells
H Gal, N Amariglio, L Trakhtenbrot, J Jacob-Hirsh, O Margalit, A Avigdor, A Nagler, S Tavor, L Ein-Dor, T Lapidot, E Domany, G Rechavi and D Givol
Leukemia 20: 2147-2154; advance online publication, October 12, 2006; doi:10.1038/sj.leu.2404401
Allogeneic stem cell transplantation improves the outcome of adults with t(1;19)/E2A-PBX1 and t(4;11)/MLL-AF4 positive B-cell acute lymphoblastic leukemia: results of the prospective multicenter LALA-94 study
N Vey, X Thomas, C Picard, T Kovascovicz, C Charin, J M Cayuela, H Dombret, N Dastugue, F Huguet, C Bastard, A Stamatoulas, M Giollant, O Tournilhac, E Macintyre, A Buzyn, D Bories, M Kuentz, F Dreyfus, A Delannoy, S Raynaud, N Gratecos, D Bordessoule, S de Botton, C Preudhomme, O Reman, X Troussard, A Pigneux, C Bilhou, J P Vernant, C Boucheix and J Gabert For The GET-LALA Group the Swiss Group for Clinical Cancer Research (SAKK)
Leukemia 20: 2155-2161; advance online publication, October 12, 2006; doi:10.1038/sj.leu.2404420
Lymphoma
The CCR4 as a novel-specific molecular target for immunotherapy in Hodgkin lymphoma
T Ishida, T Ishii, A Inagaki, H Yano, S Kusumoto, M Ri, H Komatsu, S Iida, H Inagaki and R Ueda
Leukemia 20: 2162-2168; advance online publication, October 12, 2006; doi:10.1038/sj.leu.2404415
Letters to the Editor
Glutathione S-transferase (GSTM1, GSTT1 and GSTA1) polymorphisms and outcomes after treatment for acute myeloid leukemia: pharmacogenetics in Southwest Oncology Group (SWOG) clinical trials
J R Weiss, K J Kopecky, J Godwin, J Anderson, C L Willman, K B Moysich, M L Slovak, A Hoque and C B Ambrosone
Leukemia 20: 2169-2171; advance online publication, September 28, 2006; doi:10.1038/sj.leu.2404421
PASD1, a DLBCL-associated cancer testis antigen and candidate for lymphoma immunotherapy
C D O Cooper, A P Liggins, K Ait-Tahar, G Roncador, A H Banham and K Pulford
Leukemia 20: 2172-2174; advance online publication, October 5, 2006; doi:10.1038/sj.leu.2404424
CMRL-T, a novel T-cell line showing asynchronous phenotype (CD34+/CD1a-/TCR
+) and dual T-cell receptor chain
R Di Noto, P Mirabelli, E Mariotti, L Sacchetti, F Pane, B Rotoli, C Lo Pardo, L Del Vecchio, C Mecucci and F Salvatore
Leukemia 20: 2175-2177; advance online publication, October 26, 2006; doi:10.1038/sj.leu.2404452
Perforin A91V polymorphism and putative susceptibility to hematological malignancies
S Muralitharan, Y Wali and A V Pathare
Leukemia 20: 2178; advance online publication, October 12, 2006; doi:10.1038/sj.leu.2404433
Prospective multicentric molecular study for poor prognosis fusion transcripts at diagnosis in adult B-lineage ALL patients: the LALA 94 experience
C Picard, S Hayette, C Bilhou-Nabera, J M Cayuela, E Delabesse, N Frenoy, C Preudhomme, M Dupont, C Bastard, D Bories, J L Vaerman, F Davi, N Dastugue, S Raynaud, M Lafage, F Deschaseaux, T Fest, M P Gaub, V Lhéritier, X Thomas, C Charrin, C Boucheix, H Dombret, E MacIntyre, D Fière and J Gabert
Leukemia 20: 2178-2181; advance online publication, October 12, 2006; doi:10.1038/sj.leu.2404408
Antibody-mediated targeting of viral vectors to the Fc receptor expressed on acute myeloid leukemia cells
T Würdinger, M H Verheije, L M van der Aa, B J Bosch, C A M de Haan, V W van Beusechem, W R Gerritsen and P J M Rottier
Leukemia 20: 2182-2184; advance online publication, October 12, 2006; doi:10.1038/sj.leu.2404422
Hornerin gene was involved in a case of acute myeloid leukemia transformed from myelodysplastic syndrome with t(1;2)(q21;q37)
L Wang, Y-Y Wang, Q Cao, Z Chen and S-J Chen
Leukemia 20: 2184-2187; advance online publication, October 19, 2006; doi:10.1038/sj.leu.2404436
Association with the single-nucleotide polymorphism (Glu785Lys) of the granulocyte colony-stimulating factor receptor with myelodysplastic syndromes and acute myeloid leukemia with multlineage dysplasia
U Platzbecker, U Germing, U Schäkel, T Illmer, S Soucek, M Schaich, G Ehninger and C Thiede
Leukemia 20: 2188-2189; advance online publication, October 5, 2006; doi:10.1038/sj.leu.2404399
t(3;12)(q26;q14) in polycythemia vera is associated with upregulation of the HMGA2 gene
C T Storlazzi, F Albano, C Locunsolo, A Lonoce, S Funes, M C Guastadisegni, L Cimarosto, L Impera, P D'Addabbo, I Panagopoulos, G Specchia and M Rocchi
Leukemia 20: 2190-2192; advance online publication, October 5, 2006; doi:10.1038/sj.leu.2404418
Do RARA/PML fusion gene deletions confer resistance to ATRA-based therapy in patients with acute promyelocytic leukemia?
S Subramaniyam, S V Nandula, G Nichols, M Weiner, P Satwani, B Alobeid, G Bhagat and V V Murty
Leukemia 20: 2193-2195; advance online publication, September 28, 2006; doi:10.1038/sj.leu.2404406
Report on two novel nucleotide exchanges in the JAK2 pseudokinase domain: D620E and E627E
S Schnittger, U Bacher, W Kern, M Schröder, T Haferlach and C Schoch
Leukemia 20: 2195-2197; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404325
Eradication of JAK2 V617F mutation after allogeneic transplantation in a patient with myelofibrosis with myeloid metaplasia
A Fiorini, G Reddiconto, G Farina, S Marietti, M Palladino, P Chiusolo, G Leone and S Sica
Leukemia 20: 2198-2199; advance online publication, October 12, 2006; doi:10.1038/sj.leu.2404430
The downregulation of asparagine synthetase expression can increase the sensitivity of cells resistant to L-asparaginase
B S Li, L J Gu, C Y Luo, W S Li, L M Jiang, S H Shen, H Jiang, S H Shen, B Zhang, J Chen, H L Xue and J Y Tang
Leukemia 20: 2199-2201; advance online publication, October 12, 2006; doi:10.1038/sj.leu.2404423
Transition from EML1-ABL1 to NUP214-ABL1 positivity in a patient with acute T-lymphoblastic leukemia
K De Keersmaecker, I Lahortiga, C Graux, P Marynen, J Maertens, J Cools and P Vandenberghe
Leukemia 20: 2202-2204; advance online publication, October 5, 2006; doi:10.1038/sj.leu.2404425
Alemtuzumab as first-line therapy for B-cell chronic lymphocytic leukemia: long-term follow-up of clinical effects, infectious complications and risk of Richter transformation
C Karlsson, S Norin, E Kimby, B Sander, A Porwit MacDonald, B Nilsson, E Johansson, H Mellstedt, J Lundin and A Österborg
Leukemia 20: 2204-2207; advance online publication, October 19, 2006; doi:10.1038/sj.leu.2404435
The PU.1 transcription factor induces cyclin D2 expression in U937 cells
L Vicari, A Eramo, L Manzella, L Malaguarnera, G Iannolo, M Gulisano, R De Maria, A Messina and P Vigneri
Leukemia 20: 2208-2210; advance online publication, October 19, 2006; doi:10.1038/sj.leu.2404447
Detection of a new JAK2 D620E mutation in addition to V617F in a patient with polycythemia vera
F Grünebach, U Bross-Bach, L Kanz and P Brossart
Leukemia 20: 2210-2211; advance online publication, September 28, 2006; doi:10.1038/sj.leu.2404419
Clonal T- and natural killer-cell large granular lymphocyte proliferations in a single patient established by array-based comparative genomic hybridization analysis
Y Sandberg, V O Dezentjé, K Szuhai, A J van Houte, D Tielemans, I L M Wolvers-Tettero, J J M van Dongen, R van der Griend and A W Langerak
Leukemia 20: 2212-2214; advance online publication, October 26, 2006; doi:10.1038/sj.leu.2404451
Stability of cord blood RNA measured by house keeping transcripts: relevance for large-scale studies of childhood leukaemia
M Olsen, H O Madsen, H Hjalgrim, A Ford and K Schmiegelow
Leukemia 20: 2214-2217; advance online publication, October 19, 2006; doi:10.1038/sj.leu.2404446
Two new cases of acute promyelocytic leukemia following mitoxantrone treatment in patients with multiple sclerosis
A Ledda, G Caocci, G Spinicci, E Cocco, E Mamusa and La Nasa G
Leukemia 20: 2217-2218; advance online publication, October 19, 2006; doi:10.1038/sj.leu.2404443
Corrigenda
Flt-3 internal tandem duplication hampers differentiation of AML blasts towards leukemic dendritic cells FREE
I Houtenbos, T M Westers, G J Ossenkoppele, A A van de Loosdrecht, C J Hess and Q Waisfisz
Leukemia 20: 2219; doi:10.1038/sj.leu.2404427
International uniform response criteria for multiple myeloma FREE
B G M Durie, J-L Harousseau, J S Miguel, J Bladé, B Barlogie, K Anderson, M Gertz, M Dimopoulos, J Westin, P Sonneveld, H Ludwig, G Gahrton, M Beksac, J Crowley, A Belch, M Boccadaro, I Turesson, D Joshua, D Vesole, R Kyle, R Alexanian, G Tricot, M Attal, G Merlini, R Powles, P Richardson, K Shimizu, P Tosi and G Morgan SV Rajkumar on behalf of the International Myeloma Working Group
Leukemia 20: 2220; doi:10.1038/sj.leu.2404428
