TABLE 1
FROM:
Stem cell transplantation with reduced-intensity conditioning regimens: a review of ten years experience with new transplant concepts and new therapeutic agents
A J Barrett and B N Savani
BACK TO ARTICLETable 1. RIC regimens used in the last decade
| Ref | Conditioning regimen |
Drug dose and schedule ( ATG/antibodies)
| TBI dose | |
|---|---|---|---|---|
| Flu (mg/m2) | Alkylating agent | |||
| 28, 29, 30, 31, 32, 33, 34, 35, 36, 37 | Flu Bu | 120–240 | Bu 3.2–6.6 mg/kg i.v. Bu 8–10 mg p.o. | — |
| 30, 38, 39, 40, 41, 42, 43, 44, 45 | Flu Mel | 90–180 | Mel 70–180 mg/m2 | — |
| 18, 46, 47, 48, 49, 50, 51, 52, 53 | Flu TBI | 90–120 | +Cy 80–120 mg/kg | 2–8 Gy |
| 54, 55, 56 | Cy TBI | — | 80–120 mg/kg | 4–5.5 Gy |
| 40, 57, 58, 59, 60, 61, 62 | Flu Cy | 90–125 | Cy 2–3.6 g/m2 OR Cy 120–200 mg/kg | — |
| 63 | Flu Cy Th | 60 | Cy 60 mg/kg Th 10 mg/kg | — |
| 64 | Thymic radiation+Cy | — | Cy 150–200 mg/kg | |
Ref, reference number; ATG, antithymocyte globulin; TBI, total body irradiation; Flu, Fludarabine; Bu, busulfan, Mel, melphalan, Cy, cyclophosphamide; Th, thiotepa.