TABLE OF CONTENTS
Volume 20, Issue 11 (November 2006)
Spotlight Review
The pleiotropic effects of the SDF-1–CXCR4 axis in organogenesis, regeneration and tumorigenesis FREE
M Z Ratajczak, E Zuba-Surma, M Kucia, R Reca, W Wojakowski and J Ratajczak
Leukemia 20: 1915-1924; advance online publication, August 10, 2006; doi:10.1038/sj.leu.2404357
Reviews
Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia
S Branford, N C P Cross, A Hochhaus, J Radich, G Saglio, J Kaeda, J Goldman and T Hughes
Leukemia 20: 1925-1930; advance online publication, September 14, 2006; doi:10.1038/sj.leu.2404388
The role of microRNAs in normal hematopoiesis and hematopoietic malignancies
J Kluiver, B-J Kroesen, S Poppema and A van den Berg
Leukemia 20: 1931-1936; advance online publication, September 14, 2006; doi:10.1038/sj.leu.2404387
Megakaryocytic dysfunction in myelodysplastic syndromes and idiopathic thrombocytopenic purpura is in part due to different forms of cell death
E J Houwerzijl, N R Blom, J J L van der Want, E Vellenga and J T M de Wolf
Leukemia 20: 1937-1942; advance online publication, September 7, 2006; doi:10.1038/sj.leu.2404385
Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia FREE
J Pedersen-Bjergaard, D H Christiansen, F Desta and M K Andersen
Leukemia 20: 1943-1949; advance online publication, September 21, 2006; doi:10.1038/sj.leu.2404381
Original Articles
Molecular Targets for Therapy
Correlation of neuropilin-1 overexpression to survival in acute myeloid leukemia
M Kreuter, K Woelke, R Bieker, C Schliemann, M Steins, T Buechner, W E Berdel and R M Mesters
Leukemia 20: 1950-1954; advance online publication, August 31, 2006; doi:10.1038/sj.leu.2404384
Therapy
High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia
T V Ch Skärby, H Anderson, J Heldrup, J A Kanerva, H Seidel and K Schmiegelow on behalf of the Nordic Society of Paediatric Haematology and Oncology (NOPHO)
Leukemia 20: 1955-1962; advance online publication, September 21, 2006; doi:10.1038/sj.leu.2404404
Acute Leukemias
Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias
T Palomero, K McKenna, J O-Neil, I Galinsky, R Stone, K Suzukawa, E Stiakaki, M Kalmanti, E A Fox, M A Caligiuri, J C Aster, A T Look and A A Ferrando
Leukemia 20: 1963-1966; advance online publication, September 28, 2006; doi:10.1038/sj.leu.2404409
Identification of Notch target genes in uncommitted T-cell progenitors: no direct induction of a T-cell specific gene program FREE
F Weerkamp, T C Luis, B A E Naber, E E L Koster, L Jeannotte, J J M van Dongen and F J T Staal
Leukemia 20: 1967-1977; advance online publication, September 21, 2006; doi:10.1038/sj.leu.2404396
Identification of a molecular signature for leukemic promyelocytes and their normal counterparts: focus on DNA repair genes
I Casorelli, E Tenedini, E Tagliafico, M F Blasi, A Giuliani, M Crescenzi, E Pelosi, U Testa, C Peschle, L Mele, D Diverio, M Breccia, F Lo-Coco, S Ferrari and M Bignami
Leukemia 20: 1978-1988; advance online publication, September 21, 2006; doi:10.1038/sj.leu.2404376
Chronic Myeloproliferative Disorders
Heterogeneity in detecting Abl kinase mutations and better sensitivity using circulating plasma RNA
W Ma, H Kantarjian, I Jilani, M Gorre, K Bhalla, O Ottmann, F Giles and M Albitar
Leukemia 20: 1989-1991; advance online publication, August 24, 2006; doi:10.1038/sj.leu.2404355
Signal Transduction and Cytokines
Alloreaction increases or restores CD40, CD54, and/or HLA molecule expression in acute myelogenous leukemia blasts, through secretion of inflammatory cytokines: dominant role for TNF
, in concert with IFN
A Eljaafari, J Van Snick, A Voisin, F Cormont, A Farre, J Bienvenu, J Bernaud, D Rigal and X Thomas
Leukemia 20: 1992-2001; advance online publication, September 14, 2006; doi:10.1038/sj.leu.2404375
Cytogenetics and Molecular Genetics
Identification of cryptic aberrations and characterization of translocation breakpoints using array CGH in high hyperdiploid childhood acute lymphoblastic leukemia
K Paulsson, M Heidenblad, H Mörse, Å Borg, T Fioretos and B Johansson
Leukemia 20: 2002-2007; advance online publication, September 14, 2006; doi:10.1038/sj.leu.2404372
Oncogenes Fusion Genes and Tumor Suppressor Genes
FLT3 K663Q is a novel AML-associated oncogenic kinase: determination of biochemical properties and sensitivity to Sunitinib (SU11248)
M M Schittenhelm, K W H Yee, J W Tyner, L McGreevey, A D Haley, A Town, D J Griffith, T Bainbridge, R M Braziel, A-M O'Farrell, J M Cherrington and M C Heinrich
Leukemia 20: 2008-2014; advance online publication, September 14, 2006; doi:10.1038/sj.leu.2404374
Immunology
T cells stimulated by CD40L positive leukemic blasts-pulsed dendritic cells meet optimal functional requirements for adoptive T-cell therapy
G D'Amico, M Bonamino, E Dander, V Marin, G Basso, A Balduzzi, E Biagi and A Biondi
Leukemia 20: 2015-2024; advance online publication, September 21, 2006; doi:10.1038/sj.leu.2404390
Improved human T-cell responses against synthetic HLA-0201 analog peptides derived from the WT1 oncoprotein
J Pinilla-Ibarz, R J May, T Korontsvit, M Gomez, B Kappel, V Zakhaleva, R H Zhang and D A Scheinberg
Leukemia 20: 2025-2033; advance online publication, August 31, 2006; doi:10.1038/sj.leu.2404380
Myeloma
Prognostic value of chromosome 1q21 gain by fluorescent in situ hybridization and increase CKS1B expression in myeloma
R Fonseca, S A Van Wier, W J Chng, R Ketterling, M Q Lacy, A Dispenzieri, P L Bergsagel, S V Rajkumar, P R Greipp, M R Litzow, T Price-Troska, K J Henderson, G J Ahmann and M A Gertz
Leukemia 20: 2034-2040; advance online publication, October 5, 2006; doi:10.1038/sj.leu.2404403
Letters to the Editor
Quantification of marrow CD34+ cells: an important tool for distinguishing between hypoplastic myelodysplastic syndromes and aplastic anemia
A Orazi
Leukemia 20: 2041; advance online publication, September 14, 2006; doi:10.1038/sj.leu.2404393
Reply to 'Quantification of marrow CD34+ cells: an important tool for distinguishing between hypoplastic myelodysplastic syndromes and aplastic anemia' by A Orazi
W H Matsui, R A Brodsky, B D Smith, M J Borowitz and R J Jones
Leukemia 20: 2041-2042; advance online publication, September 14, 2006; doi:10.1038/sj.leu.2404394
Reply to Matsui et al.
A Orazi
Leukemia 20: 2042; advance online publication, September 14, 2006; doi:10.1038/sj.leu.2404395
Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes
S Sobue, T Iwasaki, C Sugisaki, K Nagata, R Kikuchi, M Murakami, A Takagi, T Kojima, Y Banno, Y Akao, Y Nozawa, R Kannagi, M Suzuki, A Abe, T Naoe and T Murate
Leukemia 20: 2042-2046; advance online publication, September 7, 2006; doi:10.1038/sj.leu.2404386
A dual-color FISH assay distinguishes between ELL and MLLT1 (ENL) gene rearrangements in t(11;19)-positive acute leukemia
J S Biggerstaff, W Liu, M L Slovak, D Bobadilla, E Bryant, C Glotzbach and L G Shaffer
Leukemia 20: 2046-2050; advance online publication, September 14, 2006; doi:10.1038/sj.leu.2404371
Philadelphia chromosome unmasked as a secondary genetic change in acute myeloid leukemia on imatinib treatment
S F Yip, T S K Wan, H S Y Liu, M L G Wong, C-C So and L C Chan
Leukemia 20: 2050-2051; advance online publication, October 5, 2006; doi:10.1038/sj.leu.2404407
Wilms' tumor 1 mutation accumulated during therapy in acute myeloid leukemia: biological and clinical implications
C G Nyvold, J Stentoft, K Brændstrup, D Melsvik, S K Moestrup, C Juhl-Christensen, H Hasle and P Hokland
Leukemia 20: 2051-2054; advance online publication, September 21, 2006; doi:10.1038/sj.leu.2404389
Human neutrophil elastase is not a target for therapy in chronic myeloid leukaemia
E K Allan, T L Holyoake and H G Jørgensen
Leukemia 20: 2054-2055; advance online publication, September 28, 2006; doi:10.1038/sj.leu.2404411
Infusion of bcr/abl peptide-reactive donor T cells to achieve molecular remission of chronic myeloid leukemia after CD34+ selected allogeneic hematopoietic cell transplantation
M Bornhauser, C Thiede, J Babatz, J Schetelig, T Illmer, A Kiani, U Platzbecker, W Herr, E-P Rieber, G Ehninger and M Schmitz
Leukemia 20: 2055-2057; advance online publication, August 31, 2006; doi:10.1038/sj.leu.2404383
A novel Bcr-Abl splice isoform is associated with the L248V mutation in CML patients with acquired resistance to imatinib
F X Gruber, H Hjorth-Hansen, I Mikkola, L Stenke and T Johansen
Leukemia 20: 2057-2060; advance online publication, September 28, 2006; doi:10.1038/sj.leu.2404400
The JAK2 V617F mutation is rare in RARS but common in RARS-T
M M Ceesay, N C Lea, W Ingram, N B Westwood, J Gäken, A Mohamedali, J Cervera, U Germing, N Gattermann, A Giagounidis, Z Garcia-Casado, G Sanz and G J Mufti
Leukemia 20: 2060-2061; advance online publication, August 24, 2006; doi:10.1038/sj.leu.2404373
The familial risk of Hodgkin's lymphoma ranks among the highest in the Swedish Family-Cancer Database
A Altieri and K Hemminki
Leukemia 20: 2062-2063; advance online publication, August 31, 2006; doi:10.1038/sj.leu.2404378
Hematologic and cytogenetic response to lenalidomide monotherapy in acute myeloid leukemia arising from JAK2V617F positive, del(5)(q13q33) myelodysplastic syndrome
R A Mesa, A Tefferi, C-Yang Li and D P Steensma
Leukemia 20: 2063-2064; advance online publication, September 21, 2006; doi:10.1038/sj.leu.2404398
Elevated levels of serum CD44 and E-cadherin predict an unfavourable outcome in myelodysplastic syndromes
J Loeffler-Ragg, M Steurer, H Ulmer, S Skvortsov, B Kircher, M Herold, H Zwierzina and R Stauder
Leukemia 20: 2064-2067; advance online publication, September 7, 2006; doi:10.1038/sj.leu.2404382
JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less?
S Verstovsek, R T Silver, N C P Cross and A Tefferi
Leukemia 20: 2067; advance online publication, August 31, 2006; doi:10.1038/sj.leu.2404379
High occurrence of JAK2 V617 mutation in refractory anemia with ringed sideroblasts associated with marked thrombocytosis
A Renneville, B Quesnel, A Charpentier, L Terriou, A Crinquette, J-L Laï, C Cossement, P Lionne-Huyghe, C Rose, F Bauters and C Preudhomme
Leukemia 20: 2067-2070; advance online publication, September 21, 2006; doi:10.1038/sj.leu.2404405
Novel Ig V gene features of t(14;18) and t(3;14) de novo diffuse large B-cell lymphoma displaying germinal center-B cell like and non-germinal center-B cell like markers
F Jardin, S S Sahota, P Ruminy, F Parmentier, J M Picquenot, V Rainville, G Buchonnet, S Lepretre, H Tilly and C Bastard
Leukemia 20: 2070-2074; advance online publication, September 14, 2006; doi:10.1038/sj.leu.2404370
The size of duplication does not add to the prognostic significance of FLT3 internal tandem duplication in acute myeloid leukemia patients
V Ponziani, G Gianfaldoni, F Mannelli, F Leoni, S Ciolli, P Guglielmelli, E Antonioli, G Longo, A Bosi and A M Vannucchi
Leukemia 20: 2074-2076; advance online publication, August 31, 2006; doi:10.1038/sj.leu.2404368
High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis
K Steiner, M Graf, K Hecht, S Reif, L Rossbacher, K Pfister, H-J Kolb, H M Schmetzer and G Multhoff
Leukemia 20: 2076-2079; advance online publication, September 21, 2006; doi:10.1038/sj.leu.2404391
