TABLE OF CONTENTS
Volume 20, Issue 10 (October 2006)
Editorial |
Spotlights |
Review |
Concise Review |
Original Articles |
Letters to the Editor
Spotlight Editorial
Reduced-intensity conditioning allogeneic stem cell transplantation: hype, reality or time for a rethink? FREE
M Mohty, A Nagler and N M-B Killmann
Leukemia 20: 1653-1654; doi:10.1038/sj.leu.2404336
Editorial
Difference between hematological malignancy and Solid tumor research articles published in four major medical journals
A Chizuka, M Suda, T Shibata, E Kusumi, A Hori, T Hamaki, Y Kodama, K Horigome, Y Kishi, K Kobayashi, T Matsumura, K Yuji, Y Tanaka and M Kami
Leukemia 20: 1655-1657; doi:10.1038/sj.leu.2404369
Towards defining the lymphoma methylome
J I Martín-Subero, E Ballestar, M Esteller and R Siebert
Leukemia 20: 1658-1660; doi:10.1038/sj.leu.2404344
Spotlights
Stem cell transplantation with reduced-intensity conditioning regimens: a review of ten years experience with new transplant concepts and new therapeutic agents FREE
A J Barrett and B N Savani
Leukemia 20: 1661-1672; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404334
Reduced-intensity conditioning for acute myeloid leukemia: is this strategy correct FREE
H M Lazarus and J M Rowe
Leukemia 20: 1673-1682; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404328
The current status of reduced-intensity allogeneic hematopoietic stem cell transplantation for multiple myeloma FREE
W I Bensinger
Leukemia 20: 1683-1689; advance online publication, August 3, 2006; doi:10.1038/sj.leu.2404333
Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning FREE
F Baron and B M Sandmaier
Leukemia 20: 1690-1700; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404335
Optimization of allogeneic transplant conditioning: not the time for dogma FREE
H J Deeg, M B Maris, B L Scott and E H Warren
Leukemia 20: 1701-1705; advance online publication, August 3, 2006; doi:10.1038/sj.leu.2404327
Review
Telomere length dynamics in normal hematopoiesis and in disease states characterized by increased stem cell turnover
T H Brümmendorf and S Balabanov
Leukemia 20: 1706-1716; advance online publication, August 3, 2006; doi:10.1038/sj.leu.2404339
Concise Review
Loss of antibodies and response to (re-)vaccination in children after treatment for acute lymphocytic leukemia: a systematic review
C M van Tilburg, E A M Sanders, M M Rovers, T F W Wolfs and M B Bierings
Leukemia 20: 1717-1722; advance online publication, August 3, 2006; doi:10.1038/sj.leu.2404326
Original Articles
Therapy
Non-infusional vs intravenous consolidation chemotherapy in elderly patients with acute myeloid leukemia: final results of the EORTC-GIMEMA AML-13 randomized phase III trial
U Jehn, S Suciu, X Thomas, F Lefrère, P Muus, Z Berneman, J-P Marie, F Adamo, G Fillet, F Nobile, F Ricciuti, G Leone, V Rizzoli, M Montanaro, F Beeldens, P Fazi, F Mandelli, R Willemze, T de Witte and S Amadori
Leukemia 20: 1723-1730; advance online publication, August 17, 2006; doi:10.1038/sj.leu.2404356
Molecular Targets for Therapy
Altered glucose metabolism in childhood pre-B acute lymphoblastic leukaemia
J M Boag, A H Beesley, M J Firth, J R Freitas, J Ford, K Hoffmann, A J Cummings, N H de Klerk and U R Kees
Leukemia 20: 1731-1737; advance online publication, August 31, 2006; doi:10.1038/sj.leu.2404365
BCR-ABL fusion regions as a source of multiple leukemia-specific CD8+ T-cell epitopes
J H Kessler, S A Bres-Vloemans, P A van Veelen, A de Ru, I J G Huijbers, M Camps, A Mulder, R Offringa, J W Drijfhout, O C Leeksma, F Ossendorp and C J M Melief
Leukemia 20: 1738-1750; advance online publication, August 24, 2006; doi:10.1038/sj.leu.2404354
Identification of a molecular signature predictive of sensitivity to differentiation induction in acute myeloid leukemia
E Tagliafico, E Tenedini, R Manfredini, A Grande, F Ferrari, E Roncaglia, S Bicciato, R Zini, S Salati, E Bianchi, C Gemelli, M Montanari, T Vignudelli, T Zanocco-Marani, S Parenti, P Paolucci, G Martinelli, P P Piccaluga, M Baccarani, G Specchia, U Torelli and S Ferrari
Leukemia 20: 1751-1758; advance online publication, August 17, 2006; doi:10.1038/sj.leu.2404358
Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma
T Krejsgaard, C S Vetter-Kauczok, A Woetmann, P Lovato, T Labuda, K W Eriksen, Q Zhang, J C Becker and N Ødum
Leukemia 20: 1759-1766; advance online publication, August 17, 2006; doi:10.1038/sj.leu.2404350
Chronic Myeloproliferative Disorders
Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate
E Jabbour, H Kantarjian, D Jones, M Talpaz, N Bekele, S O'Brien, X Zhou, R Luthra, G Garcia-Manero, F Giles, M B Rios, S Verstovsek and J Cortes
Leukemia 20: 1767-1773; advance online publication, July 20, 2006; doi:10.1038/sj.leu.2404318
Chronic Lymphocytic Leukemia
Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status
A Hüttmann, L Klein-Hitpass, J Thomale, R Deenen, A Carpinteiro, H Nückel, P Ebeling, A Führer, J Edelmann, L Sellmann, U Dührsen and J Dürig
Leukemia 20: 1774-1782; advance online publication, August 17, 2006; doi:10.1038/sj.leu.2404363
Minimal Residual Disease
The kinetics of reduction of minimal residual disease impacts on duration of response and survival of patients with acute myeloid leukemia
F Buccisano, L Maurillo, V Gattei, G Del Poeta, M I Del Principe, M C Cox, P Panetta, M Irno Consalvo, C Mazzone, B Neri, L Ottaviani, D Fraboni, A Tamburini, F Lo-Coco, S Amadori and A Venditti
Leukemia 20: 1783-1789; advance online publication, July 13, 2006; doi:10.1038/sj.leu.2404313
Cytogenetics and Molecular Genetics
Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2
R R Einerson, M E Law, H E Blair, P J Kurtin, R F McClure, R P Ketterling, H C Flynn, A Dogan and E D Remstein
Leukemia 20: 1790-1799; advance online publication, August 3, 2006; doi:10.1038/sj.leu.2404340
Signal Transduction and Cytokines
Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia
R A Mesa, A Tefferi, T S Lasho, D Loegering, R F McClure, H L Powell, N T Dai, D P Steensma and S H Kaufmann
Leukemia 20: 1800-1808; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404338
Differentiation
Downregulation of topoisomerase II
in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest
K Chikamori, J E Hill, D R Grabowski, E Zarkhin, A G Grozav, S A J Vaziri, J Wang, A V Gudkov, L R Rybicki, R M Bukowski, A Yen, M Tanimoto, M K Ganapathi and R Ganapathi
Leukemia 20: 1809-1818; advance online publication, August 17, 2006; doi:10.1038/sj.leu.2404351
Immunology
Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells
A Loskog, V Giandomenico, C Rossig, M Pule, G Dotti and M K Brenner
Leukemia 20: 1819-1828; advance online publication, August 17, 2006; doi:10.1038/sj.leu.2404366
Animal Models
The Mll-Een knockin fusion gene enhances proliferation of myeloid progenitors derived from mouse embryonic stem cells and causes myeloid leukaemia in chimeric mice
C T Kong, M H Sham, C W E So, K S E Cheah, S J Chen and L C Chan
Leukemia 20: 1829-1839; advance online publication, August 3, 2006; doi:10.1038/sj.leu.2404342
Lymphoma
Prolonged survival and low incidence of late toxic sequelae in advanced follicular lymphoma treated with a TBI-free autografting program: updated results of the multicenter consecutive GITMO trial
M Ladetto, S Vallet, F Benedetti, U Vitolo, M Martelli, V Callea, C Patti, P Coser, A Perrotti, M Sorio, C Boccomini, A Pulsoni, C Stelitano, R Scimè, M Boccadoro, R Rosato, F De Marco, M Zanni, P Corradini and C Tarella
Leukemia 20: 1840-1847; advance online publication, August 24, 2006; doi:10.1038/sj.leu.2404346
Serpin A1 is overexpressed in ALK+ anaplastic large cell lymphoma and its expression correlates with extranodal dissemination
M M Duplantier, L Lamant, F Sabourdy, A de Reynies, G Delsol and E Espinos
Leukemia 20: 1848-1854; advance online publication, August 10, 2006; doi:10.1038/sj.leu.2404352
Differential DNA methylation patterns of small B-cell lymphoma subclasses with different clinical behavior
F B Rahmatpanah, S Carstens, J Guo, O Sjahputera, K H Taylor, D Duff, H Shi, J W Davis, S I Hooshmand, R Chitma-Matsiga and C W Caldwell
Leukemia 20: 1855-1862; advance online publication, August 10, 2006; doi:10.1038/sj.leu.2404345
Myeloma
Thymoglobulin targets multiple plasma cell antigens and has in vitro and in vivo activity in multiple myeloma
M M Timm, T K Kimlinger, J L Haug, M P Kline, P R Greipp, S V Rajkumar and S K Kumar
Leukemia 20: 1863-1869; advance online publication, August 17, 2006; doi:10.1038/sj.leu.2404359
Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients
E De Bruyne, T L Andersen, H De Raeve, E Van Valckenborgh, J Caers, B Van Camp, J-M Delaissé, I Van Riet and K Vanderkerken
Leukemia 20: 1870-1879; advance online publication, August 10, 2006; doi:10.1038/sj.leu.2404343
Letters to the Editor
Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11AXL protein are frequent in primary mediastinal B-cell lymphoma
M A Weniger, K Pulford, S Gesk, S Ehrlich, A H Banham, L Lyne, J I Martin-Subero, R Siebert, M J S Dyer, P Möller and T F E Barth
Leukemia 20: 1880-1882; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404324
The sensitivity of human cells expressing RUNX1-RUNX1T1 to chemotherapeutic agents
A Tonks, L Pearn, K I Mills, A K Burnett and R L Darley
Leukemia 20: 1883-1885; advance online publication, August 17, 2006; doi:10.1038/sj.leu.2404364
Oncogenic kinases of myeloproliferative disorders induce both protein synthesis and G1 activators
H Lelièvre, N Cervera, P Finetti, F Delhommeau, W Vainchenker, F Bertucci and D Birnbaum
Leukemia 20: 1885-1888; advance online publication, August 10, 2006; doi:10.1038/sj.leu.2404361
Characterization of an artificial antigen-presenting cell to propagate cytolytic CD19-specific T cells
T Numbenjapon, L M Serrano, H Singh, C M Kowolik, S Olivares, N Gonzalez, W C Chang, S J Forman, M C Jensen and L J N Cooper
Leukemia 20: 1889-1892; doi:10.1038/sj.leu.2404329
Flt-3 internal tandem duplication hampers differentiation of AML blasts towards leukemic dendritic cells
I Houtenbos, T M Westers, G J Ossenkoppele, A A van de Loosdrecht, C J Hess and Q Waisfisz
Leukemia 20: 1892-1895; advance online publication, August 17, 2006; doi:10.1038/sj.leu.2404348
A microelectronic DNA chip detects the V617F JAK-2 mutation in myeloproliferative disorders
M Di Ianni, L Moretti, B Del Papa, E Gaozza, A S Bell, F Falzetti and A Tabilio
Leukemia 20: 1895-1897; advance online publication, August 10, 2006; doi:10.1038/sj.leu.2404360
Rapid and sensitive typing of NPM1 mutations using LNA-mediated PCR clamping
C Thiede, E Creutzig, T Illmer, M Schaich, V Heise, G Ehninger and O Landt
Leukemia 20: 1897-1899; advance online publication, September 7, 2006; doi:10.1038/sj.leu.2404367
A novel fluorescence-based multiplex PCR assay for rapid simultaneous detection of CEBPA mutations and NPM mutations in patients with acute myeloid leukemias
L-I Lin, T-C Lin, W-C Chou, J-L Tang, D-T Lin and H-F Tien
Leukemia 20: 1899-1903; advance online publication, July 27, 2006; doi:10.1038/sj.leu.2404331
JAK2 V617F mutation analysis in different myeloid lineages (granulocytes, platelets, CFU-MK, BFU-E and CFU-GM) in essential thrombocythemia patients
L Florensa, B Bellosillo, C Besses, E Puigdecanet, B Espinet, E Pérez-Vila, R Longarón, R M Vilà, F Solé and S Serrano
Leukemia 20: 1903-1905; advance online publication, August 3, 2006; doi:10.1038/sj.leu.2404341
High ZAP-70 expression correlates with worse clinical outcome in mantle cell lymphoma
D Hui, L Dabbagh, J Hanson, H M Amin and R Lai
Leukemia 20: 1905-1908; advance online publication, August 17, 2006; doi:10.1038/sj.leu.2404362
Most immature T-ALLs express Ra-IL3 (CD123): possible target for DT-IL3 therapy
L Lhermitte, A de Labarthe, C Dupret, H Lapillonne, C Millien, J Landman-Parker, O Hermine, A Baruchel, F Sigaux, E Macintyre and V Asnafi
Leukemia 20: 1908-1910; advance online publication, August 10, 2006; doi:10.1038/sj.leu.2404349
Promoter DNA methylation of CD10 in lymphoid malignancies
K H Taylor, J Liu, J Guo, J W Davis, H Shi and C W Caldwell
Leukemia 20: 1910-1912; advance online publication, August 10, 2006; doi:10.1038/sj.leu.2404353
